Behavior of serum human major histocompatibility complex class I antigen levels in human immunodeficiency virus-infected patients during antiretroviral therapy: Correlation with clinical outcome

Murdaca, Giuseppe; Contini, Paola; Setti, Maurizio; Cagnati, Paola; Villa, Roberto; Lantieri, Francesca; Indiveri, Francesco; Puppo, Francesco

doi:10.1016/j.humimm.2007.09.008

Cited by 8 publications

(4 citation statements)

References 30 publications

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“…Moreover, the peripheral blood mononuclear cells (PBMC) from HIV‐infected individuals spontaneously shed a significantly higher amount of sHLA‐I molecules than peripheral blood mononuclear cells (PBMC) from HIV‐negative subjects. Most importantly, the sHLA‐I level in HIV patients decreased after 36 months of highly active anti‐retroviral therapy, which correlated with the increase in T cell population .…”

Section: Discussionmentioning

confidence: 97%

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Serum antibodies to human leucocyte antigen (HLA)-E, HLA-F and HLA-G in patients with systemic lupus erythematosus (SLE) during disease flares: Clinical relevance of HLA-F autoantibodies

Jucaud

Ravindranath

Terasaki

et al. 2015

Clinical and Experimental Immunology

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Summary T lymphocyte hyperactivity and progressive inflammation in systemic lupus erythematosus (SLE) patients results in over‐expression of human leucocyte antigen (HLA)‐Ib on the surface of lymphocytes. These are shed into the circulation upon inflammation, and may augment production of antibodies promoting pathogenicity of the disease. The objective was to evaluate the association of HLA‐Ib (HLA‐E, HLA‐F and HLA‐G) antibodies to the disease activity of SLE. The immunoglobulin (Ig)G/IgM reactivity to HLA‐Ib and β2m in the sera of 69 German, 29 Mexican female SLE patients and 17 German female controls was measured by multiplex Luminex®‐based flow cytometry. The values were expressed as mean florescence intensity (MFI). Only the German SLE cohort was analysed in relation to the clinical disease activity. In the controls, anti‐HLA‐G IgG predominated over other HLA‐Ib antibodies, whereas SLE patients had a preponderance of anti‐HLA‐F IgG over the other HLA‐Ib antibodies. The disease activity index, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)‐2000, was reflected only in the levels of anti‐HLA‐F IgG. Anti‐HLA‐F IgG with MFI level of 500–1999 was associated with active SLE, whereas inactive SLE revealed higher MFI (>2000). When anti‐HLA‐F IgG were cross‐reactive with other HLA‐Ib alleles, their reactivity was reflected in the levels of anti‐HLA‐E and ‐G IgG. The prevalence of HLA‐F‐monospecific antibodies in SLE patients was also associated with the clinical disease activity. Anti‐HLA‐F IgG is possibly involved in the clearance of HLA‐F shed from lymphocytes and inflamed tissues to lessen the disease's severity, and thus emerges as a beneficial immune biomarker. Therefore, anti‐HLA‐Ib IgG should be considered as a biomarker in standard SLE diagnostics.

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Section: Discussionmentioning

confidence: 97%

“…The observations of Murdaca et al . are very much to this point. This group reported that the serum level of sHLA‐I and sHLA‐G1 and ‐G5 molecules are higher in HIV‐positive subjects than in healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Serum antibodies to human leucocyte antigen (HLA)-E, HLA-F and HLA-G in patients with systemic lupus erythematosus (SLE) during disease flares: Clinical relevance of HLA-F autoantibodies

Jucaud

Ravindranath

Terasaki

et al. 2015

Clinical and Experimental Immunology

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“…The MHC is an extremely "gene-dense" region located on the short arm of chromosome 6p21.3. Human major histocompatibility complex class I antigens (HLA-A, -B, and -C) are heterodimeric molecules composed of a ␣ heavy chain noncovalently associated with an invariant protein known as ␤ 2 -microglobulin [20]. They are expressed on somatic cells as an identification of self/nonself.…”

Section: Discussionmentioning

confidence: 99%

Association of HLA class I alleles with keloids in Chinese Han individuals

Lu¹,

Cai²,

Wang³

et al. 2010

Human Immunology

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Keloids are benign fibroproliferative dermal tumors of unknown etiology. Some studies have suggested that human HLA status might potentiate development of keloids phenotype. No report has been published about HLA class I alleles associated with keloids in Chinese Han individuals. To investigate the etiology of keloids, the polymerase chain reaction-sequence-specific primer (PCR-SSP) method was used to analyze the distribution of HLA class I alleles in 192 patients with keloids and 252 healthy controls in a Chinese Han population. The frequencies of HLA-A*03 (6.77% vs 0%, p(c) < 10(-7)), A*25 (10.16% vs 4.56%, p(c) = 0.0111), B*07 (7.81% vs 2.58%, p(c) = 0.0080), and Cw*0802 (19.79% vs 10.32%, p(c) = 0.0004) were significantly increased in keloid patients, whereas the frequency of HLA-A*01 (18.75% vs 38.10%, p(c) < 10(-7)) was highly decreased, compared with that in healthy controls. The A*03-B*07, A*25-B*07, A*03-Cw*0802, A*25-Cw*0802, and B*07-Cw*0802 were found as high-risk haplotypes in developing keloids in this study. No extended haplotype was found to be significantly related to keloids. Through stratified analysis, the association of subgroups (single site/multiple site, severity, and family history) of keloid patients with specific HLA alleles was identified. Our data suggest these alleles may be keloids susceptibility genes or may be in close linkage with the susceptibility genes.

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“…Interestingly, both HLA-G membrane expression and sHLA-G serum levels are increased in viral infections, including influenza [14], hepatitis B and C [15,16], cytomegalovirus [17], and HIV-1 infections [18 -20]. We have previously reported that the serum levels of sHLA-A, -B, -C, and sHLA-G are significantly elevated in HIV-infected subjects, that their increase correlates with disease progression and development of the acquired immune deficiency syndrome (AIDS), and that their decrease significantly correlates with virologic and immunologic response to highly active antiretroviral therapy (HAART) [21][22][23]. At present, it is not known whether sHLA-G serum levels differ among patients with AIDS who have different AIDS-defining conditions.…”

Section: Introductionmentioning

confidence: 99%

Soluble human leukocyte antigen–G serum levels in patients with acquired immune deficiency syndrome affected by different disease-defining conditions before and after antiretroviral treatment

et al. 2011

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Behavior of serum human major histocompatibility complex class I antigen levels in human immunodeficiency virus-infected patients during antiretroviral therapy: Correlation with clinical outcome

Cited by 8 publications

References 30 publications

Serum antibodies to human leucocyte antigen (HLA)-E, HLA-F and HLA-G in patients with systemic lupus erythematosus (SLE) during disease flares: Clinical relevance of HLA-F autoantibodies

Serum antibodies to human leucocyte antigen (HLA)-E, HLA-F and HLA-G in patients with systemic lupus erythematosus (SLE) during disease flares: Clinical relevance of HLA-F autoantibodies

Association of HLA class I alleles with keloids in Chinese Han individuals

Soluble human leukocyte antigen–G serum levels in patients with acquired immune deficiency syndrome affected by different disease-defining conditions before and after antiretroviral treatment

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