Behavioral estimates of absolute threshold in rat

Tedo, Carmen Musioz; Tejada, Pilar; Green, Daniel G.

doi:10.1017/s0952523800006891

Cited by 16 publications

(4 citation statements)

References 19 publications

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“…To measure absolute threshold, a slightly modified version of a procedure developed by Munoz Tedo et al (1994) was used. Accordingly, a dark-adapted rat was presented with a 2.5-s test light of preset intensity so that the light was somewhere above or below threshold.…”

Section: Seeing the Test Lightmentioning

confidence: 99%

“…The absolute visual sensitivity of rat (e.g. Kurylo et al, 1991;Munoz Tedo et al, 1994) has been studied extensively, but surprisingly little has been published on the increment sensitivity (but see Jacobs & Birch, 1975). Another goal is to determine key parameters of the b-wave and relate these to the behaviorally measured increment threshold response.…”

Section: Introductionmentioning

confidence: 99%

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Absolute and relative sensitivity of the scotopic system of rat: Electroretinography and behavior

et al. 2001

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The goal of the present study was to relate the dark and light-adapted flash sensitivity of the scotopic threshold response (STR) and rod b-wave of the electroretinogram (ERG) to behaviorally measured rod increment threshold responses. Small amplitudes of the dark-adapted STR and b-wave, the latter after application of NMDA, were found to increase in proportion to flash intensity. The value obtained for the sensitivity of the b-wave would be expected if signals from rods were summed linearly by the rod bipolar cell. The sensitivity of the STR could not be accounted for in terms of rod signal convergence as the source of this ERG component is still unknown. Increment threshold responses of rats were measured behaviorally in an operant conditioning chamber. At absolute threshold, on average I in 2400 rods were activated by the test flash. Comparison of the adaptive effects of background lights on behaviorally measured scotopic sensitivity and rod ERG sensitivity suggest that the increment threshold sensitivity of rat is regulated at three different sites in the retina.

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Section: Seeing the Test Lightmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Absolute and relative sensitivity of the scotopic system of rat: Electroretinography and behavior

et al. 2001

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“…Investigations of visual function in rats have focused on detection sensitivity and the neural mediation of form discrimination. Absolute thresholds in rats are comparable with those of humans (Birch & Jacobs, 1979;Kurylo, Hansen, & Fulton, 1991;Muntz, 1967;Rosenberger & Ernest, 1971;Tedo, Herreros de Tejada, & Green, 1994;Trejo & Cicerone, 1987), whereas acuity is much poorer (Dean, 1978(Dean, , 1981, with diminished contrast sensitivity that is restricted to low spatial frequencies (Birch & Jacobs, 1979;Legg, 1984). Rats are nevertheless capable of discriminating complex visual patterns (e.g., Lashley, 1930Lashley, , 1938.…”

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confidence: 95%

Characteristics of perceptual grouping in rats.

Kurylo

Nest²,

Knepper³

1997

Journal of Comparative Psychology

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Parametric analysis was made of the characteristics by which proximity and alignment serve as cues for perceptual grouping in rats. Rats were initially conditioned to discriminate a series of horizontal lines from vertical lines. Following training, rats were presented with test stimuli that consisted of bistable arrays of disjunct dots. A grouping cue (greater proximity, greater alignment, or both) was randomly assigned to either the horizontal or vertical orientation. The effectiveness of the cues was based on behavioral responses to the cued orientation. Results indicated that proximity served as a cue for perceptual grouping. The effectiveness of the proximity cue was less for rats than found previously in humans and, unlike humans, diminished with increased stimulus scale. Rats did not respond to alignment cues when used in isolation, although alignment facilitated grouping when used in conjunction with proximity cues. Diminished effectiveness of grouping cues likely reduces object recognition abilities, particularly for complex visual stimuli.

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“…12 Behavioral techniques have provided researchers with a second approach to assessing visual deficits in animals. 13 Many techniques, such as the visual water box method, require that animals recognize a visual cue to choose the proper pathway in a maze-like procedure.…”

Section: Introductionmentioning

confidence: 99%

Behavioral assessment of visual deficits in the taiep mutant

Bloom¹,

Post²,

Anch

et al. 2013

DNND

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Taiep (tremor, ataxia, immobility, epilepsy, paralysis) mutants show a significant increase in myelin thickness from 10 to 30 days of age but then demonstrate a decrease in myelin thickness from 1 to 6 months. The severity of the demyelination in the optic nerve suggests that visual deficits may exist in the taiep mutants. Animals were trained on a discrimination task, in which responses to a light stimulus (the S D period) were reinforced on a fixed ratio (FR)-1 schedule, and responses in the absence of the light stimulus (the S ∆ period) were not reinforced. Following training, the light intensity presented during the S D period was gradually reduced between sessions until −6.0 candela/m 2 was reached. Both groups of animals -taiep mutants and control Sprague Dawley rats -successfully recognized and responded in the presence of the stimulus near perfectly by the final day of training, suggesting that taiep mutants demonstrated normal learning, at least under this paradigm. Despite the severe demyelination of the taiep optic nerve, no visual deficits were detected as both groups of animals performed similarly as the light intensity decreased. Though the myelin loss of the optic nerve may have negatively affected signal transduction, this did not result in an increase in visual threshold.

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Behavioral estimates of absolute threshold in rat

Cited by 16 publications

References 19 publications

Absolute and relative sensitivity of the scotopic system of rat: Electroretinography and behavior

Absolute and relative sensitivity of the scotopic system of rat: Electroretinography and behavior

Characteristics of perceptual grouping in rats.

Behavioral assessment of visual deficits in the taiep mutant

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