Behavioral changes in developing mice after prenatal exposure to paroxetine (Paxil)

Coleman, F. Holly; Christensen, H.Dix; Gonzalez, Christina L.; Rayburn, William F.

doi:10.1016/s0002-9378(99)70102-x

Cited by 46 publications

(45 citation statements)

References 8 publications

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“…A similar finding was reported with prenatal bupropion exposure (Su et al, 2007). In contrast, Coleman et al (1999) and Stewart et al (1998) observed no changes in baseline locomotion or quinpirole-induced stereotypy attributable to prenatal SSRI exposure.…”

Section: H Behavioral Outcomesmentioning

confidence: 69%

“…Others have reported increased immobility in the forced swim test for females in adolescence and adulthood (Lisboa et al, 2007). However, others report no differences in anxiety-or depressive-like behaviors (Coleman et al, 1999;Hsiao et al, 2005;Lisboa et al, 2007;Favaro et al, 2008). Ultrasonic vocalizations during separation or behavioral testing were increased in pups prenatally exposed to fluoxetine or paroxetine (Coleman et al, 1999;Cagiano et al, 2008).…”

Section: H Behavioral Outcomesmentioning

confidence: 99%

“…However, others report no differences in anxiety-or depressive-like behaviors (Coleman et al, 1999;Hsiao et al, 2005;Lisboa et al, 2007;Favaro et al, 2008). Ultrasonic vocalizations during separation or behavioral testing were increased in pups prenatally exposed to fluoxetine or paroxetine (Coleman et al, 1999;Cagiano et al, 2008). Prenatal exposure to the atypical antidepressant bupropion produced a decrease in rearing and ambulatory activity in the open-field test in adult male mice, although the doses used have not been commented upon as clinically relevant (Hsiao et al, 2005;Su et al, 2007).…”

Section: H Behavioral Outcomesmentioning

confidence: 99%

“…Prenatal fluoxetine exposure produced impaired sexual motivation in adult mice measured by no difference in preference for social contact with a male versus a female (Gouvêa et al, 2008). Aggressive behavior and foot shock-induced aggressive behavior have been shown to increase following prenatal SSRI exposure (Singh et al, 1998;Coleman et al, 1999). Several studies report no changes in social interaction or sexual behavior (Lisboa et al, 2007;Cagiano et al, 2008).…”

Section: H Behavioral Outcomesmentioning

confidence: 99%

See 3 more Smart Citations

Prenatal Antidepressant Exposure: Clinical and Preclinical Findings

2014

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Section: H Behavioral Outcomesmentioning

confidence: 69%

Section: H Behavioral Outcomesmentioning

confidence: 99%

Section: H Behavioral Outcomesmentioning

confidence: 99%

Section: H Behavioral Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

Prenatal Antidepressant Exposure: Clinical and Preclinical Findings

2014

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“…Several studies have attempted to categorize possible longitudinal effects of SRI exposure during this period (Vorhees et al, 1994;Cabrera-Vera et al, 1997;Cabrera-Vera and Battaglia, 1998;Coleman et al, 1999;Christensen et al, 2000;Rayburn et al, 2000;Morrison et al, 2004;Vartazarmian et al, 2005), but these studies are of limited clinical relevance for several reasons. With the exception of a single study (Vartazarmian et al, 2005), dams were dosed only once or twice daily during gestations.…”

Section: Discussionmentioning

confidence: 99%

Serotonin Transporter Occupancy in Rats Exposed to Serotonin Reuptake Inhibitors In Utero or via Breast Milk

Capello

Bourke

Ritchie

et al. 2011

J Pharmacol Exp Ther

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Rigorous data regarding fetal central nervous system (CNS) exposure after antidepressant exposure are sparse. The magnitude of serotonin reuptake inhibitor (SRI) CNS exposure was measured in three groups of rats using ex vivo autoradiography of the serotonin transporter (SERT): 1) in utero, 2) postnatal clearance after birth, and 3) exposure through lactation. Rats were exposed to one of five SRI-type antidepressants (escitalopram, fluoxetine, paroxetine, sertraline, and venlafaxine) administered continuously via osmotic minipumps to pregnant or nursing dams. Dam dosing was adjusted to reflect the 50th and 85th percentiles of serum concentrations observed in pregnant women. Embryonic day 21 rat pups exposed in utero exhibited Ͼ80% SERT occupancy in brain tissue, which is equivalent to that of the pregnant dam and similar to that reported for human pharmacotherapy. Venlafaxine was the exception with occupancies ranging from 61 to 92% across different litters. The magnitude of SERT occupancy is essentially equivalent between dams and fetuses. By postnatal day 4, high SERT occupancy was observed only in fluoxetine-exposed pups (41-92% occupancy). Significantly less, but measurable, exposure occurred via breast milk exposure even in the absence of detectable drug concentrations in nursing pup sera. Pups exposed to SRIs via breast milk for 3 or 7 days exhibited varying SERT occupancies (0 -57% depending on the individual medication and dam dose). These data highlight the need for animal modeling of fetal and nursing infant drug exposure using clinically meaningful dosing strategies and appropriate CNS measures to develop rational treatment guidelines that systematically minimize fetal and neonatal medication exposure in humans.

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Impulsivity, aggression, and serotonin: a molecular psychobiological perspective

Lesch

Merschdorf²

2000

Behav. Sci. Law

309

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The expression of aggressiveness, which constitutes many facets of behavior, is influenced by a complex interaction of biologic, psychologic, and social variables. Even though individual differences in impulsivity and the behavioral consequences, such as aggression, addiction, and suicidality, are substantially heritable, they ultimately result from an interplay between genetic variations and environmental factors. While formation and integration of multiple neural networks is dependent on the actions of neurotransmitters, such as serotonin (5HT), converging lines of evidence indicate that genetically determined variability in serotonergic gene expression influences complex traits including that of inappropriately aggressive behavior. This contribution reviews studies of major gene effects in inbred and knockout strains of mice with increased aggression-related behavior and discusses the relevance of several serotonergic gene variations in humans which include high aggressiveness as part of the phenotype. Although special emphasis is given to the molecular psychobiology of 5HT in aggression-related behavior in rodents, nonhuman primates, and humans, relevant conceptual and methodological issues in the search for candidate genes for impulsivity and aggressiveness and for the development of mouse models of aggressive and antisocial behavior in humans are also considered.

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Behavioral changes in developing mice after prenatal exposure to paroxetine (Paxil)

Cited by 46 publications

References 8 publications

Prenatal Antidepressant Exposure: Clinical and Preclinical Findings

Prenatal Antidepressant Exposure: Clinical and Preclinical Findings

Serotonin Transporter Occupancy in Rats Exposed to Serotonin Reuptake Inhibitors In Utero or via Breast Milk

Impulsivity, aggression, and serotonin: a molecular psychobiological perspective

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