Behavioral Dermatopathies in Small Mammals

Tynes, Valarie V.

doi:10.1016/j.cvex.2013.05.004

Cited by 15 publications

(15 citation statements)

References 49 publications

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“…However, several trends were observed: the number of both the total revolutions and clockwise revolutions was increased in the 129SVE knockout animals, perseveration in the Y-maze was observed in FVB heterozygous mice and an increase in grooming was found for Shank3 -deficient mice of both the 129SVE and C57 strains. Barbering is an abnormal repetitive behavior, which is analogous to human compulsive hair pulling, that is commonly observed in some strains of mice such as C57- and 129SVE-derived strains (Sarna et al, 2000; Kurien et al, 2005; Kalueff et al, 2006; Kalueff et al, 2007; Tynes, 2013). In the present study, barbering was observed in 66% of the 129SVE animals, but only in two mice of the C57 strain and none of the FVB animals.…”

Section: Discussionmentioning

confidence: 99%

Absence of strong strain effects in behavioral analyses ofShank3-deficient mice

Drapeau

Dorr

Elder

et al. 2014

Disease Models &Amp; Mechanisms

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Haploinsufficiency of SHANK3, caused by chromosomal abnormalities or mutations that disrupt one copy of the gene, leads to a neurodevelopmental syndrome called Phelan-McDermid syndrome, symptoms of which can include absent or delayed speech, intellectual disability, neurological changes and autism spectrum disorders. The SHANK3 protein forms a key structural part of the post-synaptic density. We previously generated and characterized mice with a targeted disruption of Shank3 in which exons coding for the ankyrin-repeat domain were deleted and expression of full-length Shank3 was disrupted. We documented specific deficits in synaptic function and plasticity, along with reduced reciprocal social interactions, in Shank3 heterozygous mice. Changes in phenotype owing to a mutation at a single locus are quite frequently modulated by other loci, most dramatically when the entire genetic background is changed. In mice, each strain of laboratory mouse represents a distinct genetic background and alterations in phenotype owing to gene knockout or transgenesis are frequently different across strains, which can lead to the identification of important modifier loci. We have investigated the effect of genetic background on phenotypes of Shank3 heterozygous, knockout and wild-type mice, using C57BL/6, 129SVE and FVB/Ntac strain backgrounds. We focused on observable behaviors with the goal of carrying out subsequent analyses to identify modifier loci. Surprisingly, there were very modest strain effects over a large battery of analyses. These results indicate that behavioral phenotypes associated with Shank3 haploinsufficiency are largely strain-independent.

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Section: Discussionmentioning

confidence: 99%

Absence of strong strain effects in behavioral analyses ofShank3-deficient mice

Drapeau

Dorr

Elder

et al. 2014

Disease Models &Amp; Mechanisms

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“…Behavioural dermatopathies (Tynes, 2013) are relevant in some farms, particularly barbering within litters or with neighbours. Lastly, skin disorders such as inherited alopecia might rarely be observed in young rabbits.…”

Section: Skin Disorders (Other Than Pododermatitis or Skin Lesions)mentioning

confidence: 99%

Health and welfare of rabbits farmed in different production systems

Nielsen

Álvarez²,

Bicout³

et al. 2020

EFS2

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The AGRI committee of the European Parliament requested EFSA to assess the welfare of rabbits farmed in different production systems, including organic production, and to update its 2005 scientific opinion about the health and welfare of rabbits kept for meat production. Considering reproducing does, kits and growing rabbits, this scientific opinion focusses on six different housing systems, namely conventional cages, structurally enriched cages, elevated pens, floor pens, outdoor/partially outdoor systems and organic systems. To compare the level of welfare in the different housing systems and rabbit categories, welfare impact scores for 20 welfare consequences identified from the literature were calculated, taking their occurrence, duration and severity into account. Based on the overall welfare impact score (sum of scores for the single welfare consequences), obtained via a 2-step expert knowledge elicitation process, the welfare of reproducing does is likely (certainty 66-90%) to be lower in conventional cages compared to the five other housing systems. In addition, it is likely to extremely likely (certainty 66-99%) that the welfare of kits is lower in outdoor systems compared to the other systems and that the welfare is higher in elevated pens than in the other systems. Finally, it is likely to extremely likely (certainty 66-99%) that the welfare of growing rabbits is lower in conventional cages compared to the other systems and that the welfare is higher in elevated pens than in the other systems. Ranking of the welfare consequences allowed an analysis of the main welfare consequences within each system and rabbit category. It was concluded that for reproducing does, as well as growing rabbits, welfare consequences related to behavioural restrictions were more prominent in conventional cages, elevated pens and enriched cages, whereas those related to health problems were more important in floor pens, outdoor and organic systems. Housing in organic rabbit farming is diverse, which can result in different welfare consequences, but the overall welfare impact scores suggest that welfare in organic systems is generally good.

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“…It has been suggested that the condition has a heritable component [ 7 ], and that the inability of some individuals to cope with the stress of captivity could be genetically transmitted. This idea is strengthened by the fact that not all animals that experience suboptimal or stressful environments demonstrate self-mutilating or other abnormal repetitive behaviors [ 34 ]. However, there are no previous studies providing heritability estimates for fur-chewing for chinchillas.…”

Section: Discussionmentioning

confidence: 99%

Determination of the Genetic Component of Fur-Chewing in Chinchillas (Chinchilla lanigera) and Its Economic Impact

González

Yáñez

Tadich

2018

Animals

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Simple SummaryMany chinchillas kept in captivity develop fur-chewing. This behavior does not only affect fur price, but most importantly it can be the result of an animal welfare problem. The causes of this behavior are not well understood and a genetic component could exist. This is why the aim of this study was to determine the genetic component and the effect of this behavior on fur price. The data from a commercial fur-farm was used, it included information on 10,196 chinchillas recorded between 1990 and 2011. The heritability of the behavior and its effect on fur price were determined. The results show a significant genetic variation in fur-chewing with an estimated heritability of 0.16. At the same time, the behavior had an important negative effect on fur price. The selection and management practices used in fur-farming should be improved in order to decrease the incidence of this behavior.AbstractFur-chewing is a common behavioral disorder developed by chinchillas kept in confinement that can indicate a past or present welfare problem. It also has a negative productive impact associated. The aim of this study was to determine the genetic component of fur-chewing, and the effect of this undesired behavior on fur price in a commercial fur-farming system of chinchillas (Chinchilla lanigera). The data for the analysis was derived from a commercial population of 10,196 chinchillas, recorded between the years 1990 and 2011. For determining differences in fur price according to presence of fur-chewing behavior, analysis of variance (ANOVA) was used, considering 3007 animals. For estimation of variance components of fur-chewing a sire-dam threshold (probit) mixed model was used, using data of 9, 033 individuals, and then heritability on the underlying liability scale was calculated. The analysis revealed a significant negative impact on fur price from fur-chewing chinchillas (p-value < 0.05). In addition, the study showed that fur-chewing presents significant genetic variation, with an estimated heritability of 0.16. The presentation of fur-chewing should be taken into account when selecting broodstock in these systems, in order to reduce the number of affected individuals.

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Behavioral Dermatopathies in Small Mammals

Cited by 15 publications

References 49 publications

Absence of strong strain effects in behavioral analyses ofShank3-deficient mice

Absence of strong strain effects in behavioral analyses ofShank3-deficient mice

Health and welfare of rabbits farmed in different production systems

Determination of the Genetic Component of Fur-Chewing in Chinchillas (Chinchilla lanigera) and Its Economic Impact

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