Behavioral and anticonvulsant effects of the standardized extract of Ficus platyphylla stem bark

Chindo, Ben A.; Ya’u, Jamilu; Danjuma, Nuhu M; Okhale, Samuel; Gamaniel, K.; Becker, Axel

doi:10.1016/j.jep.2014.03.061

Cited by 34 publications

(35 citation statements)

References 53 publications

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“…Isonicotinic acid Hydrazide (INH) is thought to inhibit GABA synthesis in CNS 12,15 . Group I: Animals were maintained as a negative control, which was given distilled water ( …”

Section: Isonicotinic Acid Hydrazide Induced Convulsion In Micementioning

confidence: 99%

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of Achillea fragrantissima (Gaisoom) Extracts Growing in Saudi Arabia

Mudawi

El-wahab

Yassin

et al. 2017

AJPRHC

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In Kingdom of Saudi Arabia Achillea fragrantissima is a fragrant, perennial herb has long been used medicinally for its analgesic properties among Rafha residents. The present study concluded that Achillea fragrantissima (Gaisoom) possess a potent anticonvulsant activity against PTZ induced seizures which may be due to GABAA agonistic activity and /or antioxidant activity. The results of the current study showed that the ethanolic extract of Gaisoom at doses of 300 mg/kg and 600 mg/kg has anticonvulsant activity in pentylenetetrazole and maximum electroshock induced seizures models on mice. The Hexane extract have protected the mice against pentylenetetrazole -induced seizures with 100% protection rate and 100% animal survival similar to the anticonvulsant drug phenobarbital. HPLC-DAD fingerprints of different fractions were also carried out to find the pharmacological active compound. The studies are in progress to isolate the compounds by HPLC technique. Supplementary studies are required to explain the exact mechanism of action by which Gaisoom act as an anticonvulsant agent.

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“…Isonicotinic acid Hydrazide (INH) is thought to inhibit GABA synthesis in CNS 12,15 . Group I: Animals were maintained as a negative control, which was given distilled water ( …”

Section: Isonicotinic Acid Hydrazide Induced Convulsion In Micementioning

confidence: 99%

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of Achillea fragrantissima (Gaisoom) Extracts Growing in Saudi Arabia

Mudawi

El-wahab

Yassin

et al. 2017

AJPRHC

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“…Other plants like Adansonia digitata have been scientifically validated for several pharmacological activities including nutritional, anti-inflammatory, antibacterial and analgesic among others (De Caluwe et al, 2010). The plant Ficus platyphylla has been evaluated for other central nervous system and neurological disorders such as epilepsy and sedation (Chindo et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Ethno-botanical survey of medicinal plants used for the management of depression by Hausa tribes of Kaduna State, Nigeria

Shehu¹,

Magaji²,

Ya’u³

et al. 2017

J. Med. Plants Res.

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The objective of this study is to conduct an ethnobotanical survey of medicinal plants used in management of depression among Hausa tribes in order to establish an informational data base. An ethnobotanical survey was conducted in December 2015 in Zaria, Kaduna State, Nigeria. Data were collected based on an oral interview with the aid of semi structured questionnaire. Only data from willing respondents were obtained and documented. Plant specimens were collected along the line, they were subsequently dried and mounted. It was then taken for identification and authentication in the Herbarium Section of Biological Sciences, Ahmadu Bello University, Zaria where specimen voucher numbers were deposited. Information on sources, safety, methods of preparation and administrations, identity, local and botanical names of medicinal plants used in the management of depression among Hausa tribe of Kaduna State was obtained. An informational database was established and specimen with voucher numbers was deposited in the herbarium.

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“…[14,15]. TCM is often considered to be a gentle and safe way to synthetically manufacture drugs, and it is the most widely practiced form of herbalism worldwide [7].…”

Section: Discussionmentioning

confidence: 99%

“…MES and PTZ tests are used to identify anticonvulsant effect against petit mal seizures and generalized tonic-clonic seizures [12,17]. The effects of FCP against PTZ-induced seizures suggested the anticonvulsant efficacy against epilepsy in humans.…”

Section: Discussionmentioning

confidence: 99%

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Anticonvulsant and sedative effect of Fufang Changniu pills and probable mechanism of action in mice

Zhang¹,

Lu²,

Zhang³

et al. 2016

Trop. J. Pharm Res

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Behavioral and anticonvulsant effects of the standardized extract of Ficus platyphylla stem bark

Cited by 34 publications

References 53 publications

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

Ethno-botanical survey of medicinal plants used for the management of depression by Hausa tribes of Kaduna State, Nigeria

Anticonvulsant and sedative effect of <i>Fufang Changniu</i> pills and probable mechanism of action in mice

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