Behaviour of 2‐Indolecarbohydrazides in Sodium Ethoxide Solution

Abstract

Lehmann, Ghoneim und El-GendyArch. Pharm.Mean transit time values (Tsys) were calculated from the blood level curves given in Fig. lb. Tsys-values for each formulation are represented by vertical arrows below the time-axis and are determined to be as follows: 520 and 590min for tablet forms 1 and 2, and 847 and 905min for sustained release formulations 3 and 4.According to von Hattingberg and Brockmeie?) the additivity of mean times within a sequence of biopharmaceutical subsystems is expressed by a linear relationship of Tdiss.vitro and Tsys in the organism. Fig. 2 demonstrates the validity of this hypothesis. The intercept Tdiss-vitro = 0 would therefore represent the mean transit time of a metoclopramide solution. From the flat slope of the linear regression curve it can be seen, that the dissolution of the metoclopramide formulations is slower in-vivo than in-vitro. The results indicate excellent in-vitrolin-vivo correlation of the metoclopramide availability in all solid dosage forms investigated.

Chemistry and heterocyclization of carbohydrazides

“…Hydrazone 17 was formed when 2‐indole carbohydrazide 1 was dissolved in ethanol for 3 h at room temperature. On other hand, compound 17 was also obtained by condensing 1 with the aldehyde 18 [34]. …”