an article suggesting treatment recommendations for adult nightmare disorder. Although we appreciate the work by the authors, we were left with three basic concerns about the methodology utilized and results found. First, works providing evidence for some of the treatments were not reported in the original article. Second, search methodology in the original article was not used consistently at updated time points. Third, the original article only utilized results obtained from PubMed and did not consider other databases. The current study sought to replicate the methodology and compare fi ndings as well as expand by equalizing search methodology across updated time points. The present study expands the original efforts further by conducting article searches again on PsycINFO. Consequent changes to evidence levels and recommendations are discussed. Keywords: Nightmare disorder, nightmares, prazosin, Levomepromazine, Nabilone, cognitive behavioral therapy, imagery rehearsal therapy, exposure relaxation, rescripting therapy, psychotherapy Citation: Cranston CC; Davis JL; Rhudy JL; Favorite TK. Replication and expansion of "best practice guide for the treatment of nightmare disorder in adults". J Clin Sleep Med 2011;7 (5) 1 As researchers in this area, we read the guidelines with interest. Although we appreciate the work by the authors, we were left with three basic concerns about the methodology utilized and results found. First, we noted that a 2007 randomized clinical trial of one of the nightmare treatments was not included in the list of peer-reviewed scientifi c papers and thus not considered in determining recommendations for nightmare disorder treatment options. We were immediately aware of this omission as it was co-authored by one of the current authors [JLD] and wondered if other works were likewise missed. Second, it was unclear why the most recent search, conducted in February of 2010, did not include the original search terms (Table 1), but only "anxiety dreams." As the treatment of nightmares is a rapidly growing area of scientifi c interest, we wondered if treatment studies were missed by not including all relevant search terms in the most recent search. Third, we were surprised to read that the authors opted to not include in their search of the literature an exploration of databases other than PubMed, including PsycLit (the American Psychological Association integrated PsycLIT into PsycINFO in 2000 2 ), because "it was felt that these databases would not include clinically relevant material."1 Contrary to this opinion, in addition to PubMed (PM), PsycINFO (PI) is the most commonly used database for identifying medical and psychological literature, 3 such as systematic reviews, meta-analyses, and other clinically relevant research. Although there is some overlap between the two databases, PI provides further, unique results over and above PM, and indexes 73% of the top-tier psychiatric journals, compared to 47% in PM. 4 We determined to replicate and expand on the work of Aurora and colleagues in o...