Concrete structures are often in different humidity conditions that have a significant impact on the elastic modulus of concrete, therefore, systematic research on the evolution of the law of concrete elastic modulus under different humidity conditions is needed. In this study, the variation laws of the water saturation of concrete specimens with strength grades C15, C20, and C30 were obtained, and then the influence laws of the water saturation on the concrete axial compressive strength were carried out, and the prediction model of elastic modulus of concrete with respect to water saturation was constructed. The results showed that the water saturation of concrete with strength grades C15, C20, and C30 increased with an extension of immersion time, and the water saturation showed an approximately linear rapid growth within three soaking hours, reaching 47.56%, 71.63%, and 47.29%, respectively. Note, the concrete reached saturation state when the soaking time was 240 h. The axial compressive strength with strength grades C15, C20, and C30 decreased with increased water saturation, and the axial compressive strength of saturated concrete decreased by 27.25%, 21.14%, and 20.76%, respectively, as compared with the dry state concrete. The elastic modulus of concrete with strength grades C15, C20, and C30 increased with increased water saturation, and the elastic modulus of saturated concrete was 1.18, 1.19, and 1.24 times higher than those of dry concrete, respectively.