Behandlung der Ménièreschen Krankheit. Paukenhöhleninfusion von Lidocain-und Steroidlösung

Sakata, Eiji; Kitago, Yukio; Murata, Yasuhiro; Teramoto, Kazuhiro

doi:10.1016/s0385-8146(86)80002-5

Cited by 30 publications

(12 citation statements)

References 3 publications

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“…In his study of 37 patients, Ristow [21] described that intratympanic lidocaine resulted in 33.3% worse, 39.4% better and 27.3% same hearing performance 2 years after surgery. In a more recent paper, Sakata et al [23] did not confirm any deterioration of hearing after intratympanic instillation of lidocaine. Comparing these data with our own findings (66.7% same, 20.8% better and 12.5% worse hearing), labyrinth anesthesia seems to be a very safe surgical therapy regarding postoperative hearing.…”

Section: Discussionmentioning

confidence: 89%

“…Lempert [16], Kroath [17], Rahm [18], Gejrot [19] and Ristow [20,21] published the positive therapeutical effect of intratympanic lidocaine on vestibular symptoms. In 1985, Fradis et al [22] reported severe to moderate vertigo control in 85.7% of cases, whereas in 1986, Sakata et al [23] observed that 89.4% of patients undergoing labyrinth anesthesia felt at least a noticeable relief of vestibular symptoms. In 1991, Itoh and Sakata [24] reported similar findings after intratympanic instillation of lidocaine.…”

Section: Introductionmentioning

confidence: 99%

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Labyrinth Anesthesia – A Forgotten but Practical Treatment Option in Ménière’s Disease

Adunka

Moustaklis

Weber

et al. 2003

ORL

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The aim of this study was to determine the efficiency of labyrinth anesthesia – the intratympanic instillation of lidocaine – in the treatment of Ménière’s disease and to recall a forgotten method. Twenty-four patients (15 male, 9 female), aged from 19.7 to 80.6 years (mean: 47.8 years) with the clinical diagnosis of unilateral Ménière’s disease who underwent labyrinth anesthesia in our department were included in this retrospective study. After local anesthesia of the tympanic membrane, a solution of 4% lidocaine and furfuryladenine (Kinetin) was instilled into the tympanic cavity. Patient records, a questionnaire and a physical examination were used to evaluate vertigo control, hearing loss, tinnitus, and quality of life according to the AAO-HNS criteria before and after surgery. Postoperatively, 87.5% of patients reported at least a noticeable decrease of vestibular symptoms, 66.7% of these patients were free of attacks for an average of 26.5 months. Postoperative hearing was the same or even improved in 87.5% of our patients. Tinnitus was not affected in any individual. Based on the findings presented herein, we consider labyrinth anesthesia a practicable and, due to its safety, highly recommendable therapeutic option for patients suffering from Ménière’s disease.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Labyrinth Anesthesia – A Forgotten but Practical Treatment Option in Ménière’s Disease

Adunka

Moustaklis

Weber

et al. 2003

ORL

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“…Positive experiences with systemic glucocorticoid treatment of Mé-nière's disease have been reported; however, patients received additional agents, and placebo-controlled clinical trials have not been performed. However, the effectiveness of intratympanically applied glucocorticoids without supplements has been evaluated [188][189][190][191][192][193]. Previous results have indicated effectiveness for vertigo in almost all treated ears and amelioration of tinnitus in most ears but no improvement of hearing [188,189].…”

Section: Ménière's Diseasementioning

confidence: 99%

“…However, the effectiveness of intratympanically applied glucocorticoids without supplements has been evaluated [188][189][190][191][192][193]. Previous results have indicated effectiveness for vertigo in almost all treated ears and amelioration of tinnitus in most ears but no improvement of hearing [188,189]. Preliminary results from recent studies indicate good relief of dizzy spells and preservation of hearing in many patients [190,191].…”

Section: Ménière's Diseasementioning

confidence: 99%

“…In early reports, amelioration of tinnitus was observed after intratympanic glucocorticoid injection in most ears of patients suffering from Ménière's disease [188,189]. In contrast, no effect on tinnitus has recently been established in 20 patients suffering from Ménière's disease who had either received intratympanic application of placebo or dexamethasone on 3 consecutive days [193].…”

Section: Tinnitusmentioning

confidence: 99%

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How Useful Is Corticosteroid Treatment in Cochlear Disorders?

Lamm¹,

Arnold²

1999

Otorhinolaryngol Nova

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The scientific basis for the administration of corticosteroids classified as glucocorticoids in certain cochlear disorders, such as immune-mediated progressive and idiopathic acute sensorineural hearing loss (SNHL), Ménière’s disease and noise-induced hearing loss (NIHL), was discussed. The current knowledge on the physiological functions of endogenous glucocorticoids and the pharmacological effects of their synthetic analogs was summarized. Emphasis was placed on experimental studies on corticosteroids in the cochleovestibular system and on the therapeutic effects of glucocorticoids on SNHL, Ménière’s disease, NIHL and chronic tinnitus obtained from clinical trials. Glucocorticoids exert numerous profound effects on almost every organ system, including mechanisms involved in anti-inflammatory action and immunosuppression. However, inflammatory tissue alterations are not only elicited by bacterial, viral or other immunopathological processes but also by physically and chemically induced cellular damage, tissue ischemia and hypoxia. Regardless of whether one or more of these insults underlie SNHL, Ménière’s disease and NIHL, glucocorticoids effectively counteract subsequent inflammatory tissue damage in the auditory and vestibular system. This was confirmed in experimental studies on immune-mediated progressive SNHL, and thrombosis-induced and noise-induced cochlear ischemia, hypoxia and hearing loss. Glucocorticoid treatment results of immune-mediated progressive and acute idiopathic SNHL are promising, although placebo-controlled trials on the effect in acute idiopathic SNHL have revealed conflicting data (probably due to the small number of patients). Clinical studies on the effect of systemic glucocorticoid monotherapy on Ménière’s disease and NIHL have not yet been performed. After intratympanic application, relief of vertigo, tinnitus and preservation of hearing in Ménière’s disease was observed in previous studies; however, recently none of these effects have been confirmed in a placebo-controlled trial. Similarly, in contrast to previous reports, chronic tinnitus of various origins did not improve after repetitive glucocorticoid application onto the round window membrane using a micropump connected to an implanted microcatheter.

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Lokale Pharmakotherapie des Innenohrs

Lenarz¹

Vestibularfunktion

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Behandlung der Ménièreschen Krankheit. Paukenhöhleninfusion von Lidocain-und Steroidlösung

Cited by 30 publications

References 3 publications

Labyrinth Anesthesia – A Forgotten but Practical Treatment Option in Ménière’s Disease

Labyrinth Anesthesia – A Forgotten but Practical Treatment Option in Ménière’s Disease

How Useful Is Corticosteroid Treatment in Cochlear Disorders?

Lokale Pharmakotherapie des Innenohrs

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