Behavioral changes in male mice fed a high-fat diet are associated with IL-1β expression in specific brain regions

Almeida-Suhett, Camila P.; Graham, Alice M.; Chen, Yifan; Deuster, Patricia A.

doi:10.1016/j.physbeh.2016.11.016

Cited by 121 publications

(84 citation statements)

References 87 publications

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“…No significant genotype by diet interactions were observed in the expression of inflammation-related genes in the hippocampus. However, HFD was observed to increase IL-1β levels, which is in keeping with previous work (Almeida-Suhett et al, 2017). HFD also increased the expression of complement C4A, which brain 5-HT deficiency was shown to reduce.…”

Section: Discussionsupporting

confidence: 90%

“…Despite the high degree of comorbidity between obesity and affective disorders (Faith et al, 2002;Stunkard et al, 2003), the effects of obesity on depression-and anxiety-like behaviors remain debated. Several recent preclinical studies have reported that high-fat diet (HFD) can increase anxiety-and depression-like behaviors across a range of species, including nonhuman primates (Sullivan et al, 2010), mice (Sharma and Fulton, 2013;Strekalova et al, 2015;Almeida-Suhett et al, 2017;Bridgewater et al, 2017;Kurhe et al, 2017;Wu et al, 2018;Xu et al, 2018;Ogrodnik et al, 2019), and rats (Abildgaard et al, 2011;Aslani et al, 2015;Dutheil et al, 2016;Rebolledo-Solleiro et al, 2017;Alonso-Caraballo et al, 2019). However, multiple other reports have noted reductions in depression-and/or anxiety-like behavior following chronic consumption of HFD (Maniam and Morris, 2010a,b;Finger et al, 2011;Dornellas et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus

Karth

Baugher

Daly

et al. 2019

Front. Mol. Neurosci.

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Obesity is associated with an increased risk of depression and anxiety disorders, but the nature of the relationship(s) between obesity and mental illness remains highly controversial. Some argue that depression and anxiety lead to increased consumption of "comfort foods," the intake of which reduces negative affect and promotes obesity. In contrast, others have theorized that negative affect results from chronic excessive consumption of highly palatable foods. The brain serotonin (5-HT) system has long been implicated in both the development and treatment of mental illness. Preclinical studies have shown that low brain 5-HT exacerbates depression-and anxiety-like behaviors induced by stress and blocks reductions in depression-like behavior induced by antidepressants, but the effects of brain 5-HT deficiency on responses to high-fat diet (HFD) have not been explored. The current work used genetically modified mice to evaluate the effects of low 5-HT on behavioral and molecular alterations induced by chronic exposure to HFD. Our results reveal that HFD decreases depression-like behavior and increases some anxiety-like behaviors in wild-type (WT) mice. However, genetic brain 5-HT deficiency blocks HFD-induced reductions in forced swim immobility and prevents HFD-induced increases in hippocampal GSK3β phosphorylation despite having no significant effects on HFD-induced changes in body weight or anxiety-like behavior. Together, our results suggest that brain 5-HT deficiency significantly impacts a subset of behavioral and molecular responses to HFD, a finding that could help explain the complex relationships between obesity and mental illness.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus

Karth

Baugher

Daly

et al. 2019

Front. Mol. Neurosci.

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show abstract

“…46 Nonetheless, high-fat diet consumption has been demonstrated to impair hippocampus-dependent memory function in humans and rodents. For example, compared to rodents that consumed a control diet, those that consumed a high-fat and/or high-sugar diet exhibited robust impairments in various types of memory (e.g., spatial, contextual), as indicated by weaker performances in the Y-maze, 48 radial arm maze, 15 novel object recognition task, 15 novel place recognition task, 44,49 Morris water maze, 50 and contextual fear conditioning.…”

Section: Adult Consumption Of a High-fat Diet: A Vulnerability Factormentioning

confidence: 99%

“…52 Many of these studies, and others, have shown that high-fat diet-induced cognitive deteriorations are accompanied by elevated neuroinflammatory markers or responses in the hippocampus. 15,18,44,[48][49][50][51]53 However, the mechanisms by which these neuroinflammatory processes signal and/or affect the hippocampus are not entirely clear. There is growing evidence that high-fat diets may compromise the hippocampus by sensitizing the immune cells (most likely microglia) of this brain structure, thus priming the inflammatory response to subsequent challenging stimuli.…”

Section: Adult Consumption Of a High-fat Diet: A Vulnerability Factormentioning

confidence: 99%

Food for thought: how nutrition impacts cognition and emotion

et al. 2017

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More than one-third of American adults are obese and statistics are similar worldwide. Caloric intake and diet composition have large and lasting effects on cognition and emotion, especially during critical periods in development, but the neural mechanisms for these effects are not well understood. A clear understanding of the cognitive-emotional processes underpinning desires to over-consume foods can assist more effective prevention and treatments of obesity. This review addresses recent work linking dietary fat intake and omega-3 polyunsaturated fatty acid dietary imbalance with inflammation in developing, adult, and aged brains. Thus, early-life diet and exposure to stress can lead to cognitive dysfunction throughout life and there is potential for early nutritional interventions (e.g., with essential micronutrients) for preventing these deficits. Likewise, acute consumption of a high-fat diet primes the hippocampus to produce a potentiated neuroinflammatory response to a mild immune challenge, causing memory deficits. Low dietary intake of omega-3 polyunsaturated fatty acids can also contribute to depression through its effects on endocannabinoid and inflammatory pathways in specific brain regions leading to synaptic phagocytosis by microglia in the hippocampus, contributing to memory loss. However, encouragingly, consumption of fruits and vegetables high in polyphenolics can prevent and even reverse age-related cognitive deficits by lowering oxidative stress and inflammation. Understanding relationships between diet, cognition, and emotion is necessary to uncover mechanisms involved in and strategies to prevent or attenuate comorbid neurological conditions in obese individuals.

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“…Secondly, we aimed to investigate whether the reduction of PTP1B expression in the CeA of rats on HFD improves the anorexigenic effect of insulin and the energy expenditure ameliorating the obese phenotype. Obesity and high-fat feeding are associated with anxiety disorders [25][26][27]. In this regard, the amygdala was pointed out as an important area for the development of anxiety-like behavior in rodents on HFD [27].…”

Section: Introductionmentioning

confidence: 99%

Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior

et al. 2017

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show abstract

Behavioral changes in male mice fed a high-fat diet are associated with IL-1β expression in specific brain regions

Cited by 121 publications

References 87 publications

Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus

Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus

Food for thought: how nutrition impacts cognition and emotion

Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior

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