Behavioral effects and ChE measures after acute and repeated administration of malathion in rats

Assini, Fabrício Luiz; Zanette, Kênia D.; Brocardo, Patrícia S.; Pandolfo, Pablo; Rodrigues, Ana Lúcia S.; Takahashi, Reinaldo Ν.

doi:10.1016/j.etap.2005.05.007

Cited by 34 publications

(18 citation statements)

References 42 publications

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“…8 On the same concern kidney was one of the target organs of experimental animals attacked by acute, sub-chronic and chronic exposure to OP. 9 Besides, it has been postulated that OP produced oxidative stress in different tissues, such as kidney of rats and mice, through the formation of reactive oxygen species (ROS). 10 Melissa officinalis belongs to the Laminaceae family, being a perennial herb.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

El-Raheem¹

2015

MOJT

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It has been confirmed that organophosphorus compounds OP altered glucose homeostasis. Considerable experimental and clinical evidences have contributed the beneficial effects of antioxidant compounds in plant extract on hepatorenal toxicity. The aim of this study was to evaluate whether Melissa officinalis extract, was able to ameliorative hepatorenal injury induced by organophosphorus Malathion. Malathion at 27mg/kg bw was administered to rats alone or in combination with Melissa officinalis extract at 200mg/kg bw. Malathion decreases feed intake and body weight as well as liver and kidneys weight. Moreover, Malathion increases the levels of various serum marker enzymes AST, ALT and ALP. A significant increase in the level of serum urea, uric acid and creatinine in response to ML treatment. As well as ML induced increase in MDA in liver and kidneys while induced decreases in the activities of SOD, GPx and CAT. Co-administration of malathion with Melissa officinalis extract resulted in restoration of all tested parameter. These results may be due to the significant increase recorded in acetylcholine esterase (Ach E) activity invivo after co administration of malathion and Melissa officinalis extract. In histological study of liver and kidney, Malathion induced damage in liver and kidneys. However, MO administration to ML-treated animals resulted in overall improvement in liver and kidneys damage, emphasizing its antioxidant role. In light of the available data, it can deduce that ML-induced lipid peroxidation, oxidative stress, liver and kidneys damage rats, and conjoint supplementation of MO has resulted in pronounced ameliorating effect in all tested parameter and histological picture of liver and kidney. MOJ Toxicology Research ArticleOpen Access Ameliorative role of melissa officinalis against hepatorenal toxicities of organophosphorus malathion in male rats 104Copyright: ©2015 Sief et al. Citation:Sief MM, Khalil FA, Abou-Arab AA, et al. Ameliorative role of melissa officinalis against hepatorenal toxicities of organophosphorus malathion in male rats.

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Section: Introductionmentioning

confidence: 99%

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

El-Raheem¹

2015

MOJT

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“…Along with the induction of depressive-like behaviour in animal models of depression [10,12], malathion toxicity causes impairment in the antioxidant defense [11,12], and produces an increase in several markers of oxidative stress in the rat brain, such as lipid peroxidation, protein carbonylation and DNA damage [13][14][15], but gender differences have not yet been studied.…”

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confidence: 99%

“…Despite the limitation of population analysis, neurobehavioural impairment might be the consequence of an acute poisoning, and possibly the consequence of relatively high and prolonged exposure [8]. Organophosphate has been considered as an important risk factor for depression and correlated to suicide attempts [9] and has been used as a model of depressive-like behaviour in animals [10]. Malathion, a pesticide widely used to fight fleas, lice, mosquitoes and flies, is thought to be one of the main agents leading to human organophosphate intoxication in the Santa Catarina state, Southern Brazil [11].…”

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confidence: 99%

“…Organophosphate has been considered as an important risk factor for depression and correlated to suicide attempts [9] and has been used as a model of depressive-like behaviour in animals [10]. Malathion, a pesticide widely used to fight fleas, lice, mosquitoes and flies, is thought to be one of the main agents leading to human organophosphate intoxication in the Santa Catarina state, Southern Brazil [11].Along with the induction of depressive-like behaviour in animal models of depression [10,12], malathion toxicity causes impairment in the antioxidant defense [11,12], and produces an increase in several markers of oxidative stress in the rat brain, such as lipid peroxidation, protein carbonylation and DNA damage [13][14][15], but gender differences have not yet been studied.The effects of metals have been under investigation for decades and attention is naturally focused on the most toxic metals such as cadmium, nickel, lead, mercury and arsenic [1]. On the other side, zinc has been considered a relatively safe metal [16] owing to its auto-regulatory metabolism [17] and little attention has been paid to its acute toxicity.…”

