Behavioral effects of acute stimulation of κ-opioid receptors during lactation

Teodorov, Elizabeth; Tomita, Aline T.; Banon, Gabriela Paola Ribeiro; Gil, Iara G.; Bernardi, Maria Martha; Felício, Luciano Freitas

doi:10.1016/j.pbb.2008.04.008

Cited by 11 publications

(11 citation statements)

References 34 publications

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“…Recently, it was demonstrated that the PAG is an area susceptible to opioids and expresses the encoded µ-opioid receptor Oprm1 and other genes related to κ and δ receptors, and that morphine specificity in this area (23,24) is supported by the observation that infusions of naloxone into this area restore maternal behaviors (18). In the present study, therefore, we evaluated the behavioral effects of local opioidergic stimulation of the rlPAG.…”

Section: Discussionmentioning

confidence: 96%

Morphine infusions into the rostrolateral periaqueductal gray affect maternal behaviors

Moura

Canteras

Sukikara

et al. 2010

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 96%

Morphine infusions into the rostrolateral periaqueductal gray affect maternal behaviors

Moura

Canteras

Sukikara

et al. 2010

Braz J Med Biol Res

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“…A previous study from our laboratory has reported the presence of kappa receptor protein in the PAG of both virgin and lactating rats (8). The present study investigated the expression of Oprm1 , Oprk1 , and Oprd1 in the PAG of female rats by evaluating the gene expression of mu-, kappa-, and delta-opioid receptors in the PAG of animals treated with an acute injection of U69593.…”

Section: Discussionmentioning

confidence: 93%

“…Maternal aggression and survival strategies involving stressful situations have also been reported to be influenced by opioid receptors (16,17,32). A previous study reported that stimulation of kappa-opioid receptors using different doses of U69593 interferes with maternal behavior (8). Behavioral data reported in the present study show that peripheral injection of 0.15 mg/kg of the kappa agonist inhibits maternal behavior in lactating rats.…”

Section: Discussionmentioning

confidence: 99%

Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression

Teodorov

Ferrari

Fior-Chadi

et al. 2012

Braz J Med Biol Res

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The periaqueductal gray (PAG) has been reported to be a location for opioid regulation of pain and a potential site for behavioral selection in females. Opioid-mediated behavioral and physiological responses differ according to the activity of opioid receptor subtypes. The present study investigated the effects of the peripheral injection of the kappa-opioid receptor agonist U69593 into the dorsal subcutaneous region of animals on maternal behavior and on Oprk1 gene activity in the PAG of female rats. Female Wistar rats weighing 200-250 g at the beginning of the study were randomly divided into 2 groups for maternal behavior and gene expression experiments. On day 5, pups were removed at 7:00 am and placed in another home cage that was distant from their mother. Thirty minutes after removing the pups, the dams were treated with U69593 (0.15 mg/kg, sc) or 0.9% saline (up to 1 mL/kg) and after 30 min were evaluated in the maternal behavior test. Latencies in seconds for pup retrieval, grouping, crouching, and full maternal behavior were scored. The results showed that U69593 administration inhibited maternal behavior (P < 0.05) because a lower percentage of U69593 group dams showed retrieval of first pup, retrieving all pups, grouping, crouching and displaying full maternal behavior compared to the saline group. Opioid gene expression was evaluated using real-time reverse-transcription polymerase chain reaction (RT-PCR). A single injection of U69593 increased Oprk1 PAG expression in both virgin (P < 0.05) and lactating female rats (P < 0.01), with no significant effect on Oprm1 or Oprd1 gene activity. Thus, the expression of kappa-opioid receptors in the PAG may be modulated by single opioid receptor stimulation and behavioral meaningful opioidergic transmission in the adult female might occur simultaneously to specific changes in gene expression of kappa-opioid receptor subtype. This is yet another alert for the complex role of the opioid system in female reproduction.

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“…Os receptores tipo κ, sítios preferenciais para ligação de dinorfinas, têm papel importante na imunidade, percepção dolorosa, fisiológica neuroendócrina, comportamento afetivo e aspectos cognitivos, podendo também modular o comportamento reprodutivo em fêmeas (TEODOROV et al, 2008). O receptor opióide do tipo κ possui alta afinidade por dinorfina A, um agonista endógeno, e por U50,488 e U69593; porém, não há ligação com agonista µ1-seletivo DAMGO ou com o agonista δ1-seletivo DPLPE.…”

Section: Discussionunclassified

“…Recent studies suggested the involvement of these receptors in the physiological selection of behavior during lactation Teodorov et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Efeitos da morfina em fases distintas da gestação de ratas: comportamento maternal, desenvolvimento físico e neurocomportamental das proles e biologia molecular dos receptores opióides.

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Behavioral effects of acute stimulation of κ-opioid receptors during lactation

Cited by 11 publications

References 34 publications

Morphine infusions into the rostrolateral periaqueductal gray affect maternal behaviors

Morphine infusions into the rostrolateral periaqueductal gray affect maternal behaviors

Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression

Efeitos da morfina em fases distintas da gestação de ratas: comportamento maternal, desenvolvimento físico e neurocomportamental das proles e biologia molecular dos receptores opióides.

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