Behavioral effects of nicotine, amphetamine and cocaine under a fixed-interval schedule of food reinforcement in rats chronically exposed to caffeine

Jaszyna, Maria; Gąsior, Maciej; Shoaib, Mohammed; Yaşar, Sevil; Goldberg, Steven R.

doi:10.1007/s002130050766

Cited by 32 publications

(24 citation statements)

References 69 publications

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“…In further agreement with previous studies showing pharmacological specificity of tolerance to caffeine-induced motor activation (Holtzman and Finn, 1988) and to caffeine-induced increases in food-reinforced operant responding (Jaszyna et al, 1998), in the present study, there was no cross-tolerance to the motor-activating effects of amphetamine. Findings from previous studies also suggest that there are at least two different kinds of tolerance to some behavioral effects of caffeine (Finn and Holtzman, 1987;Holtzman and Finn, 1988).…”

supporting

confidence: 93%

“…Findings from previous studies also suggest that there are at least two different kinds of tolerance to some behavioral effects of caffeine (Finn and Holtzman, 1987;Holtzman and Finn, 1988). Tolerance to caffeine's motor-activating effects and stimulant effects on operant responding develops rapidly, is insurmountable, and is pharmacologically specific, showing cross-tolerance mostly to other methylxanthines, but not to other nonxanthine psychomotor stimulants (Finn and Holtzman, 1987;Katz and Goldberg, 1987;Holtzman and Finn, 1988;Jaszyna et al, 1998). On the other hand, tolerance is usually not seen to the rate-decreasing effects of high doses of caffeine on operant responding (Katz and Goldberg, 1987;Jaszyna et al, 1998).…”

mentioning

confidence: 93%

“…Tolerance to caffeine's motor-activating effects and stimulant effects on operant responding develops rapidly, is insurmountable, and is pharmacologically specific, showing cross-tolerance mostly to other methylxanthines, but not to other nonxanthine psychomotor stimulants (Finn and Holtzman, 1987;Katz and Goldberg, 1987;Holtzman and Finn, 1988;Jaszyna et al, 1998). On the other hand, tolerance is usually not seen to the rate-decreasing effects of high doses of caffeine on operant responding (Katz and Goldberg, 1987;Jaszyna et al, 1998). In experiments in which tolerance has been reported to the rate-decreasing effects of caffeine on food-reinforced operant responding and to its discriminative stimulus effects, tolerance develops gradually, is surmountable, and extends to many nonxanthine psychomotor stimulants (Holtzman and Finn, 1988).…”

mentioning

confidence: 99%

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Involvement of Adenosine A1 and A2A Receptors in the Motor Effects of Caffeine after its Acute and Chronic Administration

Karcz-Kubicha¹,

Αντωνίου²,

Terasmaa

et al. 2003

Neuropsychopharmacol

180

189

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The involvement of adenosine A 1 and A 2A receptors in the motor effects of caffeine is still a matter of debate. In the present study, counteraction of the motor-depressant effects of the selective A 1 receptor agonist CPA and the A 2A receptor agonist CGS 21680 by caffeine, the selective A 1 receptor antagonist CPT, and the A 2A receptor antagonist MSX-3 was compared. CPT and MSX-3 produced motor activation at the same doses that selectively counteracted motor depression induced by CPA and CGS 21680, respectively. Caffeine also counteracted motor depression induced by CPA and CGS 21680 at doses that produced motor activation. However, caffeine was less effective than CPT at counteracting CPA and even less effective than MSX-3 at counteracting CGS 21680. On the other hand, when administered alone in habituated animals, caffeine produced stronger motor activation than CPT or MSX-3. An additive effect on motor activation was obtained when CPT and MSX-3 were coadministered. Altogether, these results suggest that the motoractivating effects of acutely administered caffeine in rats involve the central blockade of both A 1 and A 2A receptors. Chronic exposure to caffeine in the drinking water (1.0 mg/ml) resulted in tolerance to the motor effects of an acute administration of caffeine, lack of tolerance to amphetamine, apparent tolerance to MSX-3 (shift to the left of its 'bell-shaped' dose-response curve), and true crosstolerance to CPT. The present results suggest that development of tolerance to the effects of A 1 receptor blockade might be mostly responsible for the tolerance to the motor-activating effects of caffeine and that the residual motor-activating effects of caffeine in tolerant individuals might be mostly because of A 2A receptor blockade.

