Behavioral Interventions in Mild Cognitive Impairment (MCI): Lessons from a Multicomponent Program

Levy, Shellie-Anne; Smith, Glenn E.; Wit, Liselotte De; DeFeis, Brittany; Ying, Gelan; Amofa, Priscilla; Locke, Dona E.C.; Shandera-Ochsner, Anne L.; McAlister, Courtney; Phatak, Vaishali S; Chandler, Melanie

doi:10.1007/s13311-022-01225-8

Cited by 14 publications

(5 citation statements)

References 60 publications

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“…Cognitive training, establishing proper sleep hygiene, managing potential depression, and improving quality of life are measures that can also alleviate MCI symptoms [84,85]. An important task is to identify other modifiable risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…According to the guidelines of the American Academy of Neurology (AAN), physical activity and exercise are primarily encouraged in MCI cases, in contrast to pharmacological therapy [ 84 ]. Cognitive training, establishing proper sleep hygiene, managing potential depression, and improving quality of life are measures that can also alleviate MCI symptoms [ 84 , 85 ]. An important task is to identify other modifiable risk factors.…”

Section: Discussionmentioning

confidence: 99%

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Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Fekete,

Lehoczki,

Major

et al. 2024

Nutrients

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Recent research exploring the relationship between the gut and the brain suggests that the condition of the gut microbiota can influence cognitive health. A well-balanced gut microbiota may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, and symbiotics are nutritional supplements and functional food components associated with gastrointestinal well-being. The bidirectional communication of the gut–brain axis is essential for maintaining homeostasis, with pre-, pro-, and symbiotics potentially affecting various cognitive functions such as attention, perception, and memory. Numerous studies have consistently shown that incorporating pre-, pro-, and symbiotics into a healthy diet can lead to improvements in cognitive functions and mood. Maintaining a healthy gut microbiota can support optimal cognitive function, which is crucial for disease prevention in our fast-paced, Westernized society. Our results indicate cognitive benefits in healthy older individuals with probiotic supplementation but not in healthy older individuals who have good and adequate levels of physical activity. Additionally, it appears that there are cognitive benefits in patients with mild cognitive impairment and Alzheimer’s disease, while mixed results seem to arise in younger and healthier individuals. However, it is important to acknowledge that individual responses may vary, and the use of these dietary supplements should be tailored to each individual’s unique health circumstances and needs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Fekete,

Lehoczki,

Major

et al. 2024

Nutrients

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“…Levy et al [22] summarize the results of various studies of behavioral intervention techniques for persons with mild cognitive impairment and their partners. These include, especially, the Healthy Action to Benefit Independence and Thinking (HABIT®) program, a behavioral intervention, which found that quality of life was most affected by inclusion of wellness education.…”

Section: Behavioral Interventions In Mild Cognitive Impairmentmentioning

confidence: 99%

The Broad Range of Research in Alzheimer's Disease and Related Dementias

DeKosky

Duara

2022

Neurotherapeutics

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“…While neurodegenerative forms of dementia are irreversible, non-pharmacological interventions (i.e., behavioral interventions such as physical exercise, note taking, social engagement, and computerized cognitive training) administered at an early stage (e.g., MCI) can preserve functional independence, slow cognitive decline, and thereby delay the onset of dementia ( Gauthier, 2005 ; Levy et al, 2022 ). A review by Chandler et al (2016) revealed the benefits of behavioral interventions in improving mood ( k = 26, Cohen’s d = 0.16, 95% CI = [0.03–0.28]), functional ability ( k = 31, d = 0.23, 95%CI = [0.16–0.47]), and metacognition ( k = 26, d = 0.30, 95%CI = [0.15–0.58]) in pwMCI ( Chandler et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

“…A few limitations were identified in existing systematic literature reviews and meta-analyses. First of all, while the effects of combined interventions have been extensively studied in the past decade (see Supplementary material A ), research has focused predominantly on comparative effectiveness analysis ( Amofa et al, 2021 ; Levy et al, 2022 ), a tool commonly used to explore the additive effect of a specific arm instead of changes an overall program has exerted. For example, Imaoka et al (2019) used comparative effective analysis to investigate the additive effect of soy peptide as a supplement to memory exercise in pwMCI but did not study the overall efficacy of both when compared to an untreated control group.…”

Section: Introductionmentioning

confidence: 99%

Multimodal cognitive and behavioral interventions for patients with MCI: a systematic review and meta-analysis on cognition and mood

Ying,

Perez-Lao,

Marsiske

et al. 2024

Front. Aging Neurosci.

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BackgroundResearch has increasingly suggested a benefit to combining multiple cognitive or behavioral strategies in a single treatment program for cognitively impaired older adults. Therefore, this systematic review and meta-analysis aimed to summarize results on the effects of multimodal cognitive and behavioral interventions versus control conditions on changes in cognition and mood in patients with mild cognitive impairment (pwMCI).MethodsThe review followed a general PRISMA guideline for systematic literature review with a format consisting of participants, interventions, comparators, and outcomes (PICO). Multilevel meta-analyses of aggregated efficacy were performed to assess the pooled effect sizes for cognitive and mood outcomes. Risk-of-bias, heterogeneity across studies, and publication bias were assessed for each outcome.ResultsAfter primary and reference searches, 18 studies with low or some concerns of risk of bias were included. Low heterogeneity was found for mood and cognition. Funnel plots did not indicate publication bias. All the studies assessed changes in cognition (n = 1,555) while seven studies with mood outcomes (n = 343) were included. Multilevel meta-analyses demonstrated moderate effect (Hedge’s g = 0.44, 95% CI = [0.21–0.67]) in cognitive outcomes and large effect in mood (g = 0.65, 95% CI = [0.37–0.93]). Subdomain analyses found low-moderate effects in global cognition, verbal and non-verbal memory, executive function, visuospatial abilities, and semantic fluency (0.20 < g < 0.50).ConclusionThese findings showed comparable to larger effects of multimodal cognitive and behavioral interventions on cognition than pharmacological treatment. Future studies should focus on the longitudinal effects of multimodal interventions in delaying dementia.Systematic review registration: PROSEPRO, CRD42022349297.

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Behavioral Interventions in Mild Cognitive Impairment (MCI): Lessons from a Multicomponent Program

Cited by 14 publications

References 60 publications

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

The Broad Range of Research in Alzheimer's Disease and Related Dementias

Multimodal cognitive and behavioral interventions for patients with MCI: a systematic review and meta-analysis on cognition and mood

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