Behavioral effects of chronic stress in Carioca high- and low-conditioned freezing rats

Lages, Yury V.; Maisonnette, Sílvia; Marinho, Beatriz; Rosseti, Flávia P.; Krahe, Thomas E.; Landeira-Fernández, J.

doi:10.1080/10253890.2021.1934445

Cited by 10 publications

(13 citation statements)

References 101 publications

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“…"Carioca" rats, selectively bred to have high or low inherent anxiety responses allow us to assess the direction of the stress-anxiety association. Chronic unpredictable mild stress during development produces a greater increase in later reactions to threat in the high responding rats than in the low (Lages et al, 2021).…”

Section: Genes Environment and Personalitymentioning

confidence: 89%

Non-human contributions to personality neuroscience – from fish through primates. An introduction to the special issue

Lages

McNaughton²

2022

Personality Neuroscience

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The most fundamental emotional systems that show trait control are evolutionarily old and extensively conserved. Psychology in general has benefited from non-human neuroscience and from the analytical simplicity of behaviour in those with simpler nervous systems. It has been argued that integration between personality, psychopathology, and neuroscience is particularly promising if we are to understand the neurobiology of human experience. Here, we provide some general arguments for a non-human approach being at least as productive in relation to personality, psychopathology, and their interface. Some early personality theories were directly linked to psychopathology (e.g., Eysenck, Panksepp, and Cloninger). They shared a common interest in brain systems that naturally led to the use of non-human data; behavioural, neural, and pharmacological. In Eysenck’s case, this also led to the selective breeding, at the Maudsley Institute, of emotionally reactive and non-reactive strains of rat as models of trait neuroticism or trait emotionality. Dimensional personality research and categorical approaches to clinical disorder then drifted apart from each other, from neuropsychology, and from non-human data. Recently, the conceptualizations of both healthy personality and psychopathology have moved towards a common hierarchical trait perspective. Indeed, the proposed two sets of trait dimensions appear similar and may even be eventually the same. We provide, here, an introduction to this special issue of Personality Neuroscience, where the authors provide overviews of detailed areas where non-human data inform human personality and its psychopathology or provide explicit models for translation to human neuroscience. Once all the papers in the issue have appeared, we will also provide a concluding summary of them.

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Section: Genes Environment and Personalitymentioning

confidence: 89%

Non-human contributions to personality neuroscience – from fish through primates. An introduction to the special issue

Lages

McNaughton²

2022

Personality Neuroscience

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“…Similar to the EPM, the open field (OF) is a behavioral test commonly employed to measure innate fear and overall mobility in rodents [ 36 ]. Lages et al (2021) [ 37 ] showed that the CHF male rats have a smaller number of entries in the center of the apparatus in comparison to the CLF group, confirming that CHF rats display an increased anxiety behavioral phenotype. The authors also observed that, compared to CHF rats, CLF male animals expressed a significantly high locomotor activity, which is in accordance with a previous study [ 38 ].…”

Section: Benzodiazepine Treatmentmentioning

confidence: 99%

“…Although serotonergic mechanisms might be involved in the alterations that are observed in CHF male rats [ 32 ], no such evidence yet supports such a hypothesis for the CLF line. Based on the involvement of other monoamines in fear regulation and mood disorder [ 65 , 66 ], and the indications of impulsivity and motor alterations in CLF male animals [ 37 ], the dopaminergic mediation of CLF’s behavior was further investigated. Dopamine takes part in fear acquisition and extinction [ 78 , 79 ], and is a central component in attention-deficit/hyperactivity disorders (ADHD) [ 80 - 83 ].…”

Section: Dopaminergic Circuitrymentioning

confidence: 99%

“…As a consequence, the activation of hippocampal neurons would be potentiated by external stimuli, such as stress [ 119 ]. Indeed, recent results from our group showed that the CHF line is more susceptible to chronic stress [ 37 ]. While the chronic unpredictable mild stress (CUMS) protocol produced subtle behavior alterations in the CLF line, it induced a shift and exacerbation of defensive coping strategies in CHF male rats.…”

Section: Neurophysiological Studiesmentioning

confidence: 99%

“…As mentioned before, CHF rats are more susceptible to the effects of chronic stress, while CLF’s behavior remains unaltered [ 37 ]. This effect can be at least partially derived from alterations in the HPA axis, which is known to play a crucial role in stress control and is closely associated with anxiety disorders [ 142 , 143 ].…”

Section: Endocrine and Metabolic Assaysmentioning

confidence: 99%

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Pharmacological and Physiological Correlates of the Bidirectional Fear Phenotype of the Carioca Rats and Other Bidirectionally Selected Lines

Landeira-Fernández

Lages

Balthazar

et al. 2023

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The Carioca rat lines originated from the selective bidirectional breeding of mates displaying extreme defense responses to contextual conditioned fear. After three generations, two distinct populations could be distinguished: the Carioca High- and Low-conditioned Freezing rats, CHF, and CLF, respectively. Later studies identified strong anxiety-like behaviors in the CHF line, while indications of impulsivity and hyperactivity were prominent in the CLF animals. The present review details the physiological and pharmacological-related findings obtained from these lines. The results discussed here point towards a dysfunctional fear circuitry in CHF rats, including alterations in key brain structures and the serotoninergic system. Moreover, data from these animals highlight important alterations in the stress-processing machinery and its associated systems, such as energy metabolism and antioxidative defense. Finally, evidence of an alteration in the dopaminergic pathway in CLF rats is also debated. Thus, accumulating data gathered over the years, place the Carioca lines as significant animal models for the study of psychiatric disorders, especially fear-related ones like anxiety.

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Tracking puppy development: automated analysis and qualitative behavioral assessment in repeated open field tests

Koçkaya,

Isparta,

Reinhardt

et al. 2024

Vet Res Commun

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Behavioral effects of chronic stress in Carioca high- and low-conditioned freezing rats

Cited by 10 publications

References 101 publications

Non-human contributions to personality neuroscience – from fish through primates. An introduction to the special issue

Non-human contributions to personality neuroscience – from fish through primates. An introduction to the special issue

Pharmacological and Physiological Correlates of the Bidirectional Fear Phenotype of the Carioca Rats and Other Bidirectionally Selected Lines

Tracking puppy development: automated analysis and qualitative behavioral assessment in repeated open field tests

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