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confidence: 99%

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Gender Effects of Acute Malathion or Zinc Exposure on the Antioxidant Response of Rat Hippocampus and Cerebral Cortex

Maris

Franco

Mitozo³

et al. 2010

Basic Clin Pharma Tox

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Gender is one of the most important factors in mammalian development and response to exogenous agents. Although there is increasing evidence that health effects of toxic xenobiotics differ in prevalence or are manifested differently in male and female, the molecular mechanisms related to these events remain unclear. In order to investigate the possible influence of gender, male and female Wistar rats from the same litter were exposed to zinc chloride (5 mg ⁄ kg, i.p.) or malathion (250 mg ⁄ kg, i.p.) 24 hr prior to the analyses of biochemical parameters related to the cholinergic and glutathione-antioxidant systems in cerebral cortex and hippocampus. After treatments, acetylcholinesterase (AChE) activity was reduced in the hippocampus and cerebral cortex of male and female rats treated with malathion, but the effect was more pronounced in the male group. Glutathione reductase (GR) and c-glutamyl-transpeptidase activities were reduced in the hippocampus of males and females and a gender-specific effect of malathion was seen for glutathione S-transferase (GST), which was decreased only in male hippocampus and cortex, and for male cortical GR. Zinc chloride treatment decreased AChE activity in male and female cerebral cortex, with no obvious effect in the hippocampus. Male-specific antioxidant-related enzyme activity reductions were seen after zinc treatment for cortical GR, GST, glutathione peroxidase and glucose-6-phosphate dehydrogenase; and hippocampal GR. These results clearly demonstrate a greater detrimental effect on antioxidant-related enzyme activities in male hippocampus and cerebral cortex when rats were acutely exposed to malathion and zinc, demonstrating that the research on gender-related differences in health effects caused by xenobiotic and ⁄ or essential elements requires further attention.Gender-based differences in the metabolism constitute a major topic in biology, and sex-dependent toxicity permeates the literature for a series of factors. Some examples of research areas where gender differences are important determinants of toxicity are: metal toxicity [1], pharmacokinetics [2], hormone metabolism [3], xenobiotics metabolism [4] and traumatic injury vulnerability [5]. The relevance of studying gender-dependent toxicity has been stressed before: 'Gender may be the most important factor in mammalian development and response to exogenous agents' [6].Incidental or intentional organophosphate intoxication is a relevant health problem in developing countries [7]. Despite the limitation of population analysis, neurobehavioural impairment might be the consequence of an acute poisoning, and possibly the consequence of relatively high and prolonged exposure [8]. Organophosphate has been considered as an important risk factor for depression and correlated to suicide attempts [9] and has been used as a model of depressive-like behaviour in animals [10]. Malathion, a pesticide widely used to fight fleas, lice, mosquitoes and flies, is thought to be one of the main agents leading to human organop...

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“…An earlier study reported that adult female's rats showed an altered level of anxiety after being exposed to acute (50, 100, 250 mg/kg ip) and subchronic (25, 50, 100 mg/kg ip) intoxication of Malathion [42].…”

Section: Effects Of Dimethoate On Anxiety Behaviormentioning

confidence: 99%

Effects of Dimethoate Exposure on Locomotor Activity and Anxiety-Like Behavior in Female Wistar Rat

Samih¹,

N’Go²,

Belaaouja³

et al. 2017

JBBS

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Developmental exposure to organophosphate insecticide is well known to induce neurobehavioral impairments, at late period. The present study aims to investigate the effects of subchronic exposure to Dimethoate, on locomotors skills and anxiety like behavior among wistar rat. Two groups of female's rats are used. The intoxicated group receives daily, during five weeks, by intragastric gavage, a dose of Dimethoate dissolved in corn oil (100 mg/kg body weight). The control group receives only the corn oil. Spontaneous locomotors activity is evaluated using the Open Field test (OF) and anxiety-like behavior is measured using Elevated Plus-Maze (EPM). Dimethoate induced significant impairment of spontaneous locomotors activities, which is reflected by high decrease of number of squares crossed (SC) in OF. Females exposed to Dimethoate develop further anxiety-like response, expressed by significant reductions of the time spent in open arm of Elevated Plus-Maze.

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Behavioral effects and ChE measures after acute and repeated administration of malathion in rats

Cited by 34 publications

References 42 publications

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

Gender Effects of Acute Malathion or Zinc Exposure on the Antioxidant Response of Rat Hippocampus and Cerebral Cortex

Effects of Dimethoate Exposure on Locomotor Activity and Anxiety-Like Behavior in Female Wistar Rat

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