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supporting

confidence: 93%

mentioning

confidence: 93%

mentioning

confidence: 99%

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Involvement of Adenosine A1 and A2A Receptors in the Motor Effects of Caffeine after its Acute and Chronic Administration

Karcz-Kubicha¹,

Αντωνίου²,

Terasmaa

et al. 2003

Neuropsychopharmacol

180

189

View full text Add to dashboard Cite

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“…The importance of adenosine in the modulation of actions of amphetamine is supported by recent findings of decreased behavioral effects of amphetamine in mice lacking A 2A adenosine receptors (Chen et al 2000), probably reflecting complex neuroadaptation processes in these transgenic animals. Finally, the nonselective adenosine antagonist caffeine potentiates the behavioral responses to amphetamine and cocaine in rats responding for food under a fixed-interval schedule of food reinforcement (Jaszyna et al 1998). Caffeine also has been found to potentiate the discriminativestimulus effects of amphetamine and cocaine and to mimic partially their discriminative-stimulus effects upon substitution (Schechter 1977;Gauvin et al 1990;Young et al 1998;reviewed by Garret and Griffiths 1997).…”

Section: Introductionmentioning

confidence: 96%

Adenosinergic modulation of the discriminative-stimulus effects of methamphetamine in rats

et al. 2002

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“…In animals, the effects of acute co-administration of caffeine and nicotine vary with previous nicotine exposure, 14 and chronic administration of caffeine does not affect nicotine discrimination. 17,19 In human studies, acute caffeine pretreatment does not increase smokers' ability to identify nicotine nasal spray as a stimulant or increase subjective reports of positive drug effects. 18,20 However, chronic caffeine consumption potentiated the positive, subjective effects of high doses of intravenously administered nicotine and reduced the subjective, negative effects of low doses in African American cocaine abusers.…”

mentioning

confidence: 99%

Relations Among Caffeine Consumption, Smoking, Smoking Urge, and Subjective Smoking Reinforcement in Daily Life

Treloar

Piasecki

McCarthy

et al. 2014

Journal of Caffeine Research

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Caffeine consumption and cigarette smoking tend to occur within the same individuals and at the same time. One potential explanation for this co-use is that caffeine consumption increases subjective smoking reinforcement. Electronic diaries were used to collect momentary reports of smoking, caffeine consumption, temptation/urge to smoke, and subjective smoking reinforcement in 74 prequit smokers. Momentary reports of caffeine consumption and smoking were associated, replicating previous findings. These results remained significant when contextual factors (time of day, weekday/weekend, presence of others, presence of others smoking, location, and past hour alcohol consumption) were covaried. Caffeine consumption was also associated with positive cigarette appraisals and reports of strong temptation/urge to smoke and urge reduction from the prior cigarette. Under the conditions of caffeine consumption versus at other times, smokers were significantly more likely to report their last cigarette as producing a rush/buzz, being pleasant, relaxing, and tasting good. The effects for temptation/urge to smoke and rush/buzz varied as a function of latency since smoking. Caffeine consumption increased reports of urge to smoke and rush/buzz only when smoking occurred more than 15 minutes prior to the diary entry. Findings suggest that caffeine consumption influences some aspects of smoking motivation or affects memorial processing of smoking reinforcement.

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Behavioral effects of nicotine, amphetamine and cocaine under a fixed-interval schedule of food reinforcement in rats chronically exposed to caffeine

Cited by 32 publications

References 69 publications

Involvement of Adenosine A1 and A2A Receptors in the Motor Effects of Caffeine after its Acute and Chronic Administration

Involvement of Adenosine A1 and A2A Receptors in the Motor Effects of Caffeine after its Acute and Chronic Administration

Adenosinergic modulation of the discriminative-stimulus effects of methamphetamine in rats

Relations Among Caffeine Consumption, Smoking, Smoking Urge, and Subjective Smoking Reinforcement in Daily Life

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