Behavioral, cardiovascular and endocrine alterations induced by chronic stress in rats fed a high-fat diet

Batschauer, Tiago; Cordeiro, J. M.; Simas, Bruna B.; Brunetta, Henver Simionato; Souza, Raul Marin de; Nunes, Everson Araújo; Reis, Wagner Luis; Moreira, Eduardo Luiz Gasnhar; Crestani, Carlos C.; Santos, Adair Roberto Soares; Speretta, Guilherme Fleury Fina

doi:10.1016/j.physbeh.2020.113013

Cited by 6 publications

(4 citation statements)

References 48 publications

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“…The high-sugar diet is associated with an increased consumption of simple sugars, typically in the form of sucrose-or fructose-derived sweeteners. Several studies (81)(82)(83)(84)(85)(86)(87)(88)(89) have used a high-sugar diet (or 'high-sugar and high-fat' or 'Western diet') to intervene in rodents and observed the effects of anxiety/depression-like behaviour (also shown in Table 1). There is a study that has particularly attracted attention; male BALBc mice (an inbred immune-deficient mouse) were fed a high-sugar diet (60 % sugar) for 9 weeks, with a significant increase in body weight and total cholesterol, and the mice showed anxiety-like behaviour abnormalities.…”

Section: Dietary Fat Contentmentioning

confidence: 99%

Dietary and metabolic risk of neuropsychiatric disorders: insights from animal models

et al. 2021

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Neuropsychiatric disorders are major causes of the global burden of diseases, frequently co-occurring with multiple comorbidities, especially obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease and its various risk factors in metabolic syndrome. While the determining factors of neuropsychiatric disorders are complex, recent studies have shown that there is a strong link between diet, metabolic state and neuropsychiatric disorders, including anxiety and depression. There is no doubt that rodent models are of great value for preclinical research. Therefore, this article focuses on a rodent model of chronic consumption of high-fat diet (HFD), and/or the addition of a certain amount of cholesterol or sugar. Meanwhile, summarizes the pattern of diet that induces anxiety/depressive-like behaviour and the underlying mechanism. We highlight how dietary and metabolic risk influence neuropsychiatric behaviour in animals. Changes in dietary patterns, especially HFD, can induce anxiety or depression-like behaviours, which may vary by diet exposure period, sex, age, species, and genetic background of the animals used. Furthermore, dietary patterns significantly aggravate anxiety/depression-like behaviour in animal models of neuropsychiatric disorders. The mechanisms by which diet induces anxiety/depressive-like behaviour may involve neuroinflammation, neurotransmitters/neuromodulators, neurotrophins, and the gut-brain axis. Future research should be focused on elucidating the mechanism and identifying the contribution of diet and diet-induced metabolic risk to neuropsychiatric disorders, which can form the basis for future clinical dietary intervention strategies for neuropsychiatric disorders.

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Section: Dietary Fat Contentmentioning

confidence: 99%

Dietary and metabolic risk of neuropsychiatric disorders: insights from animal models

et al. 2021

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“…In our study, we aimed to determine whether unpredictable stress affects specific long-chain ceramide concentrations or alters the effects of HFD on serum ceramides in male and female rats. To avoid ceiling effects and increase the probability of identifying synergistic effects, we chose to combine modest duration HFD with 4 days of unpredictable stress (STU stress) which is below the 7–10 days of unpredictable stress needed to induce depressive-like phenotypes in rodents ( Zurita et al, 2000 ; Maslova et al, 2002 ; Batschauer et al, 2020 ; Meng et al, 2020 ; Fang et al, 2021 ). We found that although exposing male and female rats to HFD and/or STU stress increased certain peripheral long-chain ceramide levels, the increases did not correlate with changes in anhedonia-like behavior or behavioral despair.…”

Section: Introductionmentioning

confidence: 99%

High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair

Sambolín-Escobales

Tirado-Castro

Suárez

et al. 2022

Front. Mol. Biosci.

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Clinical and preclinical studies suggest that increases in long-chain ceramides in blood may contribute to the development of depressive-like behavior. However, which factors contribute to these increases and whether the increases are sufficient to induce depressive-like behaviors is unclear. To begin to address this issue, we examined the effects of high fat diet (HFD) and short-term unpredictable (STU) stress on long-chain ceramides in the serum of male and female rats. We found that brief exposure to HFD or unpredictable stress was sufficient to induce selective increases in the serum concentrations of long-chain ceramides, associated with depression in people. Furthermore, combined exposure to HFD and unpredictable stress caused a synergistic increase in C16:0, C16:1, and C18:0 ceramides in both sexes and C18:1 and C24:1 in males. However, the increased peripheral long-chain ceramides were not associated with increases in depressive-like behaviors suggesting that increases in serum long-chain ceramides may not be associated with the development of depressive-like behaviors in rodents.

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“…The chronic variable stress (CVS) model involves presenting a rodent to a variety of stressors (e.g., restraint, cold stress, social stress) in a randomized order to mimic unpredictable and uncontrollable living challenges (Fuchs & Fliugge, 2006; Iñiguez, Vialou, et al., 2010). Specifically, exposure to stress alters intake of food and palatable fluids (Batschauer et al., 2020; Gharibeh et al., 2022; Martí et al., 1994; Tamashiro et al., 2004; Zylan & Brown, 1996), and thus, it is possible that long‐term molecular and behavioral changes induced by early‐life FLX exposure may alter responses to food following CVS.…”

Section: Introductionmentioning

confidence: 99%

Acute and long‐lasting effects of adolescent fluoxetine exposure on feeding behavior in Sprague–Dawley rats

Castro

Frankot

Moran

et al. 2022

Developmental Psychobiology

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The antidepressant medication fluoxetine (FLX) is frequently prescribed for the management of mood-related illnesses in the adolescent population-yet its long-term neurobehavioral consequences are not understood. To investigate how juvenile FLX exposure influences feeding behavior in adulthood, we conducted two experiments. In Experiment 1, adolescent male and female Sprague-Dawley rats were administered with 20 mg/kg/day FLX (postnatal day [PND] 35-49) and exposed to a binge access paradigm in adulthood (PND72+) to evaluate potential alterations for sweetened-fat preference. No long-term FLX-induced differences in preference for sweetened fat versus chow, nor total caloric intake, were noted; however, females displayed higher preference for sweetened fat compared to males. In Experiment 2, PND35 male rats received FLX (PND35-49) and were exposed to chronic variable stress (CVS) in adulthood (PND74-88). During treatment, FLX decreased body weight and intake (meal size), but not total meal number. Also, no differences in meal pattern parameters were observed after FLX completion. Likewise, no differences in meal pattern parameters to a palatable diet (45% fat, 17% sucrose) presented from PND74 to PND88, even after CVS, were observed. Our findings indicate that juvenile FLX reduces body weight gain acutely via reduced meal size intake; however, no long-term changes in ad libitum feeding behavior or binge access to a palatable stimulus are evident.

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Behavioral, cardiovascular and endocrine alterations induced by chronic stress in rats fed a high-fat diet

Cited by 6 publications

References 48 publications

Dietary and metabolic risk of neuropsychiatric disorders: insights from animal models

Dietary and metabolic risk of neuropsychiatric disorders: insights from animal models

High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair

Acute and long‐lasting effects of adolescent fluoxetine exposure on feeding behavior in Sprague–Dawley rats

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