Behavior of a Chitosan–Drug System during Diffusion Processes

Shurshina, A. S.; Galina, A. R.; Kulish, E. I.

doi:10.1134/s0965545x18030100

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…Analysis of the data given in Table 3 unambiguously proves the fact that varying the polymer concentration in the initial solution is an additional factor regulating the rate of drug release. Previously, this kind of impact of the supramolecular organization of the polymer matrix on diffusion processes was discovered in the works [30, 39,40] for the films of physiologically active polymers -chitosan polysaccharides, sodium salt of chitosan succinamide and sodium salt of carboxymethylcellulose.…”

Section: In Vitro Drug Release From Polymer Filmsmentioning

confidence: 99%

Prolonging effect of polyvinyl alcohol on the drug release

et al. 2022

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Polymers are currently of interest as drug delivery systems. The use of polymeric forms of medicinal substances will eliminate or reduce the disadvantages of traditional drugs. The purpose of this work was to assess the ability to prolong the action of polyvinyl alcohol in relation to the drug release when going from dilute to more concentrated solutions. It was established that an increase in the viscosity of the polymer in solution caused by an increase in its concentration results not only in a slowdown in the diffusion of drugs from the polymer solution, but also in a significant decrease in the amount of drugs firmly fixed on the polymer matrix. Since it is the adduct of the polyvinyl alcohol-drug interaction that provides the slow release of the drug from the polymer solution, a decrease in its amount leads to the fact that no enhancement of the prolonging action is observed. It is claimed that when moving from solutions to polymer films, the rate of drug release is also determined by the structure of the polymer matrix. The lower the density of the polymer film, the greater the diffusion coefficient of the drug release from the film. Thus, in the course of evaluating the ability to prolong the action of polyvinyl alcohol, it was shown that using some prolongation techniques, it is possible to achieve targeted regulation of the rate of drug release from polymer dosage forms.

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Section: In Vitro Drug Release From Polymer Filmsmentioning

confidence: 99%