Behavioral effects of perinatal opioid exposure

Fodor, Anna; Tı́már, József; Zelena, Dóra

doi:10.1016/j.lfs.2014.04.006

Cited by 49 publications

(37 citation statements)

References 111 publications

(136 reference statements)

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“…Opioid pain medications disrupt endocrine system and HPA axis function. 3,28,32 Prenatal exposure to opioids is associated with negative behavioral and cognitive outcomes for offspring, in both human and animal studies, 34,45,106 and changes in analgesia in animals, 138 suggesting opioid exposure might lead to changes in a child’s pain processing system; note that the majority of human research in this area has focused on prenatal opioid exposure among offspring of mothers addicted to opioids. 45 Antiepileptic medications also carry increased risk of congenital abnormalities, preterm delivery, and low birth weight.…”

Section: Potential Mechanisms For the Transmission Of Riskmentioning

confidence: 99%

“…3,28,32 Prenatal exposure to opioids is associated with negative behavioral and cognitive outcomes for offspring, in both human and animal studies, 34,45,106 and changes in analgesia in animals, 138 suggesting opioid exposure might lead to changes in a child’s pain processing system; note that the majority of human research in this area has focused on prenatal opioid exposure among offspring of mothers addicted to opioids. 45 Antiepileptic medications also carry increased risk of congenital abnormalities, preterm delivery, and low birth weight. 6,46,147 A meta-analysis showed that antidepressant use during pregnancy is related to increased risk for low birth weight and low Apgar scores 116 and is associated with increased anxiety in offspring at 3 years of age.…”

Section: Potential Mechanisms For the Transmission Of Riskmentioning

confidence: 99%

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Transmission of risk from parents with chronic pain to offspring: an integrative conceptual model

Stone

Wilson

2016

Pain

127

135

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Offspring of parents with chronic pain are at increased risk for pain and adverse mental and physical health outcomes (Higgins et al, 2015). Although the association between chronic pain in parents and offspring has been established, few studies have addressed why or how this relation occurs. Identifying mechanisms for the transmission of risk that leads to the development of chronic pain in offspring is important for developing preventive interventions targeted to decrease risk for chronic pain and related outcomes (eg, disability and internalizing symptoms). This review presents a conceptual model for the intergenerational transmission of chronic pain from parents to offspring with the goal of setting an agenda for future research and the development of preventive interventions. Our proposed model highlights 5 potential mechanisms for the relation between parental chronic pain and pediatric chronic pain and related adverse outcomes: (1) genetics, (2) alterations in early neurobiological development, (3) pain-specific social learning, (4), general parenting and family health, and (5) exposure to stressful environment. In addition, the model presents 3 potential moderators for the relation between parent and child chronic pain: (1) the presence of chronic pain in a second parent, (2) timing, course, and location of parental chronic pain, and (3) offspring’s characteristics (ie, sex, developmental stage, race or ethnicity, and temperament). Such a framework highlights chronic pain as inherently familial and intergenerational, opening up avenues for new models of intervention and prevention that can be family centered and include at-risk children.

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Section: Potential Mechanisms For the Transmission Of Riskmentioning

confidence: 99%

Section: Potential Mechanisms For the Transmission Of Riskmentioning

confidence: 99%

Transmission of risk from parents with chronic pain to offspring: an integrative conceptual model

Stone

Wilson

2016

Pain

127

135

View full text Add to dashboard Cite

show abstract

“…A vast body of preclinical research indicates that different drugs affect negatively maternal care; this has been demonstrated for alcohol (18), cocaine (19), opioids (20), and ecstasy (21). Similarly, human studies strongly demonstrate that substance use disorders (SUDs) are clinical conditions that are able to interfere with relational competences (22) and parenting (23–27), affecting the establishment of the bond with the infant, with repercussions for his/her future affective-relational development.…”

Section: Introductionmentioning

confidence: 99%

Attachment Theory and Maternal Drug Addiction: The Contribution to Parenting Interventions

Parolin

Simonelli

2016

Front. Psychiatry

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Children’s emotional and relational development can be negatively influenced by maternal substance abuse, particularly through a dysfunctional caregiving environment. Attachment Theory offers a privileged framework to analyze how drug addiction can affect the quality of adult attachment style, parenting attitudes and behaviors toward the child, and how it can have a detrimental effect on the co-construction of the attachment bond by the mother and the infant. Several studies, as a matter of fact, have identified a prevalence of insecure patterns among drug-abusing mothers and their children. Many interventions for mothers with Substance Use Disorders have focused on enhancing parental skills, but they have often overlooked the emotional and relational features of the mother–infant bond. Instead, in recent years, a number of protocols have been developed in order to strengthen the relationship between drug-abusing mothers and their children, drawing lessons from Attachment Theory. The present study reviews the literature on the adult and infant attachment style in the context of drug addiction, describing currently available treatment programs that address parenting and specifically focus on the mother–infant bond, relying on Attachment Theory.

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“…Pain management for pregnant women can be challenging given potential fetal adverse effects. There is growing evidence that maternal distress may lead to various behavioral disorders and complex diseases in later life [21]. Concomitantly, analgesic medications may be harmful to the fetus [21].…”

Section: Discussionmentioning

confidence: 99%

“…There is growing evidence that maternal distress may lead to various behavioral disorders and complex diseases in later life [21]. Concomitantly, analgesic medications may be harmful to the fetus [21]. Acetaminophen (APAP) is often recommended for analgesia during all trimesters of pregnancy and is generally considered safe due to its widespread use and paucity of documented adverse effects [22,23].…”

Section: Discussionmentioning

confidence: 99%

Transient Osteoporosis of Pregnancy of the Bilateral Hips in Twin Gestation: A Case Series

Reese

Fitzgerald

Hynes

2014

PM&R

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Transient osteoporosis of pregnancy has been described as a rare, self-limiting disease of unclear etiology that presents as severe pain, which typically affects pregnant women in their third trimester. We describe 3 cases of primigravid pregnant women with twin gestation who reported unilateral hip pain and who were diagnosed with transient osteoporosis of pregnancy of the hip by magnetic resonance imaging. These women were advised to undergo limited weight bearing and activity modification to minimize the risk of fracture. Each patient was able to proceed through her pregnancy, delivery, and postpartum course without complication, with symptom resolution, and return to unrestricted activity.

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Behavioral effects of perinatal opioid exposure

Cited by 49 publications

References 111 publications

Transmission of risk from parents with chronic pain to offspring: an integrative conceptual model

Transmission of risk from parents with chronic pain to offspring: an integrative conceptual model

Attachment Theory and Maternal Drug Addiction: The Contribution to Parenting Interventions

Transient Osteoporosis of Pregnancy of the Bilateral Hips in Twin Gestation: A Case Series

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