Behavioral, Virologic, and Immunologic Factors Associated With Acquisition and Severity of Primary Epstein–Barr Virus Infection in University Students

Abstract

Kissing was a significant risk for primary EBV infection. A total of 89% of infections were symptomatic, and blood viral load and CD8(+) lymphocytosis correlated with disease severity.

T Cells Modulate Epstein-Barr Virus Latency Phenotypes during Infection of Humanized Mice

“…By reducing the number of latency III cells, CD4 ϩ T cells may limit the activation of CD8 ϩ T cells, which is the major cause of infectious mononucleosis (IM) symptoms (47). CD4 ϩ T cells may also promote survival and proliferation of the latency I and IIa cells.…”

Cognate HLA absence in trans diminishes human NK cell education

“…Furthermore, donors were disparate for HLA-A2 expression, which allowed us to track the progeny of specific donors in mixed reconstitution lial malignancies through its viral oncogenes that are expressed during latent infection, lytic replication that produces infectious virions seems to be poorly controlled during IM and causes the characteristic immune pathogenic CD8 + T cell lymphocytosis of this disease (23). NK cells were reported to expand during IM (21,24,25) and seem to particularly restrict lytic EBV infection that is deregulated during IM (25,26). Interestingly, and in contrast to the prototypic terminally differentiated NK cell-expanding pathogen HCMV, EBV seems to drive the proliferation of early differentiated non-KIR-educated NK cells (25,27).…”

“…EBV persistently infects more than 90% of the human adult population (20). While primary infection is usually asymptomatic in children, adolescents more frequently suffer from infectious mononucleosis (IM) during their first encounter with EBV (21,22). While EBV is associated with B cell and epithe-NK cells are innate lymphocytes with protective functions against viral infections and tumor formation.…”

HLA-DQ β1 alleles associated with Epstein-Barr virus (EBV) infectivity and EBV gp42 binding to cells

“…Although the infection often presents with nonspecific or no symptoms in young children, EBV frequently causes infectious mononucleosis in young adults (1). EBV is associated with a number of malignancies, including Burkitt and Hodgkin lymphoma, nasopharyngeal carcinoma, and gastric carcinoma.…”