Behavioral correlates of plasma sex hormones and their relationships with plasma lipids and lipoproteins in Japanese men

Handa, Koichi

doi:10.1016/s0021-9150(96)06041-8

Cited by 34 publications

(36 citation statements)

References 31 publications

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“…Therefore, taking SHBG into account (either by adjustment of SHBG or by assessment using FT or Endogenous testosterone and lipid profile B-P Jiann et al BT) is critical to discern the effect of TT on TGs and HDL-C. When the confounding effect of SHBG was considered, insignificant correlation of TT and fasting TGs was reported in other studies, 6,10,22,23 which was compatible with our finding. The relationship of testosterone and postprandial TGs has been seldom addressed.…”

Section: Discussionsupporting

confidence: 90%

“…It is hypothesized that increased visceral fat, which is associated with low testosterone levels, 25 leads to overproduction of very low-density lipoprotein particles 26 and these particles compete with dietary TGs for the same clearance mechanism, and causes the elevation of postprandial TGs. 27 When the effect of SHBG was taken into account, divergent results were reported in the association between testosterone and HDL-C, with most reporting no association 6,20,23,28 and some reporting an inverse 10 or a positive association 29,30 between them. The inconsistency may come from methodological difference or from the true difference in the study populations.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies reported no correlation between them, 6,10,17,21,23,31 and several studies reported an unfavorable association of testosterone with TC, LDL-C and apoprotein B. 6,7,29 According to the evidences that every 1.0 mg dl À1 elevation in HDL-C levels and decrease in LDL-C levels may reduce the risk of cardiovascular disease by 2-4% 32 and 0.6%, 33 respectively, Endogenous testosterone and lipid profile B-P Jiann et al and the magnitudes of associations of testosterone with HDL-C and LDL-C shown in this study, the unfavorable effect of testosterone on LDL-C for cardiovascular system neutralizes the favorable effect of testosterone on HDL-C.…”

Section: Discussionmentioning

confidence: 99%

“…Most epidemiological studies demonstrated that endogenous testosterone levels were associated with plasma triglycerides (TGs) and HDL-C in a beneficial direction for the cardiovascular system. 3,4,8 But there were some different reports in Japanese men with one study reporting a positive correlation between free testosterone (FT) and TGs; 9 another one, a negative correlation between FT and HDL-C levels; 10 and the other two, no correlation between FT and HDL-C and TGs. 11,12 Studies in this aspect were scanty in other Asian men.…”

Section: Introductionmentioning

confidence: 99%

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Associations of endogenous testosterone and lipid profiles in middle-aged to older Taiwanese men

et al. 2011

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The relationship between endogenous plasma testosterone and plasma lipids was assessed among 856 Taiwanese men^40 years old originally recruited for an epidemiological study of testosterone deficiency syndrome. Blood samples were drawn from fasting (n ¼ 562) and non-fasting (n ¼ 294) subjects between 0800 to 1100 hours. With adjustment of age, body mass index and sex hormonebinding globulin, the following results were shown: (i) triglyceride (TG) levels were negatively associated with quartile levels of testosterone, and the magnitudes of associations were greater for postprandial TGs than for fasting TGs; (ii) high-density lipoprotein cholesterol (HDL-C) levels were positively related to quartile levels of testosterone, but the associations became insignificant after further control of TGs; and (iii) the calculated low-density lipoprotein cholesterol (LDL-C) levels were positively associated with quartile levels of testosterone. Similar results were obtained in multivariate linear regression analyses with additional control of hypertension and diabetes. In these Taiwanese men, the favorable association of endogenous plasma testosterone with HDL-C counterbalances the unfavorable association of it with LDL-C, while the net influence of testosterone on plasma lipids for cardiovascular system was still in the beneficial direction due to its negative association with postprandial plasma TG levels.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations of endogenous testosterone and lipid profiles in middle-aged to older Taiwanese men

et al. 2011

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“…A observação de alterações nas concentrações plasmáticas dos esteróides sexuais e proteína carreadora em indivíduos diabéticos (18,27) e suas associações com alterações no perfil lipídico e glicídico têm sido fonte para numerosos estudos (28,29). Os efeitos dos esteróides sexuais sobre o metabolismo lipídico podem ser evidenciados pelas diferenças entre os sexos nas concentrações de triglicerídeos, LDL e HDL, responsáveis, pelo menos em parte, pela diferença no risco de doença cardiovascular (30).…”

Section: Discussionunclassified

Interrelações entre SHBG e esteróides sexuais com medidas antropométricas, pressão arterial e lipídeos em mulheres com e sem diabetes mellitus tipo 2

