Behavior of male-specific minor histocompatibility antigen in skin and limb transplantation

Muramatsu, Keiichi; Kurokawa, Yoko; Ihara, Kenji; Sakamoto, Soutetsu; Song, Yan; Kawai, Shinya

doi:10.1016/s0022-4804(03)00136-7

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…At the time of final evaluation, the patency of anastomosed pedicles was confirmed by a patency test under the operating microscope. The skin rejection of the grafted limb was diagnosed with the finding of reddish discoloration as reported before [15].…”

Section: Clinical Observationmentioning

confidence: 97%

“…All rats were obtained from Charles River Breeding Laboratories, Shizuoka, Japan. It has been found that graft transplantation from DA to Lewis rats produces a strong major histocompatibility mismatch, whereas male Lewis to female Lewis transplantation results in a minor mismatch as the result of Y-chromosome-based antigenic reactions [14,15].…”

Section: Animal Geneticsmentioning

confidence: 99%

“…Anesthesia was performed by intramuscular injection of ketamine chloride and xylazine cocktail. The rat hind limb replantation model previously described by us was used [15]. The donor right limb, including the bone, muscles, femoral vessels, sciatic nerve, and skin, were amputated at the midfemoral level.…”

Section: Transplantation Proceduresmentioning

confidence: 99%

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Donor cell engraftment in recipient lymphoid tissues after rat limb allograft

Muramatsu

Kurokawa

Ihara

et al. 2005

Journal of Surgical Research

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Section: Clinical Observationmentioning

confidence: 97%

Section: Animal Geneticsmentioning

confidence: 99%

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Donor cell engraftment in recipient lymphoid tissues after rat limb allograft

Muramatsu

Kurokawa

Ihara

et al. 2005

Journal of Surgical Research

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“…The previously described rat hindlimb replantation model was used. 7,8,18 The donor right limb, including the bone, muscles, femoral vessels, sciatic nerve, and skin, was amputated at midfemoral level. The skin distal to the knee joint was preserved to monitor circulation and skin rejection.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Gradual graft‐cell repopulation with recipient cells following vasularized bone and limb allotransplantation

Muramatsu¹,

Kurokawa²,

Kuriyama³

et al. 2005

Microsurgery

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Little is known about the fate of graft cells following vascularized bone allografting. This study was conducted to define the process of graft-cell repopulation with recipient cells. Sixty-five vascularized tibial bone and 50 limb allotransplantations were performed in rat sex-mismatched pairs. FK 506 was used for immunosuppression. The ratio of donor and recipient cells in the graft was evaluated by semiquantitative polymerase chain reaction, using the Y-chromosome primers. Allografted bones had no rejection episodes. In the vascularized bone allograft model, donor-derived cells were gradually replaced by cells of recipient origin, such that by 24 weeks, they comprised only 10% of total cells. In the limb allograft model, male recipient cells were detected in female grafts not at 1 week but at 48 weeks posttransplantation. The ratio of recipient cells was more than 10% in the femur and tibia. Recipient-derived cells gradually migrated into the grafted bone cells with the passage of time.

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“…17,18 Allogeneic hind limb transplantation is technically complex and leaves the recipient with a functional deformity. Because of these drawbacks, other possible bone marrow sources have been studied that are simple to access, do not include different type of tissues, and leave no deformity in the recipient.…”

mentioning

confidence: 99%

Chimerism induction in vascularized bone marrow transplants augmented with bone marrow cells

Arslan¹,

Klimczak²,

Siemionow³

2007

Microsurgery

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Composite tissue allografts (CTAs) are currently accepted in the clinic; however, long-term immunosuppression is still needed for allograft survival. The presence of donor-specific chimerism may induce tolerance. Thirty-six vascularized bone marrow transplantation (VBMT) allotransplantation were performed across MHC barrier under short-term protocol of 7-day alphabeta-TCRmAb and Cyclosporin A therapy to determine the efficacy of VBMT alone and VBMT augmented with donor bone marrow transplantation (BMT) in chimerism induction. Flow cytometry analysis revealed that VBMT supported with donor BMT directly into the bone resulted in chimerism augmentation and maintenance compared to VBMT. In vivo and in vitro tolerance testing showed prolonged survival of donor skin graft up to 35 days and moderate reactivity in MLR assay that suggests only tolerance induction. Transplantation of vascularized bone without chronic immunosuppression provides a substantial source of bone marrow cells, leading to the development of stable donor-specific chimerism.

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Behavior of male-specific minor histocompatibility antigen in skin and limb transplantation

Cited by 11 publications

References 24 publications

Donor cell engraftment in recipient lymphoid tissues after rat limb allograft

Donor cell engraftment in recipient lymphoid tissues after rat limb allograft

Gradual graft‐cell repopulation with recipient cells following vasularized bone and limb allotransplantation

Chimerism induction in vascularized bone marrow transplants augmented with bone marrow cells

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