Behavioral effects of novel enterosorbent Noolit on mice with mixed depression/anxiety-like state

Borodin, Ju.I.; Kudryavtseva, N. N.; Тендитник, М. В.; Rachkovskaya, L. N.; Shurlygina, A. V.; Труфакин, В. А.

doi:10.1016/s0091-3057(01)00735-3

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…In our previous study, a lithium-based enterosorbent called "Noolit" had obvious anxiolytic and antidepressant effects in adult defeated male mice [23]. In the present study, we provide experimental data on the impact of chronic treatment with lithium chloride (LiCl) on the anxiety-like state caused by chronic social defeat stress that leads to a mixed anxiety/depression-like state in male mice [24][25][26].…”

Section: Introductionmentioning

confidence: 95%

Chronic Lithium Treatment Affects Anxious Behaviors and theExpression of Serotonergic Genes in Midbrain Raphe Nuclei of Defeated Male Mice

et al. 2021

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There is experimental evidence that chronic social defeat stress is accompanied by the development of an anxiety, development of a depression-like state, and downregulation of serotonergic genes in midbrain raphe nuclei of male mice. Our study was aimed at investigating the effects of chronic lithium chloride (LiCl) administration on anxiety behavior and the expression of serotonergic genes in midbrain raphe nuclei of the affected mice. A pronounced anxiety-like state in male mice was induced by chronic social defeat stress in daily agonistic interactions. After 6 days of this stress, defeated mice were chronically treated with saline or LiCl (100 mg/kg, i.p., 2 weeks) during the continuing agonistic interactions. Anxiety was assessed by behavioral tests. RT-PCR was used to determine Tph2, Htr1a, Htr5b, and Slc6a4 mRNA expression. The results revealed anxiolytic-like effects of LiCl on social communication in the partition test and anxiogenic-like effects in both elevated plus-maze and social interaction tests. Chronic LiCl treatment upregulated serotonergic genes in midbrain raphe nuclei. Thus, LiCl effects depend on the treatment mode, psycho-emotional state of the animal, and experimental context (tests). It is assumed that increased expression of serotonergic genes is accompanied by serotonergic system activation and, as a side effect, by higher anxiety.

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Section: Introductionmentioning

confidence: 95%

Chronic Lithium Treatment Affects Anxious Behaviors and theExpression of Serotonergic Genes in Midbrain Raphe Nuclei of Defeated Male Mice

et al. 2021

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“…Regular administration of lithium increases the density of the serotonin uptake site in cortical regions suggesting an increase in the number of serotonin transporters in the brain regions containing nerve terminals of serotonergic neurons [34]. In our study the behavioral effects of lithium-based enterosorbent, called ‘Noolit’, on male mice with mixed depression/anxiety-like state produced obvious anxiolytic and antidepressant effects [35].…”

Section: Introductionmentioning

confidence: 97%

Effects of chronic lithium treatment on anxious behaviors and serotonergic genes expression in the midbrain raphe nuclei in defeated male mice

Smagin

Kovalenko

Galyamina

et al. 2021

Preprint

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There are experimental data that mixed anxiety/depression-like state induced by chronic social defeat stress is accompanied by development of anxiety and downregulation of serotonergic gene expression in the midbrain raphe nuclei of male mice. The paper aimed to study the effect of chronic lithium chloride (LiCl) on anxious behaviors and the expression of serotonergic genes (Tph2, Slc6a4, Htr1a, Htr5b) in the midbrain raphe nuclei of defeated mice. Slight anxiolytic effects of LiCl were found on the commucativeness in the partition test, and anxiogenic-like effects, estimated by the elevated plus-maze and social interactions tests. Chronic LiCl treatment induced overexpression of the serotonergic genes in the midbrain raphe nuclei of defeated mice. We can assume that effects of LiCl, rather anxiogenic, may be due to activation of serotonergic system induced by hyperexpression of serotonergic genes. Our findings will allow to understand the factors involved in the positive and side effects of lithium on anxiety and function of serotonergic genes which are involved into mechanisms of depression.

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“…In our studies, eight criteria used were thought to point to the formation of behavioral pathology (Box) [3]. The most extensive studies have been conducted and the most satisfactory validating results obtained on mice for anxious depression, generalized anxiety, pathological aggression and psychogenic immune deficiency [3][4][5][6][7]. Generating different psychoemotional and psychosomatic disturbances in animals under the sensory contact model gives the opportunity to investigate the action of novel (along with widely used) psychotropic drugs and conduct their screening in the simulated clinical conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Anxiolytic effects of lithium-based enterosorbent Noolit (Fig. 1b,c) [5] and antidepressive effect of fluoxetine ( Fig. 1d) [Kovalenko et al, unpublished data] used in clinics [8] were shown in depressive mice after medicative (therapeutic) treatment.…”

Section: Introductionmentioning

confidence: 99%

Application of the Sensory Contact Model for Pharmacological Studies under Simulated Clinical Conditions

et al. 2007

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The sensory contact model allows forming different psychopathological states (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, addictive states etc.) produced by repeated agonistic interactions in male mice and investigating the therapeutic and preventive properties of any drug as well as its efficiency under simulated clinical conditions. This approach can be useful for a better understanding of the drugs' action in different stages of disease development in individuals. It is suggested that this behavioral approach and pharmacological designs may be applied for the screening of novel psychotropic drugs * .

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Behavioral effects of novel enterosorbent Noolit on mice with mixed depression/anxiety-like state

Cited by 8 publications

References 36 publications

Chronic Lithium Treatment Affects Anxious Behaviors and theExpression of Serotonergic Genes in Midbrain Raphe Nuclei of Defeated Male Mice

Chronic Lithium Treatment Affects Anxious Behaviors and theExpression of Serotonergic Genes in Midbrain Raphe Nuclei of Defeated Male Mice

Effects of chronic lithium treatment on anxious behaviors and serotonergic genes expression in the midbrain raphe nuclei in defeated male mice

Application of the Sensory Contact Model for Pharmacological Studies under Simulated Clinical Conditions

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