Bahia

Dimetz

Gazolla

et al. 2000

Arq Bras Endocrinol Metab

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RESUMOCom o objetivo de analisar as concentrações plasmáticas de SHBG, dos esteróides sexuais, perfil glicídico, lipídico e suas relações com variáveis clínicas, demográficas e medidas antropométricas, estudamos um grupo de 80 mulheres na pós-menopausa, 40 com diabetes mellitus (DM) tipo 2, com idade de 64,9±7,1 anos e duração conhecida do diabetes de 13,4±1,4 anos e 40 não diabéticas com idade de ól±8,9 anos. Foram analisados: idade, índice de massa corporal (IMC), relação cinturaquadril (RCQ), cintura, pressão arterial sistólica (PAs) e diastólica (PAd). As mulheres diabéticas apresentaram maior freqüência de distribuição andróide de gordura (75% vs. 50%, p= 0,03), maior PAs (p= 0,01), maior testosterona total (p= 0,003), índice de testosterona livre (p= 0,002) e índice de resistência insulínica (IRI) (p= 0,000) do que as mulheres não diabéticas. As não diabéticas com distribuição andróide de gordura apresentaram menores níveis de SHBG do que aquelas com distribuição ginecóide (p= 0,008). No grupo com IMC ³30kg/m2 e no grupo com cintura ³88cm, as mulheres diabéticas apresentaram maior testosterona total e índice de testosterona livre do que as mulheres não diabéticas. As não diabéticas com distribuição andróide de gordura apresentaram maior índice de testosterona livre do que aquelas com distribuição ginecóide (p= 0,01). As diabéticas com distribuição andróide apresentaram maiores níveis de estradiol do que aquelas com distribuição ginecóide (p= 0,02). Em conclusão, mulheres diabéticas apresentaram maior freqüência de distribuição abdominal de gordura, estando associada à maiores concentrações de testosterona total, índice de testosterona livre e estradiol e menores concentrações de SHBG. ABSTRACTIn order to investigate the relationship between plasma leveis of SHBG, sex steroids and glucose metabolism, lipid profile, anthropometric measurements, clinical and demographic variables, we studied a group of 80 post-menopausal women, 40 with type 2 diabetes (DM2) aged 64.9±7.1 and with known DM duration of 13.4± 1.4 years and 40 non-diabetic aged 61 ±8.9. We analyzed: age, body mass index (BMI), waist to hip ratio (WHR), waist, systolic (sBP) and diastolic blood pressure (dBP). Diabetic women had higher frequency of android adiposity (75% vs. 50%, p= 0.03), higher sBP (p= 0.01), higher total testosterone (p= 0.003), free testosterone index (p= 0.02) and insulin resistance index (IRI) (p= 0.000) than non-diabetic women. Non-diabetics with android adiposity had lower levels of SHBG than those with ginecoid adiposity (p= 0.008). In the group with BMI ³30kg/m2 and in the group with waist ³88cm diabetic women had higher total testosterone and free testosterone index than non-dia-

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Smoking and Prostate Cancer Survival and Recurrence

Kenfield

Stampfer²,

Chan³

et al. 2011

JAMA

229

189

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Context Studies of smoking in relation to prostate cancer mortality or recurrence in prostate cancer patients are limited, with few prostate cancer-specific outcomes. Objective To assess the relation of cigarette smoking and smoking cessation with overall, prostate cancer-specific, and CVD mortality and biochemical recurrence among men with prostate cancer. Design, Setting, and Participants Prospective observational study of 5 366 men diagnosed with prostate cancer between 1986–2006 in the Health Professionals Follow-Up Study. Main Outcome Measures Hazard ratios (HRs) for overall, prostate cancer-specific, and CVD mortality, and biochemical recurrence, defined by PSA rise. Results We documented 1,630 deaths, 524 (32%) due to prostate cancer and 416 (26%) due to CVD, and 878 biochemical recurrences. The absolute crude rates for prostate cancer-specific death for never smokers vs. current smokers were 9.6 vs. 15.3 per 1,000 person-years; for all-cause mortality the corresponding rates were 27.3 and 53.0 per 1,000 person-years. In multivariable analysis, compared with never smokers, current smokers had an increased risk of prostate cancer mortality (HR, 1.61; 95% confidence interval [CI], 1.11–2.32 and among men with clinical stage T1–T3: HR, 1.80; 95% CI, 1.04–3.12), biochemical recurrence (HR, 1.61; 95% CI, 1.16–2.22), total mortality (HR, 2.28; 95% CI, 1.87–2.80), and CVD mortality (HR, 2.13; 95% CI, 1.39–3.26). After adjusting for clinical stage and grade which are likely intermediates of the relation of smoking with prostate cancer recurrence and survival, the estimates for current smoking were as follows: prostate cancer mortality (HR, 1.38; 95% CI, 0.94–2.03 and HR, 1.41; 95% CI, 0.80–2.49); biochemical recurrence (HR, 1.47; 95% CI, 1.06–2.04). A greater number of pack-years was associated with a significantly increased risk of prostate cancer mortality but not biochemical recurrence: for current smokers of 40+ pack-years compared to never smokers: prostate cancer mortality (HR, 1.82; 95% CI, 1.03–3.20; biochemical recurrence (HR, 1.48; 95% CI, 0.88–2.48). Compared to current smokers, those who had quit smoking for 10 or more years, or who had quit for less than 10 years but smoked less than 20 pack-years, had prostate cancer mortality risks similar to never smokers: former smoker, quit 10+ years (HR, 0.60; 95% CI, 0.42–0.87); quit <10 years and <20 pack-years (HR, 0.64; 95% CI, 0.28–1.45); never smoker (HR, 0.61; 95% CI, 0.42–0.88). Conclusions Smoking at the time of prostate cancer diagnosis is associated with increased overall and CVD mortality and prostate cancer-specific mortality and recurrence. 10-year quitters have prostate cancer-specific mortality risks similar to never smokers.

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Behavioral correlates of plasma sex hormones and their relationships with plasma lipids and lipoproteins in Japanese men

Cited by 34 publications

References 31 publications

Associations of endogenous testosterone and lipid profiles in middle-aged to older Taiwanese men

Associations of endogenous testosterone and lipid profiles in middle-aged to older Taiwanese men

Interrelações entre SHBG e esteróides sexuais com medidas antropométricas, pressão arterial e lipídeos em mulheres com e sem diabetes mellitus tipo 2

Smoking and Prostate Cancer Survival and Recurrence

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