Behavioral Management of Oral Medication Administration Difficulties among Children

Pelco, Lynn E.; Kissel, Robert; Parrish, John M.; Miltenberger, Raymond G.

doi:10.1097/00004703-198704000-00005

Cited by 19 publications

(16 citation statements)

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“…We restricted our search strategy to include articles that were published in English between December 1986, just before the last review, and December 2013. 4 Our population of interest included pediatric patients ages 0 to 21 with pill swallowing difficulty. We excluded articles that focused on children with a diagnosis of dysphagia or any other condition associated with swallowing dysfunction such as severe developmental disabilities.…”

Section: Data Sources and Search Strategymentioning

confidence: 99%

“…In 1987, Pelco et al 4 reviewed the relevant literature on interventions to address pill swallowing difficulties in children. The authors found 5 studies that used behavioral techniques such as instruction, modeling, positive and negative reinforcement, and shaping to help children swallow pills.…”

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confidence: 99%

“…The authors found 5 studies that used behavioral techniques such as instruction, modeling, positive and negative reinforcement, and shaping to help children swallow pills. [4][5][6][7][8][9] All studies reported routine pill acceptance shortly after their intervention, and 3 studies reported continued pill acceptance 3 to 6 months after the intervention. [4][5][6][7][8][9] Unfortunately, all studies mentioned in the review had small sample sizes, ranging from 1 to 6 children.…”

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confidence: 99%

“…[4][5][6][7][8][9] All studies reported routine pill acceptance shortly after their intervention, and 3 studies reported continued pill acceptance 3 to 6 months after the intervention. [4][5][6][7][8][9] Unfortunately, all studies mentioned in the review had small sample sizes, ranging from 1 to 6 children. [4][5][6][7][8][9] Thus, knowledge about the effectiveness of the tested interventions was limited.…”

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confidence: 99%

“…[4][5][6][7][8][9] Unfortunately, all studies mentioned in the review had small sample sizes, ranging from 1 to 6 children. [4][5][6][7][8][9] Thus, knowledge about the effectiveness of the tested interventions was limited.…”

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confidence: 99%

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Effectiveness of Pediatric Pill Swallowing Interventions: A Systematic Review

et al. 2015

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Effectiveness of Pediatric Pill Swallowing Interventions: A Systematic Review

et al. 2015

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Novel Oral Medication Delivery System for Famotidine

Schwartz

Yeh

Berger

et al. 1995

The Journal of Clinical Pharma

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A famotidine wafer that rapidly disperses on the tongue without water is a novel alternative to other histamine2 (H2)-antagonist dosage forms. Benefits associated with such a dosage form include convenience and potentially improved compliance for patients who dislike or have difficulty taking tablets and capsules. This report describes the research of three studies on the famotidine wafer dosage form. In the first trial, the bioequivalence and tolerability of the new 40-mg famotidine wafer and the marketed 40-mg famotidine tablet were studied in a 2-period crossover study (n = 18). The two formulations were bioequivalent as assessed by area under the plasma concentration versus time curve and maximum plasma concentration of famotidine. The plasma concentration of famotidine associated with 50% inhibition of pentagastrin stimulated gastric acid secretion (EC50; 10 ng/mL) was attained on average within 0.5 hours post-dose for the wafer and tablet. In a second trial, the tolerability of the famotidine 20-mg and 40-mg wafers or placebo given twice daily (bid) for 14 days were evaluated (n = 192). Both wafer strengths were well and equally tolerated. In a third trial of 450 subjects, the 40-mg wafer was preferred over tablets by 75% of the subjects, when they were asked to consider the method of administration and flavor. When used as an alternative to tablets and other conventional dosage forms, the wafers have the potential therapeutic benefit of improved compliance. It is concluded that similar systemic exposure, excellent tolerability, palatability, and preference make the famotidine wafer a clinically acceptable and convenient dosage from for patients on H2-antagonist therapy.

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Dysphagia—Ingestion or Deglutition?: A Proposed Paradigm

Leopold

Kagel

1997

Dysphagia

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The current classifications of dysphagia are based on local structural or central nervous system pathology causing dysfunction of the aerodigestive tract. The result is a clinical science grounded in the analysis of the swallow with its lingual, pharyngeal, and esophageal stages. Adding bolus preparation to the swallowing paradigm improves but still constrains the study of dysphagia and treatment of the dysphagic patient. Those pre-oral facets of mealtime behavior that may evoke or exacerbate dysphagia remain beyond the existing classification boundaries imposed by the conceptual swallow and anatomic aerodigestive tract. We offer a more inclusive strategy for investigating dysphagia based on a five-stage process of ingestion: pre-oral (anticipatory), preparatory, lingual, pharyngeal, and esophageal. The first stage considers the interaction of pre-oral motor, cognitive, psychosocial, and somataesthetic elements engendered by the meal. The limited literature regarding the interaction of the pre-oral stage with other ingestion stages, in both normal subjects and patients with cortical, basal ganglia, and psychogenic diseases, is reviewed. The neurophysiologic and clinical justifications for embracing a pre-oral stage, and thus for the paradigm shift from deglutition to ingestion, are presented.

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Behavioral Management of Oral Medication Administration Difficulties among Children

Cited by 19 publications

References 0 publications

Effectiveness of Pediatric Pill Swallowing Interventions: A Systematic Review

Effectiveness of Pediatric Pill Swallowing Interventions: A Systematic Review

Novel Oral Medication Delivery System for Famotidine

Dysphagia—Ingestion or Deglutition?: A Proposed Paradigm

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