Background::
Lack of control in voluntary movements, resting tremor, postural instability,
and stiffness are the hallmarks of Parkinson's disease (PD).
Objective::
The current work's objective is to assess naringin isolated from Citrus aurantium L.
peels as an anti-parkinsonism agent in rats.
Methods::
The HPLC and LC-ESI-MS analysis of Citrus aurantium L. peels methanol extract was
done. The behavioral, biochemical, genetic, and histopathological analysis were evaluated in parkinsonism
rats.
Results::
Fourteen phenolics and nine flavonoids were found in the extract, according to the
HPLC analysis, while LC-ESI-MS analysis revealed the presence of twenty-six flavonoids. The
dominant flavonoid subclasses were 4 aglycones, 11 monoglycosides, 5 diglycosides, and 6
polymethoxy flavonoids, beside 4 coumarines, 4 alkaloids and a limonin triterpene. Adenosine
A2A receptor (A2AR) gene expression, malondialdehyde (MDA), interleukin-6 (IL-6), caspase-3
(Cas-3) and DNA fragmentation levels significantly increased in rotenone-treated rats. Dopamine
(DA), norepinephrine (NE), serotonin (5-HT), reduced glutathione (GSH), succinate, and lactate
dehydrogenase (SDH &LDH) levels all significantly decreased. Treatment with naringin and
A2AR antagonists enhanced the animals’ behavior and improved all the selected parameters. The
brain hippocampal features confirmed our results.
Conclusion::
Naringin could be considered a nutraceutical agent by attenuating the neurodegeneration
associated with PD via blocking adenosine A2AR.
conclusion:
Naringin could be considered as a nutraceutical agent by attenuating the neurodegeneration associated with PD via blocking adenosine A2AR