Behavioral and Psychological Issues in Long-Duration Head-Down Bed Rest

Seaton, Kimberly A.; Bowie, Kendra E.; Sipes, Walter A.

doi:10.3357/asem.br08.2009

Cited by 9 publications

(6 citation statements)

References 10 publications

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“…Moreover, the ground-based models used in researches simulated mostly only one or two of the environmental factors, such as microgravity (Seaton et al, 2009), isolation and confinement (Basner et al, 2014), or noise (Cheng et al, 2011), which differ greatly from the real spaceflight environment. To the best of our knowledge, only a few attempts have been made to study the influence of a simulated complex spaceflight environment on cognitive function (Ma et al, 2013; Shtemberg et al, 2014), and no comprehensive studies involving complex factors have yet been performed.…”

Section: Introductionmentioning

confidence: 99%

Dammarane Sapogenins Ameliorates Neurocognitive Functional Impairment Induced by Simulated Long-Duration Spaceflight

Dong

Liu

et al. 2017

Front. Pharmacol.

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Increasing evidence indicates the occurrence of cognitive impairment in astronauts under spaceflight compound conditions, but the underlying mechanisms and countermeasures need to be explored. In this study, we found that learning and memory abilities were significantly reduced in rats under a simulated long-duration spaceflight environment (SLSE), which includes microgravity, isolation confinement, noises, and altered circadian rhythms. Dammarane sapogenins (DS), alkaline hydrolyzed products of ginsenosides, can enhance cognition function by regulating brain neurotransmitter levels and inhibiting SLSE-induced neuronal injury. Bioinformatics combined with experimental verification identified that the PI3K-Akt-mTOR pathway was inhibited and the MAPK pathway was activated during SLSE-induced cognition dysfunction, whereas DS substantially ameliorated the changes in brain. These findings defined the characteristics of SLSE-induced cognitive decline and the mechanisms by which DS improves it. The results provide an effective candidate for improving cognitive function in spaceflight missions.

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Section: Introductionmentioning

confidence: 99%

Dammarane Sapogenins Ameliorates Neurocognitive Functional Impairment Induced by Simulated Long-Duration Spaceflight

Dong

Liu

et al. 2017

Front. Pharmacol.

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“…Currently, researchers have directed increasing attention to psychological issues. For example, numerous studies have investigated whether cognitive functions are affected during bed rest (Shehab et al, 1998; Dolenc et al, 2008; Lipnicki and Gunga, 2009; Lipnicki et al, 2009a; Seaton et al, 2009a,b; Jiang et al, 2013). Evidence for a detrimental effect of bed rest on executive functioning has been reported (Lipnicki et al, 2009a).…”

Section: Introductionmentioning

confidence: 99%

Decreasing ventromedial prefrontal cortex deactivation in risky decision making after simulated microgravity: effects of âˆ’6Â° head-down tilt bed rest

Rao

Zhou

Liang

et al. 2014

Front. Behav. Neurosci.

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Space is characterized by risk and uncertainty. As humans play an important role in long-duration space missions, the ability to make risky decisions effectively is important for astronauts who spend extended time periods in space. The present study used the Balloon Analog Risk Task to conduct both behavioral and fMRI experiments to evaluate the effects of simulated microgravity on individuals' risk-taking behavior and the neural basis of the effect. The results showed that participants' risk-taking behavior was not affected by bed rest. However, we found that the ventromedial prefrontal cortex (VMPFC) showed less deactivation after bed rest and that the VMPFC activation in the active choice condition showed no significant difference between the win outcome and the loss outcome after bed rest, although its activation was significantly greater in the win outcome than in the loss outcome before bed rest. These results suggested that the participants showed a decreased level of value calculation after the bed rest. Our findings can contribute to a better understanding of the effect of microgravity on individual higher-level cognitive functioning.

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“…Subjects were also assessed for roommate compatibility. Details can be found in the behavioral and psychological issues paper by Seaton et al within this supplement ( 8 ). From approximately 1200 initial phone interviews, 8 men and 5 women were entered into this study.…”

Section: A3mentioning

confidence: 99%

Long-Duration Head-Down Bed Rest: Project Overview, Vital Signs, and Fluid Balance

Meck¹,

Dreyer²,

Warren³

2009

aviat space environ med

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The following reports describe multi-disciplinary results from the standard measurements by which the responses to bed rest will be assessed and by which countermeasures will be evaluated. The data presented in this overview are meant to serve as a context in which to view the data presented in the discipline specific manuscripts. The dietary support and behavioral health papers provide additional information regarding those aspects of implementing bed rest studies successfully.

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Behavioral and Psychological Issues in Long-Duration Head-Down Bed Rest

Abstract: INTRODUCTION:Behavioral health services, similar to those offered to the U.S.

Cited by 9 publications

References 10 publications

Dammarane Sapogenins Ameliorates Neurocognitive Functional Impairment Induced by Simulated Long-Duration Spaceflight

Dammarane Sapogenins Ameliorates Neurocognitive Functional Impairment Induced by Simulated Long-Duration Spaceflight

Decreasing ventromedial prefrontal cortex deactivation in risky decision making after simulated microgravity: effects of âˆ’6Â° head-down tilt bed rest

Long-Duration Head-Down Bed Rest: Project Overview, Vital Signs, and Fluid Balance

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