Behavior of the Pharmacokinetics of Enrofloxacin in the Phase Space

Abstract

Phase space is an approach for analysis of nonlinear differential equations. The graphical solutions that are obtained are convenient for qualitative assessment of the behavior of systems and processes. A comparative analysis of the pharmacokinetics of the antibiotic enrofloxacin administered intravenously in dogs and cats has been performed in the present study. The mathematical models that represent the change in blood plasma concentration of the two groups of animals are described by second-order differential equations. For the graphical representation of phase trajectories using the fluoroquinolone, the Mathcad program tools are used. The properties of the peculiar points are determined based on the received images.