Behavioral Effects of Psychomotor Stimulant Infusions into Amygdaloid Nuclei

O’Dell, Laura E.; Sussman, Amy; Meyer, Kym L; Neisewander, Janet L.

doi:10.1016/s0893-133x(98)00083-9

Cited by 37 publications

(23 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with this idea, BLA lesions do not disrupt responding for water or access to an estrous female on a continuous reinforcement schedule Everitt et al, 1989). Furthermore, intra-BLA infusion of D-amphetamine does not elicit conditioned place preference (O'Dell et al, 1999). These findings mitigate against the possibility that Damphetamine served simply as a drug prime in the present study, in addition to the already noted fact that intra-BLA infusions of D-amphetamine did not alter responding under extinction conditions.…”

Section: Discussionsupporting

confidence: 87%

Potentiated Reinstatement of Cocaine-Seeking Behavior Following D-amphetamine Infusion into the Basolateral Amygdala

Ledford

Fuchs

See

2003

Neuropsychopharmacol

View full text Add to dashboard Cite

Reinstatement of extinguished drug-seeking behavior following chronic drug self-administration has been demonstrated in rats in the presence of conditioned cues. This experimental model of cue-induced relapse can be used to assess the neural circuitry involved in relapse. We have previously shown that blockade of dopamine D1 receptors in the basolateral amygdala (BLA) abolishes conditioned cue-induced reinstatement of cocaine-seeking behavior. The present study tested the hypothesis that D-amphetamine-induced facilitation of monoamine neurotransmission in the BLA would potentiate conditioned cue-induced reinstatement of extinguished drug-seeking behavior. During daily self-administration sessions over 10 consecutive days, rats pressed a lever to receive cocaine infusions (0.2 mg/ 0.05 ml) paired with a light+tone compound stimulus. Following self-administration, rats underwent daily extinction sessions, during which no stimuli were presented. On the test days, rats received intra-BLA D-amphetamine (10 or 30 mg/side) or vehicle infusions followed by extinction or conditioned cue-induced reinstatement testing. D-amphetamine infusions did not alter extinction responding relative to vehicle infusions. During reinstatement testing, conditioned cue presentation significantly increased responding over extinction levels, and intra-BLA D-amphetamine produced a dose-dependent increase in lever responding relative to vehicle infusions. These findings suggest that enhanced monoamine tone in the BLA potentiates the motivational effect and/or salience of cocaine-paired cues during reinstatement.

show abstract

Section: Discussionsupporting

confidence: 87%

Potentiated Reinstatement of Cocaine-Seeking Behavior Following D-amphetamine Infusion into the Basolateral Amygdala

Ledford

Fuchs

See

2003

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…The CEA, on the other hand, shows increased neuronal activity following self-stimulation of the medial forebrain bundle (Hunt and McGregor, 1998), the classic definition of brain reward. Also, infusion of amphetamine into the CEA, but not the BLA, supports conditioned place preference (O'Dell et al, 1999). Finally, cocaine itself, as opposed to cocaine cues, activates immediate early gene expression in the CEA, but not in the BLA (Neisewander et al, 2000;Ciccocioppo et al, 2001).…”

Section: Introductionmentioning

confidence: 73%

Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Alleweireldt

Hobbs

Taylor

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

Amygdala D1 receptors have been implicated in the motivating effects of cocaine-conditioned cues and cocaine itself, but the specific nucleus involved is unclear. Thus, we infused the D1 antagonist, SCH-23390, into the rostral basolateral amygdala (rBLA), caudal basolateral amygdala (cBLA), or central amygdala (CEA), and tested its effects on self-administration of cocaine, as well as reinstatement of extinguished cocaine-seeking behavior by cocaine-conditioned cues or cocaine itself. Two anatomical controls, the posterior regions of basal ganglia (BG) and somatosensory/insular cortices (CTX), were also examined. Cocaine self-administration was increased and cue and cocaine reinstatement were decreased by SCH-23390 infusion into every region when examined across the hour test session, with the exception that cBLA infusion did not alter cocaine reinstatement. In the first 20 min of the session, when SCH-23390 was more localized in the target sites, self-administration was increased by infusion into the CEA, cBLA, BG, and CTX, with lesser increases in the rBLA. Cocaine reinstatement was attenuated during the first 20 min only by infusion into the CEA, rBLA, and CTX. Cue reinstatement was not reliably observed in the first 20 min, but there was a trend for attenuation by infusion into the cBLA, and surprisingly, significant attenuations in the BG and CTX. The findings suggest that D1 receptors in subregions of the amygdala play differential roles in the reinforcing/motivational effects of cocaine, while the cue reinstatement effects are less clear. Further research is needed to examine the novel findings that neighboring regions of the BG and CTX may play a role in motivation for cocaine.

