Behandlungsstrategien der malignen Non-Hodgkin-Lymphome im Kindesalter

Gadner, Helmut; Müller-Weihrich, St.; Riehm, H.

doi:10.1159/000215978

Cited by 4 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no involvement of the bone marrow or CSF. The patient was treated with a combination of vincristine, daunorubicin and prednisone followed by asparaginase (BFM-NHL 81/83) (10). No cranial irradiation had been given.…”

Section: Case Reportsmentioning

confidence: 99%

Cerebrospinal fluid exchange after intrathecal methotrexate overdose. A report of two cases

Jakobson¹,

Kreuger²,

Mortimer³

et al. 1992

Acta Paediatrica

View full text Add to dashboard Cite

Two patients aged 11 and four years, were accidentally given a 10-fold overdose of intrathecal methotrexate while being treated for malignant disease. Neither patient developed any signs of neurotoxicity and exchange of lumbar cerebro-spinal fluid was started 3 and 5 h later, respectively. In one of the patients, who received 120 mg of methotrexate intrathecally, 31% of the given dose was recovered during 2 h of cerebrospinal fluid exchange that was started 3 h after the accidental overdosage. No sequelae were observed in any of the patients. Cerebrospinal fluid exchange is safe and can be recommended in all cases of intrathecal methotrexate overdosage. Ventriculo-cisternal perfusion is not necessary in cases of a 10-fold overdose if the patient has no signs of acute neurotoxicity.

show abstract

Section: Case Reportsmentioning

confidence: 99%

Cerebrospinal fluid exchange after intrathecal methotrexate overdose. A report of two cases

Jakobson¹,

Kreuger²,

Mortimer³

et al. 1992

Acta Paediatrica

View full text Add to dashboard Cite

show abstract

Monoclonal antibodies produced by immunization with neoglycoproteins containing galα1‐4galβ1‐4glcβ‐O and galα1‐4galβ1‐4glcnacβ‐O residues: Useful immunochemical and cytochemical reagents for blood group p antigens and a differentiation marker in burkitt lymphoma and other B‐cell malignancies

Brodin

Dahmén²,

Nilsson

et al. 1988

Intl Journal of Cancer

View full text Add to dashboard Cite

Several monoclonal antibodies (MAbs) directed to blood group P1 (Gal alpha 1-4Gal beta 1-4GlcNAc beta-O) and Pk (Gal alpha 1-4Gal beta 1-4Glc beta-O) determinants were produced with high efficiency by using synthetic neoglycoproteins as immunogens. The specificity of IgM and IgG1 MAbs was characterized by binding to defined oligosaccharides and glycoconjugates. Antibodies that bound equally well to P1 and Pk determinants and to Gal alpha 1-4Gal beta 1-O-derivatives were obtained, together with others that showed selective recognition of the entire trisaccharide chain. Selected antibodies were shown to be useful as reagents for detection of the blood group P antigens in glycolipid extracts of erythrocytes and on the surface of erythrocytes of different P phenotypes, demonstrated both by radioimmune assays and hemagglutination. Six IgM MAbs directed to the Pk determinant bound selectively to Burkitt lymphoma cells and 2 of these antibodies (424/3D9 and 424/6A2) could be used as auxiliary reagents in immunofluorescence for diagnosis and classification of B-cell lymphomas and leukemias using flow cytometric analysis. Eight normal individuals and 37 patients with lymphoma or leukemia were studied. Tumor cells of 2/2 patients with "Burkitt-like" lymphoma, 1 patient with centroblastic lymphoma and 2 patients with acute leukemia were strongly stained for the Pk antigen. The staining patterns for differentiation markers classified the tumor cells to a developmental stage closely related to the Burkitt cell type.

show abstract

Non-Hodgkin's Lymphoma

Shad¹,

Magrath²

1997

Pediatric Clinics of North America

View full text Add to dashboard Cite

Behandlungsstrategien der malignen Non-Hodgkin-Lymphome im Kindesalter

Cited by 4 publications

References 2 publications

Cerebrospinal fluid exchange after intrathecal methotrexate overdose. A report of two cases

Cerebrospinal fluid exchange after intrathecal methotrexate overdose. A report of two cases

Non-Hodgkin's Lymphoma

Contact Info

Product

Resources

About