“…Across the history of research on personality patterns and disease processes, it has been easier to demonstrate probable linkages between human behavior and specific physiological outcomes than to directly confirm a causal link between personality and disease. Thus, there have been plausible observations of the relationship of anxiety and anger to gastric secretions and hence possibly indirectly to ulcers (Kehoe & Ironside, 1963;Mittelman & Wolff, 1942;Wolf & Wolff, 1943), of stress to prolonged blood-pressure increase and hence possibly indirectly to essential hypertension (Andren, Hansson, Bjorkman, & Jonsson, 1980;Cohen, Evans, Krantz, & Stokols, 1980;D'Atri, Fitzgerald, Kasl, & Ostfeld, 1981;Evans, 1975;Light, 1981;Shapiro & Goldstein, 1982), and of hostility and challenge to autonomic reactivity and hence indirectly to cardiovascular disease (Glass et al, 1980;Krantz & Manuck, 1984;Matthews, 1982;Williams & Anderson, 1987;Wright, Contrada, & Glass, 1985).…”