Behavioral, Neurochemical, and Neuromorphological Effects of Deltamethrin in Adult Rats

Husain, Raushan; Vm, Adhami; Pk, Seth

doi:10.1080/009841096161212

Cited by 56 publications

(1 citation statement)

References 24 publications

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“…Deltamethrin [(R, S)] is a type-II pyrethroid synthetic insecticide, which has been widely used to control noxious insects in agriculture, forestry and horticulture. However, a number of studies have demonstrated genotoxic and tumorogenic effects of deltamethrin in mammalian and non-mammalian species [4,5]. For many pesticides, induction of oxidative stress is one of the main mechanisms of their action.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant properties of Pelargonium graveolens L’Her essential oil on the reproductive damage induced by deltamethrin in mice as compared to alpha-tocopherol

et al. 2013

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BackgroundExposure to the pyrethroid pesticide deltamethrin has been demonstrated to exert a wide range of effects on non-targeted organisms. The beneficial effects of geranuim essential oil (EO) as an antioxidant has been assessed in deltamethrin (DL) orally administered mice by studying whether the reprotoxicity caused by deltamethrin can be effectively combated with the geranium oil and the effects were compared to vitamin E, as the standard reference drug.ResultSixty male albino mice were divided into six equal groups: a control group, a group of mice was given deltamethrin (5 mg/kg b.w.), two groups were administered deltamethrin after having given geranium essential oil (67 mg/kg b.w.) or vitamin E (Vit E) (100 mg/kg b.w.), and two groups received only EO of geranium or Vit E. When compared to control, a dose of deltamethrin 5 mg/kg/day causes a decrease in the epididymal sperm count motility and viability and an increase in the number of abnormal morphology in spermatozoa. DL-exposed mice showed a significant increase of lipid peroxidation (LPP) in the testis compared to control animals.ConclusionEssential oil of geranium prevented testicular oxidative damage explored by reduced LPP and improved total sperm motility, viability and morphology in mice spermatozoa. Our study showed a positive influence of geranium essential oil in the animal male reproductive system similar than that of Vit E.

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Section: Introductionmentioning

confidence: 99%