Background: Depression and anxiety are prevalent global mental health conditions. In the 21st century, mental well-being and physical and social health are increasingly vital. Due to the intense competition in the profession, medical students may experience stress and depression due to the pressure to perform well academically. These symptoms can impact their academic progress, future medical practice, and patient care abilities. Objectives: The research investigates the prevalence of depressive symptoms among medical students at TSMU. It also aims to find causative factors that influence the onset of these symptoms, such as the period before an important exam, time spent away from family, or how mood changes impact their GPA. Furthermore, the study aims to identify gender-based disparities in symptom prevalence among participants. Methods: This study is a cross-sectional survey using a questionnaire. The prevalence of depressive symptoms among medical students at TSMU and their causative factors were assessed using a modified Patient Health Questionnaire-9 (PHQ-9). Results: In the study, 182 out of 195 participating medical students (93.33%) reported experiencing depressive symptoms. Notably, more female students (63.07%) exhibited these symptoms than male students (30%). The chi-square test results indicated no significant correlation between depressive symptoms and changes in symptom frequency before exams or the duration of time spent away from family and loved ones. Conclusions: Our study highlights the widespread occurrence of depressive symptoms in TSMU medical students. Implementing counseling services and interventions to enhance the academic environment may effectively reduce these symptoms. Further research is needed to determine the most effective interventions for addressing depression among medical students.