Behavioral and physiological effects of oxidative stress throughout the lifecycle of Drosophila sod1 mutants

Woods, Scott

doi:10.17077/etd.njcb94yp

Cited by 2 publications

(3 citation statements)

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“…The mutant population undergoes a progressive selection over time in favor of healthier individuals while those with poor circuit performance die off earlier. Consistent with this view, Sod mutants reportedly have difficulty eclosing from their pupal case (Sahin et al, 2017;Woods, 2017) and the Sod lifespan curve lacks the earlier plateau phase ( Figure 1B) resulting from much higher mortality in young individuals compared to WT populations.…”

Section: °Csupporting

confidence: 62%

Distinct aging-vulnerable trajectories of motor circuit functions in oxidation- and temperature-stressedDrosophila

Iyengar

Ruan

2020

Preprint

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We examined several sensory-motor processing circuits in Drosophila across the lifespan and uncovered distinctive age-resilient and age-vulnerable trajectories in their established functional properties. We observed relatively little deterioration toward the end of lifespan in the giant-fiber (GF) and downstream circuit elements responsible for the jump-and-flight escape reflex. In contrast, we found substantial age-dependent modifications in the performance of GF inputs and other circuits driving flight motoneuron activities. Importantly, in high temperature (HT)-reared flies (29 °C), the characteristic age-dependent progression of these properties was largely maintained, albeit over a compressed time scale, lending support for the common practice of expediting Drosophila aging studies by HT rearing. We discovered shortened lifespans in Cu2+/Zn2+ Superoxide Dismutase 1 (Sod) mutant flies were accompanied by alterations distinct from HT-reared flies, highlighting differential effects of oxidative vs temperature stressors. This work also establishes several age-vulnerable parameters that may serve as quantitative neurophysiological landmarks for aging in Drosophila.

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Section: °Csupporting

confidence: 62%

Distinct aging-vulnerable trajectories of motor circuit functions in oxidation- and temperature-stressedDrosophila

Iyengar

Ruan

2020

Preprint

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“…Therefore, the Sod mutant population undergoes a progressive selection over time in favor of healthier individuals, while those with poor circuit performance die off earlier. Consistent with this view, Sod mutants reportedly have difficulty eclosing from their pupal case ( Phillips et al, 1989 ; Şahin et al, 2017 ; Woods, 2017 ) and the Sod life-span curve lacks the earlier plateau phase ( Fig. 1 B ) resulting from much higher mortality in young individuals compared with WT populations.…”

Section: Discussionsupporting

confidence: 60%

“…Therefore, the Sod mutant population undergoes a progressive selection over time in favor of healthier individuals while those with poor circuit performance die off earlier. Consistent with this view, Sod mutants reportedly have difficulty eclosing from their pupal case (Phillips et al, 1989;Şahin et al, 2017;Woods, 2017) and the Sod lifespan curve lacks the earlier plateau phase (Figure 1B) resulting from much higher mortality in young individuals compared to WT populations. This possibility is further highlighted in a recent study demonstrating certain differences in functional consequences of oxidative stress imposed chronically throughout development in mutant flies and those resulting from acute induction by drug feeding to healthy flies.…”

Section: Distinctive Patterns Of Aging-related Changes By High Temperature and Oxidative Stresssupporting

confidence: 62%

Distinct Aging-Vulnerable and -Resilient Trajectories of Specific Motor Circuit Functions in Oxidation- and Temperature-StressedDrosophila

Iyengar

Ruan

2021

eNeuro

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In Drosophila, molecular pathways affecting longevity have been extensively studied. However, corresponding neurophysiological changes underlying aging-related functional and behavioral deteriorations remain to be fully explored. We examined different pattern generator, interneuron inputs to the giant-fiber system, and circuits generating seizure discharge patterns. Notably, high-temperature rearing generally compressed aging trajectories while Sod mutation-induced oxidative stress led to distinct patterns of motor defects. Together, these results elucidate potentially salient neurophysiological markers for aging in flies.

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Behavioral and physiological effects of oxidative stress throughout the lifecycle of Drosophila sod1 mutants

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Cited by 2 publications

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Distinct aging-vulnerable trajectories of motor circuit functions in oxidation- and temperature-stressedDrosophila

Distinct aging-vulnerable trajectories of motor circuit functions in oxidation- and temperature-stressedDrosophila

Distinct Aging-Vulnerable and -Resilient Trajectories of Specific Motor Circuit Functions in Oxidation- and Temperature-StressedDrosophila

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