Behavioral and neurochemical consequences of multiple MDMA administrations in the rat: Role of individual differences in anxiety-related behavior

Ludwig, Verena; Mihov, Yoan; Schwarting, Rainer K.W.

doi:10.1016/j.bbr.2007.12.008

Cited by 30 publications

(24 citation statements)

References 84 publications

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“…Numerous behavioral paradigms have been set up over the years to assess the anxiety levels of rodents. Our results are in line with a previous report showing that Wistar rats exhibiting less anxiety-like behavior in an EPM test developed higher levels of sensitization to MDMA (Ludwig et al, 2008). Basal anxiety-like behavior evaluated in the light/dark box.…”

Section: Discussionsupporting

confidence: 93%

Basal Anxiety Negatively Correlates with Vulnerability to Ethanol‐Induced Behavioral Sensitization in DBA/2J Mice: Modulation by Diazepam

Botia

Legastelois

Houchi

et al. 2015

Alcoholism Clin & Exp Res

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This study shows that, in mice, basal anxiety predicts the vulnerability to EIBS. Mice exhibiting low basal anxiety will develop higher EIBS than mice with elevated anxiety levels. Modulation of anxiety by a diazepam treatment during the development of EIBS enhances its expression after 1 week postinduction. Altogether, we demonstrated an inverse relationship between basal anxiety-like behaviors and EIBS vulnerability and that resistance to EIBS vanishes after anxiolytic treatment.

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Section: Discussionsupporting

confidence: 93%

Basal Anxiety Negatively Correlates with Vulnerability to Ethanol‐Induced Behavioral Sensitization in DBA/2J Mice: Modulation by Diazepam

Botia

Legastelois

Houchi

et al. 2015

Alcoholism Clin & Exp Res

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“…Sedative effects of moderate to high doses of GHB are well documented (van Nieuwenhuijzen et al 2009b) as is the gradual development of tolerance to such effects with repeated administration in mice (Itzhak and Ali 2002) and rats (Bania et al 2003). In contrast, MDMA administration resulted in hyperactivity, with some evidence of sensitization effects with repeated administration, as has been previously demonstrated (Colussi-Mas and Schenk 2008;Ludwig et al 2008). However, overall sensitization effects were small in magnitude and may have been greater had an Fig.…”

Section: Discussionmentioning

confidence: 67%

Residual social, memory and oxytocin-related changes in rats following repeated exposure to γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination

et al. 2010

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“…It also produces a marked increase in metabolic activity, free radical production and oxidative stress [3]. The acute effects of MDMA last for 3 to 5 hours in humans, and they include euphoria, relaxation, an increase in sociability, empathy and energy [4], [5]. Ecstasy users also show other physiological modifications, such as body temperature deregulation and weight loss [6], [7].…”

Section: Introductionmentioning

confidence: 99%

Sex-Dependent Psychoneuroendocrine Effects of THC and MDMA in an Animal Model of Adolescent Drug Consumption

et al. 2013

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Ecstasy is a drug that is usually consumed by young people at the weekends and frequently, in combination with cannabis. In the present study we have investigated the long-term effects of administering increasing doses of delta-9-tetrahydrocannabinol [THC; 2.5, 5, 10 mg/kg; i.p.] from postnatal day (pnd) 28 to 45, alone and/or in conjunction with 3,4-methylenedioxymethamphetamine [MDMA; two daily doses of 10 mg/kg every 5 days; s.c.] from pnd 30 to 45, in both male and female Wistar rats. When tested one day after the end of the pharmacological treatment (pnd 46), MDMA administration induced a reduction in directed exploration in the holeboard test and an increase in open-arm exploration in an elevated plus maze. In the long-term, cognitive functions in the novel object test were seen to be disrupted by THC administration to female but not male rats. In the prepulse inhibition test, MDMA-treated animals showed a decrease in prepulse inhibition at the most intense prepulse studied (80 dB), whereas in combination with THC it induced a similar decrease at 75 dB. THC decreased hippocampal Arc expression in both sexes, while in the frontal cortex this reduction was only evident in females. MDMA induced a reduction in ERK1/2 immunoreactivity in the frontal cortex of male but not female animals, and THC decreased prepro-orexin mRNA levels in the hypothalamus of males, although this effect was prevented when the animals also received MDMA. The results presented indicate that adolescent exposure to THC and/or MDMA induces long-term, sex-dependent psychophysiological alterations and they reveal functional interactions between the two drugs.

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Behavioral and neurochemical consequences of multiple MDMA administrations in the rat: Role of individual differences in anxiety-related behavior

Cited by 30 publications

References 84 publications

Basal Anxiety Negatively Correlates with Vulnerability to Ethanol‐Induced Behavioral Sensitization in DBA/2J Mice: Modulation by Diazepam

Basal Anxiety Negatively Correlates with Vulnerability to Ethanol‐Induced Behavioral Sensitization in DBA/2J Mice: Modulation by Diazepam

Residual social, memory and oxytocin-related changes in rats following repeated exposure to γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination

Sex-Dependent Psychoneuroendocrine Effects of THC and MDMA in an Animal Model of Adolescent Drug Consumption

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