Behavioral effects and neural changes induced by continuous and not continuous treadmill training, post bilateral cerebral ischemia in gerbils

Kitabatake, Takae Tamy; Marini, Luana de Castro; Gonçalves, Renata Batagini; Bertolino, Guilherme; Souza, Hugo Celso Dutra de; Araujo, João Eduardo de

doi:10.1016/j.bbr.2015.04.057

Cited by 11 publications

(8 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The stimulation protocol was set at a fixed speed of 5 m/min for 15 min, with a 0 % grade of inclination, without speed increases and a total stimulation period of five days. (8)…”

Section: Treadmill Trainingmentioning

confidence: 99%

“…(6,7) Using a bilateral carotid occlusion model for 5 minutes followed by reperfusion results in significant damages to the striatum, hippocampal CA1 area, and motor cortex M. (7) Previous studies have shown that treadmill training can potentially prevent neuronal death, particularly in the hippocampus, which is responsible for memory, and other areas associated with motor behavior. (7,8,9) The results of previous studies underscore the importance of optimizing the training dose. (10) Given the ongoing discussion surrounding time window, target, and treatment duration in animal stroke and drug therapy models, (11) this study explores the potential of concomitant drug therapy with exercise.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Motor behavior improvement in ischemic gerbils by cholinergic receptor activation and treadmill training

Do Espírito Santo,

Zhang,

Kitabatake

et al. 2024

Interdisciplinary Rehabilitation / Rehabilitacion Interdiscipli

Self Cite

View full text Add to dashboard Cite

Introduction: Treadmill exercise training is one of the most investigated non-pharmacological treatment options for experimental brain ischemia. However, the cholinergic system is essential for improving motor behavior responses. Objective: To analyze the effects of a nicotinic acetylcholine receptor (nAChR) agonist (1, 2, and 4 mg/kg) on the motor behavior of ischemic gerbils subjected to forced treadmill training.Methods: In this experimental study, 72 gerbils, weighing 65–80 g, were divided into eight groups: Sal, Ni1, Ni2, Ni4, I, INi1, INi2, and INi4. Behavioral assessment was initiated 24 hours after the last motor stimulation on the treadmill. Rotarod test (RR) was employed to analyze animal behavior. The data were analyzed using one-way analysis of variance (ANOVA), and the Newman-Keuls post hoc test evidenced differences detected between groups. Results: Data regarding the RR test revealed decreased time spent on the RR apparatus for the Ni1, Ni4, and I groups compared to the Sal and Ni2 groups. However, the INi1 and INi2 groups showed increased time spent compared with the ischemia and INi4 groups (F7,64=4.63; p<0.05).Conclusions: The present study indicates that treadmill training with a concomitant 1 and 2 mg/kg of nAChR agonist effectively improves the behavior of ischemic gerbils.

show abstract

“…The stimulation protocol was set at a fixed speed of 5 m/min for 15 min, with a 0 % grade of inclination, without speed increases and a total stimulation period of five days. (8)…”

Section: Treadmill Trainingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Motor behavior improvement in ischemic gerbils by cholinergic receptor activation and treadmill training

Do Espírito Santo,

Zhang,

Kitabatake

et al. 2024

Interdisciplinary Rehabilitation / Rehabilitacion Interdiscipli

Self Cite

View full text Add to dashboard Cite

show abstract

“…As such, gerbils have been extensively used in the fields of aging [41][42][43], metabolism [44][45][46], infection [47,48], immune system [49,50], and cancer [51,52]. In neuroscience research, gerbils have been extensively used to study sensory systems [53][54][55][56][57][58], neurological diseases [54,[59][60][61] and brain structures [62][63][64]. Gerbils have benefits especially in visual studies, because gerbils are physiologically, anatomically, and behaviorally different from rats and mice, although they belong to the same family [65][66][67][68].…”

Section: Introductionmentioning

confidence: 99%

Immunocytochemical localization of nitric oxide synthase-containing neurons in the visual cortex of the Mongolian gerbil

Kuai,

Jeong,

Jeon

2024

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. www.journals.viamedica.pl/folia_histochemica_cytobiologica ©Polish Society for Histochemistry and Cytochemistry

show abstract

“…Gerbils are widely used as research models in areas such as aging [ 48 ], metabolism [ 49 , 50 , 51 , 52 , 53 , 54 ], anatomy [ 55 , 56 ], and parasitic diseases [ 57 , 58 ]. In neuroscience research, gerbils have been widely used to study sensory systems [ 59 , 60 , 61 , 62 , 63 ], neural diseases [ 61 , 64 , 65 , 66 ], and brain structure [ 67 , 68 , 69 ]. Mice and rats are common in biomedical and neuroscience research due to their genetic manipulability and well-published data.…”

Section: Introductionmentioning

confidence: 99%

The Organization of Somatostatin-Immunoreactive Cells in the Visual Cortex of the Gerbil

et al. 2022

View full text Add to dashboard Cite

Somatostatin (SST) is widely expressed in the brain and plays various, vital roles involved in neuromodulation. The purpose of this study is to characterize the organization of SST neurons in the Mongolian gerbil visual cortex (VC) using immunocytochemistry, quantitative analysis, and confocal microscopy. As a diurnal animal, the Mongolian gerbil provides us with a different perspective to other commonly used nocturnal rodent models. In this study, SST neurons were located in all layers of the VC except in layer I; they were most common in layer V. Most SST neurons were multipolar round/oval or stellate cells. No pyramidal neurons were found. Moreover, 2-color immunofluorescence revealed that only 33.50%, 24.05%, 16.73%, 0%, and 64.57% of SST neurons contained gamma-aminobutyric acid, calbindin-D28K, calretinin, parvalbumin, and calcium/calmodulin-dependent protein kinase II, respectively. In contrast, neuropeptide Y and nitric oxide synthase were abundantly expressed, with 80.07% and 75.41% in SST neurons, respectively. Our immunocytochemical analyses of SST with D1 and D2 dopamine receptors and choline acetyltransferase, α7 and β2 nicotinic acetylcholine receptors suggest that dopaminergic and cholinergic fibers contact some SST neurons. The results showed some distinguishable features of SST neurons and provided some insight into their afferent circuitry in the gerbil VC. These findings may support future studies investigating the role of SST neurons in visual processing.

show abstract

Behavioral effects and neural changes induced by continuous and not continuous treadmill training, post bilateral cerebral ischemia in gerbils

Cited by 11 publications

References 42 publications

Motor behavior improvement in ischemic gerbils by cholinergic receptor activation and treadmill training

Motor behavior improvement in ischemic gerbils by cholinergic receptor activation and treadmill training

Immunocytochemical localization of nitric oxide synthase-containing neurons in the visual cortex of the Mongolian gerbil

The Organization of Somatostatin-Immunoreactive Cells in the Visual Cortex of the Gerbil

Contact Info

Product

Resources

About