Behavioral differences between male and female rats: Effects of gonadal hormones on learning and memory

Haaren, Frans van; Hest, Annemieke van; Heinsbroek, Rob P.W.

doi:10.1016/s0149-7634(05)80157-5

Cited by 162 publications

(92 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Activity counts in X-and Z-axes were recorded every minute for 22 h. All measurements were carried out on day 42. Male mice were used to avoid influence of cyclical changes in female sex hormones on glucose homeostasis, but it should be noted that female rodents display increased activity levels compared to males (van Haaren et al 1990). …”

Section: Measurement Of Indirect Calorimetry Energy Expenditure and mentioning

confidence: 99%

Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1-30) and GIP(1-42) in high fat fed mice

Gault¹,

Porter²,

Irwin³

et al. 2011

Journal of Endocrinology

View full text Add to dashboard Cite

Glucose-dependent insulinotropic polypeptide (GIP) is a 42 amino acid hormone secreted from intestinal K-cells, which exhibits a number of actions including stimulation of insulin release. A truncated form, GIP(1-30), has recently been demonstrated in intestine and islet a-cells. To evaluate the potential physiological significance of this naturally occurring form of GIP, the present study has examined and compared the bioactivity of enzymatically stabilised forms, [D-Ala Twice-daily injection of GIP peptides for 42 days had no significant effect on food intake or body weight. However, non-fasting glucose levels were significantly lowered, and insulin levels were elevated in both treatment groups compared to saline controls. The glycaemic response to i.p. In contrast, ambulatory activity was significantly (P!0 . 05) elevated during the light phase in both GIP treatment groups compared to saline controls. The results reveal that sustained GIP receptor activation exerts a spectrum of beneficial metabolic effects in high-fat fed mice. However, no differences were discernable between the biological actions of the enzyme-resistant analogues of the naturally occurring forms, GIP(1-30) and GIP(1-42).

show abstract

Section: Measurement Of Indirect Calorimetry Energy Expenditure and mentioning

confidence: 99%

Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1-30) and GIP(1-42) in high fat fed mice

Gault¹,

Porter²,

Irwin³

et al. 2011

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…While it is likely that the crew will consist of both male and female astronauts, there has been little research on the effects of exposure to HZE particles on central nervous system function and cognitive performance in female subjects. Both exposure to HZE particles [4][5][6][7][8][9] and the gonadal hormone environment [10][11][12][13][14][15] can affect neuronal function and cognitive performance. As such, it is possible that males and females may respond to HZE particle irradiation differently.…”

Section: Introductionmentioning

confidence: 99%

Effects of 17<i>β</i>-Estradiol on Cognitive Performance of Ovariectomized Female Rats Exposed to Space Radiation

Rabin¹,

Carrihill-Knoll²,

Long³

et al. 2013

JBBS

View full text Add to dashboard Cite

On exploratory class missions to other planets astronauts will be exposed to types and doses of radiation that are not experienced in low earth orbit. While it is likely that the crew will consist of both male and female astronauts, there has been little research on the effects of exposure to space radiation on central nervous system function and cognitive performance in female subjects. Because estrogen can function as a neuroprotectant, the present experiments were designed to evaluate whether or not the presence or absence of estrogen at the time of irradiation would affect the susceptibility to the neurocognitive effects of exposure to 56 Fe particles in female rats. Capsules containing 17β-estradiol or vehicle were implanted in ovariectomized rats three days prior to exposure 56 Fe particles (50 -200 cGy, 1000 MeV/n). Cognitive performance was evaluated using novel object recognition memory to measure learning and memory and operant responding on an ascending fixed-ratio schedule to measure changes in motivation and in the responsiveness to environmental contingencies. The results indicated the estrogen does not function as a neuroprotectant to minimize the cognitive effects of exposure to 56 Fe particles. However, the presence/absence of estrogen at the time of irradiation could modulate the responsiveness of the subject to the disruptive effects of exposure to HZE particles on the performance of specific cognitive tasks.

show abstract

“…In typical operant situations, normal male rats tend to emit higher overall response rates than females. Ratio schedules, which require a specified number of responses for reinforcement delivery, appear to tax a food-motivated function labeled as "behavioral perseverance" (34). Male rats display foodmotivated perseverance across a number of behavioral manipulations.…”

Section: Schedule-controlled Operant Performancementioning

confidence: 99%

Sexually dimorphic nonreproductive behaviors as indicators of endocrine disruption.

Weiss

2002

Environ Health Perspect

View full text Add to dashboard Cite

Measures of cognitive and other behaviors not specifically related to reproduction are often sexlinked. Males and females perform differently on many tasks and often interact with members of their species in dissimilar ways. If such differences are diminished, reversed, or widened by prenatal chemical exposures, a reasonable inference is that exposure interfered with sexual differentiation of the brain, largely, but not exclusively, through interference with the actions of gonadal hormones. Explicit recognition of sex differences in performance is not a prominent feature of toxicity testing, however, except for reproduction studies, and is not a recognized criterion in developmental neurotoxicity testing. In contrast to the low visibility accorded sex differences in testing protocols for the assessment of developmental neurotoxicity, the literature is

show abstract

Behavioral differences between male and female rats: Effects of gonadal hormones on learning and memory

Cited by 162 publications

References 127 publications

Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1-30) and GIP(1-42) in high fat fed mice

Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1-30) and GIP(1-42) in high fat fed mice

Effects of 17<i>β</i>-Estradiol on Cognitive Performance of Ovariectomized Female Rats Exposed to Space Radiation

Sexually dimorphic nonreproductive behaviors as indicators of endocrine disruption.

Contact Info

Product

Resources

About

Behavioral differences between male and female rats: Effects of gonadal hormones on learning and memory

Cited by 162 publications

References 127 publications

Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1-30) and GIP(1-42) in high fat fed mice

Comparison of sub-chronic metabolic effects of stable forms of naturally occurring GIP(1-30) and GIP(1-42) in high fat fed mice

Effects of 17&lt;i&gt;β&lt;/i&gt;-Estradiol on Cognitive Performance of Ovariectomized Female Rats Exposed to Space Radiation

Sexually dimorphic nonreproductive behaviors as indicators of endocrine disruption.

Contact Info

Product

Resources

About

Effects of 17<i>β</i>-Estradiol on Cognitive Performance of Ovariectomized Female Rats Exposed to Space Radiation