Behavioral effects of CCKB receptor ligands in a validated simulation of panic anxiety in rats

Jenck, F.; Martin, James R.; Moreau, Jean‐Luc

doi:10.1016/s0924-977x(96)00033-8

Cited by 28 publications

(7 citation statements)

References 32 publications

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“…Whilst acute does of the SSRIs fluoxetine and fluvoxamine potentiate panic symptoms in PD patients (Saran and Halaris 1989;Denboer and Westenberg 1990), they do not increase anxiety in the dPAG stimulation model after acute administration (Jenck et al 1990(Jenck et al , 1998b. Moreover, drugs which have no effect on panic symptoms in patients, such as the CCK B antagonist L-365,260 and the antipsychotic haloperidol, have proven antiaversive in this test (Jenck et al 1989(Jenck et al , 1996. Along with mCPP, the panicogenic agent caffeine also fails to increase one-way escape in the elevated Tmaze (Graeff et al 1998).…”

Section: Discussionmentioning

confidence: 99%

5-HT 2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze

2002

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Section: Discussionmentioning

confidence: 99%

5-HT 2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze

2002

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“…The involvement of CCK and its by products in the induction of anxiety in humans and in anxiety models in animals is well demonstrated [Van Megen et al, 1996;Jenck et al, 1996;Crawley, 1994;Costall et al, 1991]. Since the activity of CCK is mediated by, or integrated with, the activity of various neurotransmitter systems, it is quite possible that the specific blocking of CCK receptor subtypes is not sufficient to effectively attenuate clinical features of anxiety or their laboratory models.…”

Section: Discussionmentioning

confidence: 99%

CCK‐antagonists in a rat exposed to acute stress: Implication for anxiety associated with post‐traumatic stress disorder

Cohen

Kaplan

Kotler

1999

Depression and Anxiety

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“…Moreover, compounds that failed to alleviate panic symptoms in human (i.e. the antipsychotic haloperidol and the CCKB receptor antagonist L-365,260) produced antiaversive effects in this test [56,58]. These latter ®ndings bring into question the validity of the dPAG-stimulation procedure to reveal a speci®c panic or antipanic pro®le of panic-modulating agents.…”

Section: Panic Disorder (Pd)mentioning

confidence: 94%

Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic

Blanchard

Griebel

Blanchard

2001

Neuroscience &Amp; Biobehavioral Reviews

411

251

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The natural defensive behaviors of laboratory mice have been evaluated in both seminatural and highly structured situations; and characterized in terms of eliciting stimuli, response to pharmacological agents, behavior patterns, and outcome or effect on the social and physical environment. The defense patterns of laboratory mice and rats are generally similar, but mice show risk assessment on initial exposure to highly threatening stimuli while rats do not, while rats display alarm vocalizations, missing in mice. Quantitative differences in freezing and¯ight for laboratory mice and rats appear to largely re¯ect domestication effects, with wild mice and rats more similar to each other. This nexus of detailed within-species and comparative data on defense patterns makes it possible to reliably elicit speci®c defenses in mice or rats in an experimental context, providing well-validated assays of the natural defensive behaviors themselves, as opposed tò models' of defense.The mouse±rat comparisons indicate considerable cross-species generality for these defense patterns, as does a scattered but considerable literature on other mammalian species, generally involving ®eld studies and typically focusing on those aspects of defensive behavior that are visible at a distance, such as vigilance, or¯ight. Although potential homologies between normal mouse and human defense systems should ideally involve all four pattern components (stimulus, organismic factors, response characteristics, outcome), predictive validity in terms of response to drugs active against speci®c defensive psychopathology is the most extensively investigated of these. Flight, as measured in the Mouse Defense Test Battery shows a consistently appropriate response to panicolytic, panicogenic, and panic-neutral drugs, while some other predictive`panic models' (dPAG-stimulation; DMH-inhibition; possibly conditioned suppression of drinking paradigms) also elicit and (indirectly) measure behaviors potentially related to¯ight. Models unrelated to¯ight (e.g. ultrasonic vocalization to conditioned stimuli); or for which¯ight elements may a relatively minor contributor to the behavior measured (Elevated T-maze) are less predictive of panicolytic or panicogenic action. These ®ndings indicate that natural defensive behaviors provide a well-characterized pattern for analysis of effects of genetic or other physiological manipulations in the mouse, and may also serve as a model for analysis of defenserelated human psychopathology. q 2001 Elsevier Science Ltd. All rights reserved. The recent explosion of genetic techniques and genetically modi®ed animals has greatly exacerbated the need for comprehensive, natural, models or assays of behavior that are relevant to mice, the mammalian species of choice for genetic research [25]; and has additionally focused attention on issues of construction and validation of these tests.Minimally, a behavioral model/assay should enable the reliable elicitation and measurement of a qualitatively consistent behavior pattern for ...

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Behavioral effects of CCKB receptor ligands in a validated simulation of panic anxiety in rats

Cited by 28 publications

References 32 publications

5-HT 2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze

5-HT 2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze

CCK‐antagonists in a rat exposed to acute stress: Implication for anxiety associated with post‐traumatic stress disorder

Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic

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