Behavioral and biochemical adjustments of the zebrafish Danio rerio exposed to the β-blocker propranolol

Mitchell, Kimberly; Moon, Thomas W.

doi:10.1016/j.cbpb.2015.10.009

Cited by 24 publications

(14 citation statements)

References 52 publications

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“…Consequently, various cardiovascular drugs have been extensively used in the past few decades. Beta-blockers, or β-blockers, are predominantly used to treat cardiovascular disease [1,2]. Their widespread application, as well as incomplete removal during wastewater treatment [3], result in them occurring in various aquatic environments [2,[4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Beta-blockers, or β-blockers, are predominantly used to treat cardiovascular disease [1,2]. Their widespread application, as well as incomplete removal during wastewater treatment [3], result in them occurring in various aquatic environments [2,[4][5][6][7]. Propranolol has been detected extensively in the water compartment at low concentrations in the ng/L range as it is a commonly used β-blocker [2,8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Their widespread application, as well as incomplete removal during wastewater treatment [3], result in them occurring in various aquatic environments [2,[4][5][6][7]. Propranolol has been detected extensively in the water compartment at low concentrations in the ng/L range as it is a commonly used β-blocker [2,8,9]. Although designed for human use, more and more evidence has indicated that propranolol may pose harm to aquatic organisms [10][11][12][13][14][15], it must be pointed out that propranolol has shown high hydrolytic stability [16].…”

Section: Introductionmentioning

confidence: 99%

“…Although designed for human use, more and more evidence has indicated that propranolol may pose harm to aquatic organisms [10][11][12][13][14][15], it must be pointed out that propranolol has shown high hydrolytic stability [16]. Meanwhile, propranolol may bioaccumulate in water ecosystems due to its lipophilicity [2,3,17]. Therefore, it is urgent that various efficient methods are developed to remove propranolol from water.…”

Section: Introductionmentioning

confidence: 99%

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Surface-Bound Humic Acid Increased Propranolol Sorption on Fe3O4/Attapulgite Magnetic Nanoparticles

Deng

2020

Nanomaterials

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This study explored the feasibility of utilizing a novel sorbent humic acid (HA) coated Fe3O4/attapulgite (MATP) magnetic nanoparticles (HMATP) for the sorption of propranolol from aqueous solutions. MATP and bare Fe3O4 nanoparticles were also synthesized under similar preparation conditions. The FTIR, Zeta potential, XRD, VSM, TEM, and TGA analyses were conducted to characterize the sorbent materials. The effects of pH, sorbent dosage, ionic strength, HA in the aqueous solution, contact time and initial sorbate concentration on sorption of propranolol were investigated using batch sorption experiments. The results suggested that the sorption capacity of HMATP showed little change from pH 4 to 10. Na+ and Ca2+ slightly inhibited the sorption of propranolol on HMATP. While HA in solution enhanced both MATP and HMATP, which indicated that HMATP can resist HA interference in water. Further, the less leaching amounts of Fe and HA suggested a good stability of HMATP. In all conditions, sorption capacity of propranolol on HMATP was obviously higher than that on MATP, which indicated that surface-coated HA played an important role in the propranolol sorption process. Electrostatic interaction, cation exchange, hydrogen bonding, and π–π electron donor acceptor interactions were considered as the sorption mechanisms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surface-Bound Humic Acid Increased Propranolol Sorption on Fe3O4/Attapulgite Magnetic Nanoparticles

Deng

2020

Nanomaterials

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“…The occurrence of pharmaceutical products that are found at concentrations between ng/L to µg/L in wastewater effluents could also impact the neurophysiological status in fish and other vertebrates. In another study, Danio rerio larvae exposed to environmentally relevant concentrations of propranolol, a β-blocker for the treatment of hypertension, had reduced testosterone and estradiol-17β and showed a more passive behavior compared to control larvae [10]. This raises the question that exposure to municipal effluent could also impede at the neurological level in fish as well.…”

Section: Introductionmentioning

confidence: 99%

Neurotoxicological Effects of Municipal Effluents in Fathead Minnow Pimephale Promelas

Gagné¹,

Trépanier²,

André³

2016

EPP

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Municipal effluents are known to be able of disrupting neuro-endocrine signaling pathways in oviparous organisms. The purpose of this study was to examine the neurotoxicity of a chemically-treated municipal effluent to adult fathead minnow (Pimephales promelas) after 21 days. Brain somatic index and lipid peroxidation (LPO), monoamine oxidase (MAO) and acetylcholinesterase (AChE) levels were determined in both male and female fish. The estrogenicity of the municipal effluent was confirmed by measuring vitellogenin production and energy expenses in the liver. Brain MAO and AChE activities increased at low effluent concentrations and decreased at higher concentrations (>10% v/v). The data suggest that males expend more metabolic energy than females and was related to vitellogenin, and that brain activity is impaired in both sexes in the presence of the effluent. In conclusion, exposure to municipal effluents could produce biochemical changes in the central nervous system in fish.

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Effects of Age and Exposure Duration on the Sensitivity of Early Life Stage Fathead Minnow (Pimephales promelas) to Waterborne Propranolol Exposure

Biales,

Bencic,

Flick

et al. 2024

Enviro Toxic and Chemistry

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Propranolol is a heavily prescribed, non‐specific beta‐adrenoceptor (bAR) antagonist frequently found in wastewater effluents, prompting concern over its potential to adversely affect exposed organisms. Herein, the transcriptional responses of 4, 5, and 6 dpf +/‐ 1h fathead minnow (FHM), exposed for 6, 24, or 48hr to 0.66 or 3.3mg/L (nominal) propranolol were characterized using RNA‐seq. The number of differentially expressed genes (DEGs) was used as an estimate of sensitivity. A trend toward increased sensitivity with age was observed; fish >7dpf at the end of exposure were particularly sensitive to propranolol. DEGs largely overlapped among treatment groups, suggesting a highly consistent response that was independent of age. Cluster analysis was performed using normalized count data for unexposed and propranolol exposed fish. Control fish clustered tightly by age, with fish >= 7dpf clustering away from younger fish, reflecting developmental differences. When clustering was conducted using exposed fish, in cases where propranolol induced a minimal or no transcriptional response, results mirrored those of the control fish and did not appreciably cluster by treatment. In treatment groups that displayed a more robust transcriptional response, the effects of propranolol were evident, however, fish < 7dpf clustered away from older fish, despite having similar numbers of DEGs. Increased sensitivity at 7dpf coincided with developmental milestones with the potential to alter propranolol pharmacokinetics or pharmacodynamics, such as the onset of exogenous feeding and gill functionality, as well as increased systemic expression of bAR. These results may have broader implications, as toxicity testing often utilizes fish < 4dpf, prior to the onset of these potentially important developmental milestones, which may result in an underestimation of risk for some chemicals.

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Behavioral and biochemical adjustments of the zebrafish Danio rerio exposed to the β-blocker propranolol

Cited by 24 publications

References 52 publications

Surface-Bound Humic Acid Increased Propranolol Sorption on Fe3O4/Attapulgite Magnetic Nanoparticles

Surface-Bound Humic Acid Increased Propranolol Sorption on Fe3O4/Attapulgite Magnetic Nanoparticles

Neurotoxicological Effects of Municipal Effluents in Fathead Minnow Pimephale Promelas

Effects of Age and Exposure Duration on the Sensitivity of Early Life Stage Fathead Minnow (Pimephales promelas) to Waterborne Propranolol Exposure

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