Behavioral disinhibition requires dopamine receptor activation

Gaalen, Marcel M. van; Brueggeman, Reinhild J.; Bronius, Patricia F. C.; Schoffelmeer, Anton N. M.; Vanderschuren, Louk J. M. J.

doi:10.1007/s00213-006-0396-1

Cited by 218 publications

(233 citation statements)

References 59 publications

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“…In fact, premature responses in both groups were above and below, respectively, the normal average for Wistar and Sprague-Dawley rats (Moreno et al, unpublished data from our laboratory; van Gaalen et al, 2006).…”

Section: Increased Adjunctive Drinking Acquisition In Rha-i Ratsmentioning

confidence: 79%

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Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

134

106

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for rapid vs extremely poor acquisition of active avoidance behavior in a shuttle-box has generated two phenotypes with different emotional and motivational profiles. The phenotypic traits of the Roman rat lines/strains (outbred or inbred, respectively) include differences in sensation/novelty seeking, anxiety/fearfulness, stress responsivity, and susceptibility to addictive substances. We designed this study to characterize differences between the inbred RHA-I and RLA-I strains in the impulsivity trait by evaluating different aspects of the multifaceted nature of impulsive behaviors using two different models of impulsivity, the delay-discounting task and five-choice serial reaction time (5-CSRT) task. Previously, rats were evaluated on a schedule-induced polydipsia (SIP) task that has been suggested as a model of obsessive-compulsive disorder. RHA-I rats showed an increased acquisition of the SIP task, higher choice impulsivity in the delay-discounting task, and poor inhibitory control as shown by increased premature responses in the 5-CSRT task. Therefore, RHA-I rats manifested an increased impulsivity phenotype compared with RLA-I rats. Moreover, these differences in impulsivity were associated with basal neurochemical differences in striatum and nucleus accumbens monoamines found between the two strains. These findings characterize the Roman rat strains as a valid model for studying the different aspects of impulsive behavior and for analyzing the mechanisms involved in individual predisposition to impulsivity and its related psychopathologies.

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Section: Increased Adjunctive Drinking Acquisition In Rha-i Ratsmentioning

confidence: 79%

“…Animals were required to respond to brief flashes of light presented randomly in one of five spatial locations (Carli et al, 1983). Pre-training and training were based on previous procedures with subtle modifications (Robbins, 2002;van Gaalen et al, 2006). Rats were habituated to the apparatus over 2 days for 20 min/session.…”

Section: Methodsmentioning

confidence: 99%

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

134

106

View full text Add to dashboard Cite

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“…That is, marmosets with decreased striatal dopamine function were significantly more task engaged than control marmosets (Crofts et al, 2001). In addition, findings from the 5-CSRTT indicate that premature responding (or failure of behavioral inhibition) can be decreased in rats by the dopamine D 2 receptor agonist quinpirole, which is thought to decrease dopaminergic neurotransmission by stimulating presynaptic dopamine D 2 receptors (Passetti et al, 2003); while increasing dopamine neurotransmission with amphetamine and cocaine (Cole and Robbins, 1987;Harrison et al, 1997;van Gaalen et al, 2006) and with dopamine reuptake inhibitors (van Gaalen et al, 2006) increases premature responding, an effect that is suppressed with dopamine D 2 receptor antagonism (van Gaalen et al, 2006) and dopamine depletion (Cole and Robbins, 1987). Together, these findings suggest that the findings by Roesch-Ely et al (2005) of decreased Stroop interference (ie, improved attentional control) with stimulation of D 2 receptors may reflect a presynaptic mechanism leading to decreased dopamine neurotransmission.…”

Section: Discussionmentioning

confidence: 99%

Acute Serotonin and Dopamine Depletion Improves Attentional Control: Findings from the Stroop Task

Scholes

Harrison

O’Neill

et al. 2006

Neuropsychopharmacol

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Schizophrenia is associated with impairments of attentional control on classic experimental paradigms such as the Stroop task. However, at a basic level the neurochemical mechanisms that may be responsible for such impairments are poorly understood. In this study, we sought to investigate the influence of brain monoamine function on Stroop task performance in healthy participants using the established methods of acute dietary serotonin, dopamine, and combined monoamine depletion. The study was a double-blind placebo controlled design in which 12 healthy male participants completed the Stroop task under four acute treatment conditions: (a) balanced/placebo control, (b) acute tryptophan depletion, (c) acute tyrosine/phenylalanine depletion, and (d) acute tyrosine/phenylalanine/tryptophan depletion (combined monoamine depletion). Decreased Stroop interference indicating improved attentional control was observed after both tryptophan depletion and tyrosine/phenylalanine depletion, while there was no significant change in interference after combined monoamine depletion. Findings suggest that reduced tonic dopamine or serotonin activity within specific neural circuits (such as the striatum, anterior cingulate, or prefrontal cortex) may play a critical role in attentional control, possibly by improving gating of information via reducing noise in monoaminergic systems. These findings enhance our understanding of the neurochemical basis of attentional control and the possible cause of attentional control deficits in schizophrenia.

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“…Dopamine (DA) is a neurotransmitter that is critically involved in the approach system and reward-related behavior [Depue and Collins, 1999;van Gaalen et al, 2006]. Thus, it follows that if conduct problems are related to dysfunction in the approach system, then DA is likely to be involved.…”

Section: Dopaminergic Correlates Of Conduct Disordermentioning

confidence: 99%

Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover

Grigorenko

DeYoung

Eastman

et al. 2010

Aggressive Behavior

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A number of dopamine-related genes have been implicated in the etiology of violent behavior and conduct problems. Of these genes, the ones that code for the enzymes that influence the turnover of dopamine (DA) have received the most attention. In this study, we investigated 12 genetic polymorphisms in four genes involved with DA functioning (COMT, MAOA and MAOB, and DbH) in 179 incarcerated male Russian adolescents and two groups of matched controls: boys without criminal records referred to by their teachers as (a) ''troubled-behavior-free'' boys, n 5 182; and (b) ''troubled-behavior'' boys, n 5 60. The participants were classified as (1) being incarcerated or not, (2) having the DSM-IV diagnosis of conduct disorder (CD) or not, and (3) having committed violent or nonviolent crimes (for the incarcerated individuals only). The findings indicate that, although no single genetic variant in any of the four genes differentiated individuals in the investigated groups, various linear combinations (i.e., haplotypes) and nonlinear combinations (i.e., interactions between variants within and across genes) of genetic variants resulted in informative and robust classifications for two of the three groupings. These combinations of genetic variants differentiated individuals in incarceration vs. nonincarcerated and CD vs. no-CD groups; no informative combinations were established consistently for the grouping by crime within the incarcerated individuals. This study underscores the importance of considering multiple rather than single markers within candidate genes and their additive and interactive combinations, both with themselves and with nongenetic indicators, while attempting to understand the genetic background of such complex behaviors as serious conduct problems. Aggr. Behav. 36:158-176, 2010.

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Behavioral disinhibition requires dopamine receptor activation

Cited by 218 publications

References 59 publications

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Acute Serotonin and Dopamine Depletion Improves Attentional Control: Findings from the Stroop Task

Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover

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