Behavioral and neurochemical indices of barrel cortex-basal ganglia interaction

Tactile sensory input regulates basal and apomorphine‐induced immediate‐early gene expression in rat barrel cortex

“…Stimulation or removal of vibrissae has been found to increase or decrease, respectively, glucose consumption in related barrels (Durham and Woolsey, 1978;Melzer et al, 1985;Chmielowska et al, 1986). Involvement of the barrel cortex in sensorimotor functions is suggested by the finding that lesions in the barrel field produce similar behavioral deficits as seen after vibrissae removal (Adams et al, 1992). While some of the behavioral deficits after vibrissae removal can be seen during exploratory behavior (lateralized facial scanning), turning and scanning asymmetries are more pronounced, or are seen exclusively, under the influence of drugs such as apomorphine.…”

Automated Video-Image Analysis of Behavioral Asymmetries

“…Accordingly, our previous work has shown that thigmotactic scanning can serve as a sensitive indicator of asymmetry both after unilateral vibrissae removal (e.g., Steiner et al, 1986;Milani et al, 1990) and after unilateral lesions of the nigrostriatal DA system (Steiner et al, 1988;Mattioli et al, 1992;Fornaguera et al, 1993Fornaguera et al, , 1994. Furthermore, the measure of thigmotactic scanning may provide an interesting behavioral variable for those working on functional aspects of the trigemino-thalamo-cortical representation of the vibrissae, since this measure is also sensitive, for example, to lesions of the barrel cortex (Adams et al, 1992).…”

“…However, several studies using unilateral sensory manipulations or even brain-damaged animals have pointed to the importance of sensory mechanisms determining the direction of asymmetry in an animal, and it has been repeatedly demonstrated that the direction of behavioral asymmetry can be dependent on the kind of testing environment and the presence of walls and edges within or surrounding it (e.g., Szechtman, 1983;Pisa and Szechtman, 1986;Ziegler and Szechtman, 1988). Furthermore, the investigation of thigmotactic scanning has shown that it can be lateralized by several unilateral manipulations, and that the direction and time-course of asymmetry depend on the kind of treatment, which includes sensory manipulation (e.g., vibrissae removal; Steiner et al, 1986), lesion of the barrel cortex (Adams et al, 1992), trephination of the overlying skull (Adams et al, 1994), chemical stimulation in the brain (Wise and Holmes, 1986), and 6-0HDA lesion of the nigrostriatal DA system (e.g., Steiner et al, 1988;Fornaguera et al, 1993Fornaguera et al, , 1994Sullivan et al, 1993). Thus, scanning can also serve as a useful and sensitive indicator of functional asymmetry.…”

“…Here, an asymmetry for the intact side is observed acutely after vibrissae removal, an asymmetry from which the animals can recover. These different behavioral states can then be used as a basis to study their relationships to possible changes in the brain, such as in the trigemino-thalamocortical system or in the basal ganglia (Huston et al, 1990;Adams et al, 1992). Finally, it should be pointed out that the analysis of scanning behavior may also be useful to indicate functional asymmetries in entirely intact animals (Schwarting et al, 1991b).…”

Efeito da remoção das vibrissas mistaciais sobre o comportamento exploratório do rato no labirinto em cruz elevado sob condições de claridade e obscuridade.

“…Essa morte de neurônios seria seguida por um processo de reorganização neuronial nos níveis superiores dessa via neural: complexo ventrobasal talámico, colículos superiores e córtex somatossensorial (Chiaia et al, 1992;Micheva e Beaulieu, 1995;Miyashita e Hamada, 1996). (Dun, 1959;Park, 1970;Woolsey e Van der Loos, 1970;Welker, 1971Welker, , 1976Van der Loos e Woolsey, 1973;Woolsey e Wann, 1976;Gustafson e Felbain-Keremidas, 1977;Arvidson e Johanson, 1980;Foerster, 1982;Ahl, 1986;Huston, et al, , 1988Steiner, et al, , 1992Symons e Tees, 1990;Barneóud, et al, 1991;Johansson e Arvidsson, 1991;Adams, et al, 1992;Fox, 1992;Levin e Dunn-Meynell, 1993;Toldi, et al, 1994).…”