Behavioral effects of peripheral interleukin-1 administration in adult CD-1 mice: specific inhibition of the offensive components of intermale agonistic behavior

Cirulli, Francesca; Acetis, Luigi De; Alleva, Enrico

doi:10.1016/s0006-8993(98)00137-1

Cited by 39 publications

(19 citation statements)

References 19 publications

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“…This is in contrast to the findings in mice with CIA, a model of inflammatory arthritis, in which a significant decrease in grooming was observed (14). A lack of grooming is thought to represent sickness behavior due to systemic cytokine release (22). This suggests that with the OA model, the observed differences in activity/behavior are due to local, joint-specific disability rather than systemic illness.…”

Section: Discussioncontrasting

confidence: 82%

Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system

Inglis

McNamee

Chia

et al. 2008

Arthritis & Rheumatism

107

126

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Objective. OA is the most common joint disease, affecting 10-15% of people over 60 years of age. However, up to 40% of individuals with radiologic damage are asymptomatic. The purpose of this study was to assess the role of the endogenous opioid system in delaying the onset of pain in a murine model of osteoarthritis (OA).Methods. Osteoarthritis was induced by transection of the medial meniscotibial ligament. Pain was assessed by monitoring weight distribution and activity. At various times postsurgery, the opioid receptor antagonists naloxone or peripherally restricted naloxone methiodide were administered, and pain was assessed. Levels of the -opioid receptor were assessed in the nerves innervating the joint by real-time reverse transcription-polymerase chain reaction analysis.Results. As in human disease, significant joint damage occurred in mice before the onset of pain. To assess whether delayed pain was partly the result of increased endogenous opioid function, naloxone or naloxone methiodide was administered. Both opioid receptor antagonists led to pain onset 4 weeks earlier than in vehicle-treated mice, indicating a role of the peripheral opioid system in masking OA pain. The expression of the -opioid receptor in the peripheral nerves supplying the joint was transiently increased in naloxoneresponsive mice. Conclusion.These findings indicate that a temporal induction of -opioid receptors in the early stages of OA delays the onset of pain. This is of clinical relevance and may contribute to the assessment of patients presenting with pain late in the disease. Furthermore, it may point to a mechanism by which the body blocks pain perception in moderate states of tissue damage, allowing an increased chance of survival.

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Section: Discussioncontrasting

confidence: 82%

Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system

Inglis

McNamee

Chia

et al. 2008

Arthritis & Rheumatism

107

126

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“…The results revealed a drop in non-social exploration similar to that observed by other authors studying exploratory behavior in response to a new environment after the central or peripheral (Cirulli et al, 1998;Dunn, 1992;Spadaro & Dunn, 1990) administration of LPS, IL-1 , or IL-1 . However, has been postulated that sickness behavior should also be considered as the expression of an organized strategy that is vital for the survival of the organism; in this case, the sick individual will be capable of reorganizing his/her behavior depending on the consequences and internal and external circumstances to which he/she is exposed.…”

Section: The Neurochemical and Behavioral Effects Produced By Melanomsupporting

confidence: 87%

“…Few studies have focused on the behavioral and neurochemical effects produced by the activation of the immune system in situations of social stress. Cirulli et al (Cirulli et al, 1998) found modifications in the agonistic behavior of young mice exposed to situations of conflict with adult mice following the peripheral administration of IL-1. We have studied the behavioral and neurochemical effects produced during the early phases of melanoma tumor development, under the most natural circumstances possible, i.e.. territorial aggression between male mice of the same species.…”

Section: The Neurochemical and Behavioral Effects Produced By Melanommentioning

confidence: 99%

“…This is similar to the way in which Zalcman et al (Zalcman et al, 1998) interpret the behavioral activation observed in mice after the administration of IL-2 and IL-6. In the context of aggressive confrontation between rodents after the administration of IL-1, Cirulli et al (Cirulli et al, 1998) observed a decrease in the aggressive components of agonistic behavior, although defensive elements such as upright submissive posture, crouching, or fleeing were not affected. Nevertheless, we should bear in mind that in our study, we observed a passive defensive behavior: avoidance.…”

Section: The Neurochemical and Behavioral Effects Produced By Melanommentioning

confidence: 99%

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Effects of Social Stress on Immunomodulation and Tumor Development

Vegas¹,

Garmendia²,

Arregi³

et al. 2011

Advances in Malignant Melanoma - Clinical and Research Perspectives

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“…Less predictably, a significant reduction in the amount of time spent grooming was detected in arthritic animals. A lack of grooming is thought to represent sickness behavior, because peripheral IL-1␤ administration to mice reduced the amount of grooming behavior (24). Because CIA is a systemic disease, an increase in cytokine levels and cachexia is likely.…”

Section: Discussionmentioning

confidence: 99%

Collagen‐induced arthritis as a model of hyperalgesia: Functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade

Inglis¹,

Notley²,

Essex³

et al. 2007

Arthritis & Rheumatism

156

155

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Objective. There is a disparity in the animal models used to study pain in rheumatoid arthritis (RA), which tends to be acute in nature, and models used to assess the pathogenesis of RA. The latter models, like human RA, are lymphocyte-driven and polyarthritic. We assessed pain behavior and mechanisms in collageninduced arthritis (CIA), the model of preclinical arthritis used most commonly in the field of immunology. We then validated the model using anti-tumor necrosis factor (anti-TNF) therapy, which has analgesic effects in models of inflammation as well as in human RA.Methods. CIA was induced in DBA/1 mice by immunization with type II collagen at the base of the tail. Swelling and mechanical and thermal hyperalgesia were assessed before and for 28 days after the onset of arthritis. Spontaneous behavior was assessed using an automated activity monitor. Glial activity was assessed by glial fibrillary acidic protein expression, and nerve damage was evaluated by activating transcription factor 3 expression. The actions of anti-TNF therapy on nociception were then evaluated.Results. Arthritis resulted in a decrease in the threshold for thermal and mechanical stimuli, beginning on the day of onset. Decreased spontaneous activity was also observed. A significant increase in the number of hyperplasic spinal cord astrocytes was observed beginning 10 days after the onset of arthritis. Anti-TNF therapy was profoundly analgesic, with an efficacy similar to that of cyclooxygenase 2 inhibition, and reduced astrocyte activity in CIA.Conclusion. This study shows that the CIA model is suitable for testing not only antiinflammatory but also analgesic drugs for potential use in RA, and highlights the importance of using appropriate disease models to assess relevant pain pathways.

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Behavioral effects of peripheral interleukin-1 administration in adult CD-1 mice: specific inhibition of the offensive components of intermale agonistic behavior

Cited by 39 publications

References 19 publications

Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system

Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system

Effects of Social Stress on Immunomodulation and Tumor Development

Collagen‐induced arthritis as a model of hyperalgesia: Functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade

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