Behavioral Impairment in Aquatic Organisms Exposed to Neurotoxic Pollutants

Abstract

Neuroactive chemicals are compounds that can modulate, at very low concentrations, the normal function of the central nervous systems of an organism through various primary modes of action (MoA) [...]

Assessing Environmental Risks during the Drug Development Process for Parasitic Vector-Borne Diseases: A Critical Reflection

“…Those exposure scenarios could expand over multiple generations, with partly unpredictable changes in responeses of test organisms among generations . These tests primarily focus on the toxic effects of chemicals, such as mortality, reproductive perturbations, and developmental impacts, such that we risk overlooking subtler (sometimes difficult to repeatably quantify) yet ecologically relevant effects, including changes in animal behavior. − Exposure to a wide range of chemicals, including drugs, has been shown to induce behavioral changes in diverse species, which can have far-reaching consequences for individual fitness and species interaction with consequences on ecosystem integrity …”