Behavioral Analysis of Cloned Puppies Derived from an Elite Drug-Detection Dog

Choi, Jin Nam; Lee, Ji Hyun; Oh, Hyun Ju; Kim, Min Jung; Park, Eun Jung; Jo, Yeonhwa; Lee, Sang Im; Hong, Do Gyo; Lee, Byeong Chun

doi:10.1007/s10519-013-9620-z

Cited by 13 publications

(19 citation statements)

References 16 publications

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“…In contrast, in the control group all of the drives and the means were inconsistent. Our previous study showed that cloned puppies could be classified into the same group by the Campbell test (Choi et al 2014), and the behaviours of the cloned group were more consistent than those of the control group in this study. While our previous study was conducted with Labrador Retrievers, this study was performed with Beagles.…”

Section: Discussionsupporting

confidence: 63%

“…In contrast, other results showed that fear, anxiety and aggression behaviours were not consistent (Stephen and Ledger 2007). The behaviour of cloned dogs has been studied to determine the similarities among animals (Choi et al 2014), and the present study attempted to assess the personality consistency of cloned dogs. This investigation was conducted by comparing cloned and control groups for consistency of their Puppy Aptitude Test (PAT) scores.…”

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confidence: 86%

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Personality consistency analysis in cloned quarantine dog candidates

et al. 2017

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In recent research, personality consistency has become an important characteristic. Diverse traits and human-animal interactions, in particular, are studied in the field of personality consistency in dogs. Here, we investigated the consistency of dominant behaviours in cloned and control groups followed by the modified Puppy Aptitude Test, which consists of ten subtests to ascertain the influence of genetic identity. In this test, puppies are exposed to stranger, restraint, prey-like object, noise, startling object, etc. Six cloned and four control puppies participated and the consistency of responses at ages 7-10 and 16 weeks in the two groups was compared. The two groups showed different consistencies in the subtests. While the average scores of the cloned group were consistent (P = 0.7991), those of the control group were not (P = 0.0089). Scores of Pack Drive and Fight or Flight Drive were consistent in the cloned group, however, those of the control group were not. Scores of Prey Drive were not consistent in either the cloned or the control group. Therefore, it is suggested that consistency of dominant behaviour is affected by genetic identity and some behaviours can be influenced more than others. Our results suggest that cloned dogs could show more consistent traits than non-cloned. This study implies that personality consistency could be one of the ways to analyse traits of puppies. Canine behaviour, cloned dog, puppy aptitude testMuch effort has been made to assess the personalities of dogs to predict the temperaments of companion animals and to select working dogs more efficiently. Potential dog owners likely want to know their family member's expected characteristics. Bartlett (1979) explained how to select a family dog using the Puppy Aptitude Test. Adopting suitable animals could be the beginning of a happy life for both owners and the dogs. Breeders need to check the puppies' temperaments for similar reasons for their future dog owners. Training institutions that produce excellent working dogs focused on selecting candidates at an early age to save money and time. Svartberg et al. (2005) investigated the consistency of dogs' behaviours using a standardized behavioural test and could deduce stable traits such as playfulness, chase-proneness and sociability. Substantial consistency of dogs' personalities was reported by Fratkin et al. (2013), who determined the factors that influence consistency as the age, interaction between temperament and age, and length of time interval between tests. These authors did not, however, estimate the influence of the genetic background on consistency (Fratkin et al. 2013). Bartlett (1979) used 10 subtests to analyse puppies' behaviours, including social attraction, dominant or submissive tendency under stress, willingness to work with humans and sensitivities. Volhard and Volhard (2001) divided the subtests into three drives,

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Section: Discussionsupporting

confidence: 63%

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confidence: 86%

Personality consistency analysis in cloned quarantine dog candidates

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“…The canine SCNT technique has been notably improved since Snuppy, the first cloned dog, was born in 2005 (Lee et al., ). This achievement made canine SCNT applicable to various fields such as conservation of endangered species (Choi et al, ; Jang et al, ; Kim et al, ; Oh et al., ), elite working dogs (Choi et al., ; Oh et al., , ) and animal model researches (Hong et al., ; Kim et al., , ).…”

Section: Application Of Canine Scntmentioning

confidence: 99%

“…Through the 10 subtests for puppy aptitude test, they exhibited a similar tendency for the test with the same behaviour type, although these cloned dogs did not show a perfectly identical score for test. Also, in another research, seven cloned detection puppies were analysed for their similarities in behaviour and the ability for drug detection (Choi et al., ). In this study, Campbell test which is generally used to evaluate the dominance tendency was applied for performing behavioural test.…”

Section: Introductionmentioning

confidence: 99%

Dog cloning—no longer science fiction

Lee

Kim

et al. 2018

Reprod Domestic Animals

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Contents Since the generation of world's first cloned dog, Snuppy, in 2005, somatic cell nuclear transfer (SCNT) in dogs has been widely applied for producing several kinds of dogs with specific objectives. Previous studies have demonstrated that cloned dogs show normal characteristics in growth, blood parameters and behavioural aspect. Also, canine SCNT technique has been applied to propagate working dogs with excellent abilities in fields such as assistance of disabled people, drugs detection and rescue activity. Because dogs have similar habituation properties and share many characteristics including anatomic and physiological aspects with humans, they are also primary candidates for human disease models. Recently, transgenic dogs that express red fluorescent protein gene constitutively and green fluorescent protein gene conditionally have been generated. In addition, transgenic dogs with an overexpression of peroxisome proliferator‐activated receptor‐alpha in specific muscles were generated to enhance physical performance. In 2017, Snuppy was recloned with markedly increased pregnancy and delivery rates compared to the statistics from when Snuppy was first cloned. Such striking improvements in the cloning of dogs using SCNT procedures suggest that dog cloning could be applied in many fields of biomedical science for human diseases research, and the application of cloning is no longer science fiction.

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“…For propagation of dogs with elite abilities, seven cloned drug-sniffing dogs were produced using donor cells from a dog possessing a distinct ability to concentrate and identify specific smells among countless other scents [22]. These cloned dogs displayed similar behavioral patterns, achieved a 100% rate in the selection test for becoming a drug detection dog, and obtained higher scores for the selection test than other naturally bred dogs [7]. However, there is little information available regarding behavioral similarities such as learning, memory and exploratory patterns in cloned dogs.…”

Section: Introductionmentioning

confidence: 99%

Learning, memory and exploratory similarities in genetically identical cloned dogs

Shin

Park

et al. 2016

J Vet Sci

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Somatic cell nuclear transfer allows generation of genetically identical animals using donor cells derived from animals with particular traits. To date, few studies have investigated whether or not these cloned dogs will show identical behavior patterns. To address this question, learning, memory and exploratory patterns were examined using six cloned dogs with identical nuclear genomes. The variance of total incorrect choice number in the Y-maze test among cloned dogs was significantly lower than that of the control dogs. There was also a significant decrease in variance in the level of exploratory activity in the open fields test compared to age-matched control dogs. These results indicate that cloned dogs show similar cognitive and exploratory patterns, suggesting that these behavioral phenotypes are related to the genotypes of the individuals.

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Behavioral Analysis of Cloned Puppies Derived from an Elite Drug-Detection Dog

Cited by 13 publications

References 16 publications

Personality consistency analysis in cloned quarantine dog candidates

Personality consistency analysis in cloned quarantine dog candidates

Dog cloning—no longer science fiction

Learning, memory and exploratory similarities in genetically identical cloned dogs

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