Behavioral and Cognitive Consequences of Obesity in Parents and Offspring in Female and Male Rats: Implications of Neuroinflammation and Neuromodulation

Demir, Enver Ahmet; Gülbol-Duran, Gülay; Urhan-Kucuk, Meral; Doğan, Hatice; Tutuk, Okan; Çimen, Funda; Bayirli, Mucella; Tümer, Cemıl; Duran, Nizami

doi:10.1007/s12035-022-02831-5

Cited by 6 publications

(2 citation statements)

References 114 publications

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“…This is consistent with a previous study in humans, whereby if both parents were obese, their children had more difficulty with problem solving, compared to when neither parent was obese or only one parent was obese (Yeung et al, 2017). A recent study in Wistar rats also found that being born to obese parents led to a decline in spatial memory (Demir et al, 2022). Furthermore, studies in rodents by McPherson et al (2015) and Finger et al (2015) demonstrated that when both parents were obese, there were seemingly greater negative impacts on offspring health than either paternal or maternal obesity alone.…”

Section: Intergenerational Effects On Aversive Learningsupporting

confidence: 91%

Intergenerational effects of overfeeding on aversive learning in zebrafish (Danio rerio)

Anwer¹,

Mason²,

Zajitschek³

et al. 2022

Preprint

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The obesity epidemic is among the most serious and rapidly growing public health challenges of the 21st century. This rapid increase is concerning as obesity appears to negatively impact cognition and behaviour. Furthermore, some studies suggest that this negative effect could be carried across generations from both mothers and fathers although evidence is not consistent. Here, we attempt to address how obesogenic diets in the parental generation (F0) can impact offspring’s cognition and anxiety intergenerationally (F1) in a zebrafish model. We compare both mean trait values and their variances. Using a multifactorial design, we created a total of four groups: F1T (treatment mothers x treatment fathers); F1M (treatment mothers x control fathers); F1P (treatment fathers x control mothers); and F1C (control mothers x control fathers, F1C); and subjected them to anxiety tank tests and aversive learning assays. When both parents were exposed, offspring (F1T) displayed the poorest aversive learning, while offspring that only had one parent exposed (F1P and F1M) learnt the aversive learning task the best. Zebrafish in all groups displayed no statistically significant differences in anxiety-associated behaviours. Males and females also performed similarly in both anxiety and aversive learning assays. While all F1 groups had similar levels of fasting blood glucose, variance in glucose levels were reduced in F1P and F1T indicating the importance of investigating heteroskedasticity between groups. Furthermore, anxiety behaviours of these two groups appeared to be less repeatable. To our knowledge, this is the first study to test the intergenerational effects of an obesogenic diet on zebrafish cognition. Our multifactorial design as well as repeated tests also allowed us to disentangle maternal and paternal effects (as well as combined effects) and accurately detect subtle information such as between-individual variation. However, our work is restricted to aversive learning. It would be interesting to see whether appetitive and other types of learning produce similar results in zebrafish offspring.

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Section: Intergenerational Effects On Aversive Learningsupporting

confidence: 91%

Intergenerational effects of overfeeding on aversive learning in zebrafish (Danio rerio)

Anwer¹,

Mason²,

Zajitschek³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…This is consistent with a previous study in humans, whereby if both parents were obese, their children had more difficulty with problem solving, compared to when neither parent was obese or only one parent was obese (Yeung et al, 2017 ). A recent study in Wistar rats also found that being born to obese parents led to a decline in spatial memory (Demir et al, 2022 ). Furthermore, studies in rodents by McPherson et al ( 2015 ) and Finger et al ( 2015 ) demonstrated that when both parents were obese, there were seemingly greater negative impacts on offspring health than either paternal or maternal obesity alone.…”

Section: Discussionmentioning

confidence: 95%

Intergenerational effects of overfeeding on aversive learning in zebrafish (Danio rerio)

Anwer

Mason

Zajitschek

et al. 2022

Ecology and Evolution

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A comparative study of Western, high-carbohydrate, and standard lab diet consumption throughout adolescence on metabolic and anxiety-related outcomes in young adult male and female Long-Evans rats

Myles

Hamm²,

Allden³

et al. 2023

Behavioural Brain Research

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Behavioral and Cognitive Consequences of Obesity in Parents and Offspring in Female and Male Rats: Implications of Neuroinflammation and Neuromodulation

Cited by 6 publications

References 114 publications

Intergenerational effects of overfeeding on aversive learning in zebrafish (Danio rerio)

Intergenerational effects of overfeeding on aversive learning in zebrafish (Danio rerio)

Intergenerational effects of overfeeding on aversive learning in zebrafish (Danio rerio)

A comparative study of Western, high-carbohydrate, and standard lab diet consumption throughout adolescence on metabolic and anxiety-related outcomes in young adult male and female Long-Evans rats

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