Behaviour of ChronOS™ Inject in metaphyseal bone defects of distal radius fractures: Tissue reaction after 6–15 months

Arora, Rohit; Milz, Stefan; Sprecher, Christoph M.; Sitte, Ingrid; Blauth, M.; Lutz, M.

doi:10.1016/j.injury.2012.06.006

Cited by 8 publications

(5 citation statements)

References 36 publications

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“…Despite the development of various natural or synthetic biomaterials for cartilage tissue engineering, the biological safety of scaffolds and the long-term biocompatibility between chondrocytes and scaffolds, or between tissue-engineered cartilage and acceptor tissue , still needs to be further investigated. Most of the currently used biodegradable material has been reported to cause certain inflammatory reactions, and in some cases, it is even rejected following implantation via immune reactions (21,22). Compared to other materials, APG is an autologous material with reduced immunogenicity and enhanced biocompatibility, and has been used in certain clinical cases.…”

Section: Discussionmentioning

confidence: 99%

The application of autologous platelet-rich plasma gel in cartilage regeneration

Xie

Nie

Shen

et al. 2014

Molecular Medicine Reports

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Cartilage defect caused by disease or trauma remains a challenge for surgeons, owning to the limited healing capacity of cartilage tissues. Cartilage tissue engineering provides a novel approach to address this issue, and appears promising for patients with cartilage defects. The cell scaffold, as one of the three key elements of tissue engineering, plays an important role in cartilage tissue engineering. Platelet‑rich plasma (PRP), which is a fraction of the plasma containing multiple growth factors, has become a major research focus in the context of its use as a bioactive scaffold for tissue engineering. Therefore, we investigated the value of using PRP scaffolds combined with chondrocytes in cartilage tissue engineering. In this study, we examined the levels of growth factors in PRP, and the effects of PRP on cell proliferation and matrix synthesis in rabbit chondrocytes cultured in PRP. Short-term in vitro culture followed by long‑term in vivo implantation was performed to evaluate the chondrogenesis of neocartilage in vivo. The results show that PRP may provide a suitable environment for the proliferation and maturation of chondrocytes, and can be used as a promising bioactive scaffold for cartilage regeneration.

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Section: Discussionmentioning

confidence: 99%

The application of autologous platelet-rich plasma gel in cartilage regeneration

Xie

Nie

Shen

et al. 2014

Molecular Medicine Reports

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“…Despite the extensive use of hydroxyapatite in skeletal‐tissue engineering their slow dissolution have always been a practical concern . Thus, more readily degradable calcium phosphate bioactive minerals like β‐tricalcium phosphate (β‐TCP) and biphasic calcium phosphate (BCP) (a mix of hydroxyapatite and β‐TCP) have been sought‐out to treat bone‐related injuries . Although previous attempts have examined β‐TCP hydrogel composites, much of the focus is centered on BCP ceramics, as it offers a balance between the properties of hydroxyapatite and β‐TCP .…”

Section: Mineral‐based Nanocomposite Hydrogels For Skeletal‐tissue Enmentioning

confidence: 99%

Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load‐Bearing and Electroactive Tissues

et al. 2016

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Graphene The addition of a protective diluent (e.g., pyrene) to graphite during ball-milling results in a game-changer yield (>90%) of defect-free graphene, as described in article number 1603528 by Matat Buzaglo, Oren Regev, and co-workers. In the non-protected milling, there is a continuous fragmentation leading to amorphous carbon formation, whereas in a diluent-protected milling, the diluent adsorbs part of the impact forces, enabling exfo-liation into graphene, whose size is controlled by the milling energy and the diluent type. A Supercritical Lens Optical Label-Free Microscopy: Sub-Diffraction Resolution and Ultra-Long Working Distance Optical Imaging A planar metalens for achieving super-resolution imaging in far-field is proposed. This metalens, which has a non-sub-wavelength feature size, can be fabricated by conventional laser pattern generator. The imaging process is purely physical and captured in real time, without any pre-and post-processing. A new member of the layered pseudo-1D material family-monoclinic gal-lium telluride (GaTe)-is synthesized by physical vapor transport on a variety of substrates. The [010] atomic chains and the resulting anisotropic behavior are clearly revealed. The GaTe flakes display multiple sharp photoluminescence emissions in the forbidden gap, which are related to defects localized around selected edges and grain boundaries.

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“…Key words: ChronOS™, β-tricalcium phosphate, reparative osteogenesis. які проводили відповідно до міжнародних стандартів якості ISO 10993-1, демонстрували виключну біосумісність і чудові характеристики сhronOS™ -остеопластичного матеріалу для заміщення кісткових дефектів у травматології, хірургії хребта і стоматології [1,4,6,7,10,11]. Однак, незважаючи на численні роботи, в яких доведено безпеку і біосумісність сhronOS™, інші визначальні властивості остеопластичного матеріалу, такі як динаміка та швидкість його біодеградації, заміщення новоствореною кістковою тканиною в місці імплантації, характеризуються розбіжністю результатів, а саме від 6 до 18 міс.…”

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“…Однак, незважаючи на численні роботи, в яких доведено безпеку і біосумісність сhronOS™, інші визначальні властивості остеопластичного матеріалу, такі як динаміка та швидкість його біодеградації, заміщення новоствореною кістковою тканиною в місці імплантації, характеризуються розбіжністю результатів, а саме від 6 до 18 міс. [4,6,13]. Крім цього, більшість публікацій, присвячених дослідженню сhronOS™ та інших препаратів на основі β-трикальційфосфату, стосуються морфологічних досліджень губчастої кістки, в яких відсутні мікроскопічні характеристики кісткової тканини регенерату [6][7][8]12].…”

unclassified

“…[4,6,13]. Крім цього, більшість публікацій, присвячених дослідженню сhronOS™ та інших препаратів на основі β-трикальційфосфату, стосуються морфологічних досліджень губчастої кістки, в яких відсутні мікроскопічні характеристики кісткової тканини регенерату [6][7][8]12].…”

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Regeneration of long bone after implantation of β-tricalcium phosphate into its defect

Korenkov¹

2015

ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS

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Behaviour of ChronOS™ Inject in metaphyseal bone defects of distal radius fractures: Tissue reaction after 6–15 months

Cited by 8 publications

References 36 publications

The application of autologous platelet-rich plasma gel in cartilage regeneration

The application of autologous platelet-rich plasma gel in cartilage regeneration

Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load‐Bearing and Electroactive Tissues

Regeneration of long bone after implantation of β-tricalcium phosphate into its defect

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