show abstract

“…Specific lesions of the basolateral nucleus (BLA) decreased sucrose-produced place conditioning (Everitt et al 1991) and decreased the ability of a stimulus predictive of reward to elicit approach behavior (Burns et al 1993). Intra-amygdaloid infusions of amphetamine, and to a lesser extent, cocaine, supported the development of a conditioned place preference (O'Dell et al 1999), although these effects were manifest to a greater extent when the infusions were restricted to the central nucleus. Of particular relevance to the development of sensitization, infusions of amphetamine into the basolateral nucleus potentiated the subsequent development of reward/stimulus associations and facilitated the acquisition of discriminative approach behavior (Hitchcott et al 1997).…”

Section: Discussionmentioning

confidence: 92%

Effects of the Kappa-opioid Receptor Agonist, U69593, on the Development of Sensitization and on the Maintenance of Cocaine Self-administration

Schenk

2001

Neuropsychopharmacology

View full text Add to dashboard Cite

Previous studies showed that prior administration of kappa-opioid agonists decreased the development of sensitization to some of the behavioral effects of cocaine. The present study sought to determine whether the development of sensitization to cocaine's reinforcing effects was alsoFollowing repeated exposure to cocaine and other stimulants, the behavioral and neurochemical responses to subsequent exposures increase. This sensitized response has been suggested to contribute to the development of compulsive drug-taking that characterizes abuse and to the maintenance of self-administration via the strengthening of stimulus/reward associations (Robinson and Berridge 1993;Shippenberg and Heidbreder 1995). If so, treatments that prevent or attenuate the development of sensitization might be effective adjuncts to the treatment of cocaine addiction.Preclinical studies have demonstrated the impor- NO . 4 tance of the mesocorticolimbic dopamine system in the maintenance of cocaine self-administration. For example, destruction of the ascending dopamine pathways via 6-hydroxydopamine (Roberts et al. 1977) or pretreatment with dopamine antagonists (Caine and Koob 1994;De Wit and Wise 1977) attenuated cocaine selfadministration and shifted the dose-effect curve for cocaine self-administration to the right (Caine and Koob 1994;Schenk et al. 1999). In addition, cocaine has been shown to be self-administered directly into the medial prefrontal cortex (Goeders and Smith 1983) the projection site of the mesocortical dopamine system.Recent studies have shown that dopamine release is modulated by manipulations of kappa-opioid receptor systems. For example, pretreatment with kappa-opioid receptor agonists inhibited basal DA release in the NAC (Devine et al. 1993;Shippenberg et al. 1994;Spanagel et al. 1992) whereas administration of a k-opioid receptor antagonist increased basal dopamine release (Spanagel et al. 1992). Manipulations of kappa-opioid receptor systems also affect many of the behavioral responses to cocaine. Pretreatment with kappa-opioid receptor agonists attenuated the discriminative stimulus properties (Riberdy et al. 1995; Bergman 1992, 1994), conditioned reinforcing effects (Crawford et al. 1995), and self-administration (Glick et al. 1995;Mello and Negus 1998;Negus et al. 1997;Schenk et al. 1999) of cocaine. Further, in an animal model of relapse, U69593 pretreatment attenuated the ability of an experimenter-delivered priming injection of cocaine to reinstate extinguished cocaine-taking behavior (Schenk et al. 1999).Kappa-opioid agonists also attenuate the sensitized responses that occur following repeated exposure to cocaine and other stimulants. When administered repeatedly with cocaine, the kappa-opioid agonists U50488 or U69593 prevented the cocaine-produced increase in the response of the mesolimbic dopamine system to subsequent cocaine exposures (Heidbreder et al. 1996(Heidbreder et al. , 1998 and attenuated the ability of cocaine preexposure to sensitize rats to the conditioned reinforcing and locomoto...

show abstract

Behavioral Effects of Psychomotor Stimulant Infusions into Amygdaloid Nuclei

Abstract: The role of amygdaloid nuclei in locomotion, stereotypy, and conditioned place preference (CPP)

Cited by 37 publications

References 38 publications

Potentiated Reinstatement of Cocaine-Seeking Behavior Following D-amphetamine Infusion into the Basolateral Amygdala

Potentiated Reinstatement of Cocaine-Seeking Behavior Following D-amphetamine Infusion into the Basolateral Amygdala

Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Effects of the Kappa-opioid Receptor Agonist, U69593, on the Development of Sensitization and on the Maintenance of Cocaine Self-administration

Contact Info

Product

Resources

About