Behavior of aqueous nanocrystalline hydroxyapatite in oral bone regeneration

Zaffe, Davide; Traversa, Giorgio; Mozzati, Marco; Morelli, Fabrizio; D’Angeli, Giovanni

doi:10.5301/jabb.2011.6450

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…As mentioned previously the histological findings of this study revealed a significant increase in percentage of new bone in the Ostim group ( P = 0.015). These findings were similar to the results of various research studies which have confirmed high rates of dense cortical and cancellous bone ingrowth into bony defects with the use of Ostim [ 15 , 16 ].…”

Section: Discussionsupporting

confidence: 91%

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Comparative Study on the Efficacy of Anorganic Bovine Bone (Bio-Oss) and Nanocrystalline Hydroxyapatite (Ostim) in Maxillary Sinus Floor Augmentation

Shirmohammadi

Roshangar

Chitsazi

et al. 2014

International Scholarly Research Notices

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Purpose. The aim of this study was to evaluate the efficacy of anorganic bovine bone (Bio-Oss) in comparison with nanocrystalline hydroxyapatite (Ostim) in sinus floor augmentation. Methods. Ten patients aged 40–80 were selected. All the patients needed sinus floor augmentation due to insufficient bone for simultaneous implant placement. The patients underwent panoramic radiography and cone beam computed tomography (CBCT) prior to surgical procedure. After lifting the sinus membrane, Bio-Oss and Ostim are randomly grafted at one of the two sides. Biopsies were obtained from areas identified 5 months after the surgery and before implant placement and then were prepared for histological analysis. Statistical analysis was performed with nonparametric Wilcoxon signed-rank test for comparison of histological and radiological parameters between the two groups. Results. Histological findings revealed a significant increase in percentages of new bone in the Ostim group (P = 0.015). Furthermore, new bone density was greater with Ostim compared to Bio-Oss (P = 0.038); however, the difference in height increase after surgery did not reach statistical significance (P = 0.191). Conclusion. Despite the limitations of this trial, Ostim and Bio-Oss are useful biomaterials in sinus augmentation and Ostim seems to be even more effective in new bone formation.

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Section: Discussionsupporting

confidence: 91%

“…Due to disadvantages and limitations of allografts and xenografts, more attention has been focused on alloplastic materials. It is known that alloplastic materials act as a scaffold with benefits such as availability, ease of manipulation, fewer complications, and high security [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on the Efficacy of Anorganic Bovine Bone (Bio-Oss) and Nanocrystalline Hydroxyapatite (Ostim) in Maxillary Sinus Floor Augmentation

Shirmohammadi

Roshangar

Chitsazi

et al. 2014

International Scholarly Research Notices

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“…in a remarkably short time. (32) The result of the present study is also consistent with an article published by Araujo et al who demonstrated that the placement of a biomaterial in an extraction socket will enhance bone modeling and compensate the marginal ridge contraction. (33) Another study recommends that the use of nanobone in extractions operations and bone fractures lead to speed healing.…”

Section: Resultssupporting

confidence: 92%

Evaluation of Socket Preservation Using A Synthetic Nanocrystalline Hydroxyapatite

Elkhatib

El-Samad

2020

Al-Azhar Assiut Dental Journal

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Aim: This study was designed to evaluate the socket preservation using a synthetic nanocrystalline hydroxyapatite followed by collagen membrane. Subjects and methods: Fourteen patients were selected from Oral and Maxillofacial clinic of the Faculty of Oral and Dental Medicine, Al-Azhar University, Cairo, Boys. Extraction of tooth of lower premolar area was done to all participants. Then they were divided into 2 groups, where 7 sockets were preserved and the 7 were kept as control. After tooth extraction in the test group nanobone putty form was grafted into the socket. An additional covering was performed by a collagen membrane. A cone beam computed tomography (CBCT) radiograph at 3 and 6 months were done to assess bone density and socket dimensions. All readings were recorded and analyzed statistically. Results: Among the study group, there is a high statistically significant difference between the three measurements (soon after extraction, after 3-and 6-months from operation) as regards the mean of bone density and the three dimensions .Conclusion: Nano hydroxyapatite together with collagen membrane to seal the socket accelerates the formation of bone filling in the extracted bony socket

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“…Ostim ® , a nanoparticular HA aqueous paste, has been described as bone-inducible paste. Several publications observed that Ostim ® particles were not fully resorbed 12 weeks post-surgery 9 11 12 34 . In general all HA pastes used in this study were shown to support bone formation.…”

Section: Discussionmentioning

confidence: 99%

Comparison of nanoparticular hydroxyapatite pastes of different particle content and size in a novel scapula defect model

Hruschka

Tangl

Ryabenkova

et al. 2017

Sci Rep

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Nanocrystalline hydroxyapatite (HA) has good biocompatibility and the potential to support bone formation. It represents a promising alternative to autologous bone grafting, which is considered the current gold standard for the treatment of low weight bearing bone defects. The purpose of this study was to compare three bone substitute pastes of different HA content and particle size with autologous bone and empty defects, at two time points (6 and 12 months) in an ovine scapula drillhole model using micro-CT, histology and histomorphometry evaluation. The nHA-LC (38% HA content) paste supported bone formation with a high defect bridging-rate. Compared to nHA-LC, Ostim® (35% HA content) showed less and smaller particle agglomerates but also a reduced defect bridging-rate due to its fast degradation The highly concentrated nHA-HC paste (48% HA content) formed oversized particle agglomerates which supported the defect bridging but left little space for bone formation in the defect site. Interestingly, the gold standard treatment of the defect site with autologous bone tissue did not improve bone formation or defect bridging compared to the empty control. We concluded that the material resorption and bone formation was highly impacted by the particle-specific agglomeration behaviour in this study.

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Behavior of aqueous nanocrystalline hydroxyapatite in oral bone regeneration

Abstract: The use of Ostim® as bone regenerating material leads to the formation of a highly suitable implant support consisting exclusively of bone in less than 12 months, i.e. in a remarkably short time.

Cited by 4 publications

References 15 publications

Comparative Study on the Efficacy of Anorganic Bovine Bone (Bio-Oss) and Nanocrystalline Hydroxyapatite (Ostim) in Maxillary Sinus Floor Augmentation

Comparative Study on the Efficacy of Anorganic Bovine Bone (Bio-Oss) and Nanocrystalline Hydroxyapatite (Ostim) in Maxillary Sinus Floor Augmentation

Evaluation of Socket Preservation Using A Synthetic Nanocrystalline Hydroxyapatite

Comparison of nanoparticular hydroxyapatite pastes of different particle content and size in a novel scapula defect model

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