Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction

Li, Jianmei; Kong, Ling-Dong; Wang, Yemin; Chen, Cheng; Zhang, Weiyun; Tan, Wen-Zhi

doi:10.1016/j.lfs.2003.06.030

Cited by 89 publications

(55 citation statements)

References 65 publications

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“…3,7,14,27) Many researchers have reported that IL-6 administration activities the HPA axis and TNF-a also enhances HPA activation. [14][15][16] In the present study, CMStreated rats were characterized by higher CRF levels in serum and medulla oblongata, accompanied by significantly increased serum cortisol levels.…”

Section: Discussionmentioning

confidence: 99%

“…[25][26][27] Each week consisted of one period (12 h) of paired caging, two periods (14, 18 h) of tilting cage (45°), two periods of water and food deprivation (14, 18 h), one 12-h period with a wet cage (200 ml of water in 100 g of sawdust bedding), and two periods (12 h each) of continuous light, three periods (6, 10, 12 h) of low-intensity stroboscopic illumination (150 flashes/min), one 12-h period of intermittent illumination (2-h/2-h light/dark cycle), two periods of noise (6300-Hz tone, 10, 12 h). All of the stressors were applied individually and continuously, day and night.…”

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confidence: 99%

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Ethanolic Extracts from Curcuma longa Attenuates Behavioral, Immune, and Neuroendocrine Alterations in a Rat Chronic Mild Stress Model

Xia

Pan

Zhang

et al. 2006

Biological & Pharmaceutical Bulletin

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Evidence suggests an association between depressive disorders and immune and neuroendocrine alterations.1) Cytokines, signaling molecules of the cellular immune system, profoundly influence neuroendocrine processes, thereby promoting affective disorders. [2][3][4] Interleukin (IL) 6 and tumor necrosis factor-alpha (TNF-a), mainly derived from activated macrophages, are pleiotropic cytokines. Increased serum IL-6 levels have been observed in depressed patients, which were reversed after treatment with antidepressant drugs such as fluoxetine.5,6) Elevated circulating TNF-a might be associated with psychiatric illness. 7) In addition to activation of cytokine secretion, a reduction in natural killer (NK) cell activity has also been reported in depressive patients.8) NK cell activity could be reversed by antidepressant drugs concomitant with clinical improvement in patents with depression. 1,9) There are complex reciprocal relationships between immune and hypothalamic-pituitary-adrenal (HPA) axis function in depression.10,11) Elevated cerebrospinal fluid corticotropin-releasing factor (CRF) concentrations and altered regulation of adrenocorticotropin hormone (ACTH) and cortisol secretory activities have been observed in patients with major depression.12) Normalization of these levels occurred after successful antidepressant treatment with fluoxetine.13) On the other hand, some cytokines are known to be potent activators of the HPA axis and involved in the regulation of cortisol and ACTH secretion. It was important to note that animals displaying IL-6-and TNF-a-induced HPA axis sensitization showed signs of marked illness.14,15) In addition, NK cell activity is mediated by pro-inflammatory cytokines, mainly by IL-6 and TNF-a, which in depressed patients appear to be correlated with severity of the disease and hyperactivity of the HPA axis.11,16) These findings indicated that modulation of immune activities appeared to be in part under the control of the HPA axis.16)The rhizomes of Curcuma longa L. (Zingiberaceae), commonly called turmeric, are widely used in food and medicine. Turmeric extracts have been shown to possess powerful antioxidant, anti-inflammatory, lipid-reducing, chemopreventive, immunodulatory, and sedative actions.17,18) Current pharmacological studies show that they may represent a potential therapeutic approach to ameliorate the progression of Alzheimer's disease. [19][20][21] Clinical results have recently suggested that premorbid major depressive disorder is associated with more severe cognitive deficits during the actual course of dementia.22) Our previous study demonstrated that aqueous extracts of C. longa were able to elicit a dose-dependent immobility reduction in the tail suspension test and the forced swimming test in mice, two animal models of depression.23) Curcumin, a major compound of the ethanolic extracts in turmeric, was found to attenuate the monoamine oxidase activity in C6 glial cells. 24) In our continuing efforts to discover a suitable pharmacological therapy for treating depres...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Ethanolic Extracts from Curcuma longa Attenuates Behavioral, Immune, and Neuroendocrine Alterations in a Rat Chronic Mild Stress Model

Xia

Pan

Zhang

et al. 2006

Biological & Pharmaceutical Bulletin

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“…Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions traditional Chinese medicine (TCM) and many TCM compounds are receiving more attention for their extensive applications in China (Luo et al, 2000;Li et al, 2003;Peng et al, 2007;An et al, 2008a,b;Zhang et al, 2009;Kwon et al, 2010;Mao et al, 2010;Zhou et al, 2010).…”

Section: Research Articlementioning

confidence: 99%

Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions

Aimin¹,

Ma²,

Zhang³

et al. 2012

Pharmaceutical Biology

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“…This is confirmed by the fact that NOS inhibition modulates central serotonin release (Kiss, 2000;Smith&Whitton, 2000;Wegener et al, 2000). In rats exposed to chronic mild stress, 5-HT and 5-HIAA (5-hydroxy indol acetic acid) levels decreased significantly in many brain regions, compared to nonstressed animals (Li et al, 2003;Vancassel et al, 2008). Therefore, it can be the fact that effects of TRIM might be explained by its ability to reverse the UCMS-induced alteration of 5-HT. )…”

Section: Effects Of Nos Inhibitors In Depressionmentioning

confidence: 93%

New Approaches for the Therapy of Treatment Refractory Depression

Mutlu¹,

Ulak²,

Çelikyurt³

et al. 2012

Psychology - Selected Papers

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Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction

Cited by 89 publications

References 65 publications

Ethanolic Extracts from Curcuma longa Attenuates Behavioral, Immune, and Neuroendocrine Alterations in a Rat Chronic Mild Stress Model

Ethanolic Extracts from Curcuma longa Attenuates Behavioral, Immune, and Neuroendocrine Alterations in a Rat Chronic Mild Stress Model

Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions

New Approaches for the Therapy of Treatment Refractory Depression

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