1997
DOI: 10.1177/089198879701000206
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Behavioral Phenomenology in Alzheimer's Disease, Frontotemporal Dementia, and Late-Life Depression: A Retrospective Analysis

Abstract: Often patients in the early stages of Alzheimer's disease (AD), frontotemporal dementia (FTD), and late-life depression can be difficult to differentiate clinically. Although subtle cognitive distinctions exist between these disorders, noncognitive behavioral phenomenology may provide additional discriminating power. In 19 subjects with AD, 19 with FTD, 16 with late-life psychotic depression (LLPD), and 19 with late-life nonpsychotic depression (LLNPD), noncognitive behavioral symptoms were quantified retrospe… Show more

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Cited by 59 publications
(37 citation statements)
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“…It must be underlined that this is an open-label, randomized, uncontrolled study, with no crossover: these points decrease somehow the index of the evidence-based value of the observations, though our results confirm the previously reported and limited results from the literature [24, 25]and indicate that long-term paroxetine treatment is effective, in particular in behavior symptoms, and safe in this patient population. The results demonstrate that long-term treatment with paroxetine may influence noncognitive aspects of FTD: it ameliorates significantly personal behavior and social conduct, taking into account different parameters, measured by the different scales used.…”
Section: Discussionsupporting
confidence: 79%
See 1 more Smart Citation
“…It must be underlined that this is an open-label, randomized, uncontrolled study, with no crossover: these points decrease somehow the index of the evidence-based value of the observations, though our results confirm the previously reported and limited results from the literature [24, 25]and indicate that long-term paroxetine treatment is effective, in particular in behavior symptoms, and safe in this patient population. The results demonstrate that long-term treatment with paroxetine may influence noncognitive aspects of FTD: it ameliorates significantly personal behavior and social conduct, taking into account different parameters, measured by the different scales used.…”
Section: Discussionsupporting
confidence: 79%
“…Surprisingly, patients with FTD manifest troubles with anticholinesterase compounds, showing an increase in aggressiveness and agitation [1, 9, 23]. On the contrary, selective serotonin uptake inhibitors have been used with some success [24, 25]. …”
Section: Introductionmentioning
confidence: 99%
“…This method makes it possible to use the results of the present study for predictions on an individual level [35]. A similar design, with multivariate stepwise discriminant analysis to reduce the number of variables to the most effectively discriminating, has earlier been used [37] in a study comparing the behavioral phenomenology in AD, FTD and latelife depression. In the study a subset of 14 items that collectively best discriminated between the syndromes was deduced from the original set of 38 items.…”
Section: Discussionmentioning
confidence: 99%
“…FTLD is mainly considered as presenile dementia, which is featured by an age at onset before 65 years [1]. There are only a few smaller studies that have addressed the occurrence of psychiatric symptoms in FTLD [2][3][4][5]. None of them has used standardized psychopathologic assessment methods.…”
Section: Introductionmentioning
confidence: 99%