Behavioral and neuroendocrine consequences of disrupting a long-term monogamous social bond in aging prairie voles

Grippo, Angela J.; McNeal, Neal; Normann, Marigny C; Colburn, William J.; Dagner, Ashley; Woodbury, Matthew

doi:10.1080/10253890.2020.1812058

Cited by 13 publications

(5 citation statements)

References 57 publications

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“…It should be noted however, that the microbiome of the offspring of these rats was largely preserved. Valproic acid has been linked to ASD in other animal models including mice and prairie voles (Ornoy et al, 2019;Sailer et al, 2019).…”

Section: Non-genetic Zebrafish Models Of Asd Valproic Acidmentioning

confidence: 99%

Using Zebrafish to Model Autism Spectrum Disorder: A Comparison of ASD Risk Genes Between Zebrafish and Their Mammalian Counterparts

Rea

Raay

2020

Front. Mol. Neurosci.

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Autism spectrum disorders (ASDs) are a highly variable and complex set of neurological disorders that alter neurodevelopment and cognitive function, which usually presents with social and learning impairments accompanied with other comorbid symptoms like hypersensitivity or hyposensitivity, or repetitive behaviors. Autism can be caused by genetic and/or environmental factors and unraveling the etiology of ASD has proven challenging, especially given that different genetic mutations can cause both similar and different phenotypes that all fall within the autism spectrum. Furthermore, the list of ASD risk genes is ever increasing making it difficult to synthesize a common theme. The use of rodent models to enhance ASD research is invaluable and is beginning to unravel the underlying molecular mechanisms of this disease. Recently, zebrafish have been recognized as a useful model of neurodevelopmental disorders with regards to genetics, pharmacology and behavior and one of the main foundations supporting autism research (SFARI) recently identified 12 ASD risk genes with validated zebrafish mutant models. Here, we describe what is known about those 12 ASD risk genes in human, mice and zebrafish to better facilitate this research. We also describe several non-genetic models including pharmacological and gnotobiotic models that are used in zebrafish to study ASD.

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Section: Non-genetic Zebrafish Models Of Asd Valproic Acidmentioning

confidence: 99%

Using Zebrafish to Model Autism Spectrum Disorder: A Comparison of ASD Risk Genes Between Zebrafish and Their Mammalian Counterparts

Rea

Raay

2020

Front. Mol. Neurosci.

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“…Here, we will focus on two pair-bonding species that have been well studied in the wild and in the laboratory, prairie voles (Microtus ochrogaster) and coppery titi monkeys (Plecturocebus cupreus). These species share the characteristics described above for human pair bonding, including preference for a specific partner [82][83][84][85], separation distress [47,51] and stress buffering by the partner [49,[86][87][88][89]. They both show behaviours that are sometimes associated with pair bonding in humans and other species, such as biparental care [90,91] and behavioural synchrony [92].…”

Section: Animal Models Of Partner Lossmentioning

confidence: 87%

Interactions between theκopioid system, corticotropin-releasing hormone and oxytocin in partner loss

Bales

Rogers

2022

Phil. Trans. R. Soc. B

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Selective adult social attachments, or ‘pair bonds’, represent central relationships for individuals in a number of social species, including humans. Loss of a pair mate has emotional consequences that may or may not diminish over time, and that often translate into impaired psychological and physical health. In this paper, we review the literature on the neuroendocrine mechanisms for the emotional consequences of partner loss, with a special focus on hypothesized interactions between oxytocin, corticotropin-releasing hormone and the κ opioid system. This article is part of the theme issue ‘Interplays between oxytocin and other neuromodulators in shaping complex social behaviours’.

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“…Such social challenges that older adults face include losing a partner, reduced engagement in social activities due to limited mobility or poor health, and being confronted with their own or their partner's increasing frailty (Dykstra et al, 2005). Additionally, the length of time spent in a relationship and age at which a partner is lost are both positively correlated with stress-related hormone release during isolation in prairie voles (Grippo et al, 2021). Thus, aging is related to increased social experience, and therefore, increased susceptibility to negative outcomes when either the relationship itself, or one's ability to actively participate in such relationships are lost.…”

Section: Social Connectedness Is Rewarding and Stress Buffering In So...mentioning

confidence: 99%

Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives

Vitale

Smith

2022

Front. Behav. Neurosci.

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In social species such as humans, non-human primates, and even many rodent species, social interaction and the maintenance of social bonds are necessary for mental and physical health and wellbeing. In humans, perceived isolation, or loneliness, is not only characterized by physical isolation from peers or loved ones, but also involves negative perceptions about social interactions and connectedness that reinforce the feelings of isolation and anxiety. As a complex behavioral state, it is no surprise that loneliness and isolation are associated with dysfunction within the ventral striatum and the limbic system – brain regions that regulate motivation and stress responsiveness, respectively. Accompanying these neural changes are physiological symptoms such as increased plasma and urinary cortisol levels and an increase in stress responsivity. Although studies using animal models are not perfectly analogous to the uniquely human state of loneliness, studies on the effects of social isolation in animals have observed similar physiological symptoms such as increased corticosterone, the rodent analog to human cortisol, and also display altered motivation, increased stress responsiveness, and dysregulation of the mesocortical dopamine and limbic systems. This review will discuss behavioral and neuropsychological components of loneliness in humans, social isolation in rodent models, and the neurochemical regulators of these behavioral phenotypes with a neuroanatomical focus on the corticostriatal and limbic systems. We will also discuss social loss as a unique form of social isolation, and the consequences of bond disruption on stress-related behavior and neurophysiology.

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Behavioral and neuroendocrine consequences of disrupting a long-term monogamous social bond in aging prairie voles

Cited by 13 publications

References 57 publications

Using Zebrafish to Model Autism Spectrum Disorder: A Comparison of ASD Risk Genes Between Zebrafish and Their Mammalian Counterparts

Using Zebrafish to Model Autism Spectrum Disorder: A Comparison of ASD Risk Genes Between Zebrafish and Their Mammalian Counterparts

Interactions between theκopioid system, corticotropin-releasing hormone and oxytocin in partner loss

Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives

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