This paper focuses on the study of the strength of facade sandwich panels used in building construction. The paper describes the results of experimental and numerical research on the behavior of sandwich panels made of polyisocyanurate core (PIR) and their structural connections when exposed to tensile and compressive loads. In the initial phase of this study, laboratory tests were performed to determine the physical and mechanical characteristics of the material from which the sandwich panels are made. Laboratory tensile and compression tests were performed on small samples of sandwich facade panels. In order to verify the obtained results, they were compared with the numerical analysis performed in the ANSYS software. The numerical model was found to accurately predict the results of the laboratory tests, suggesting that the model can be used to predict the behavior of these panels under different loads in service. The study showed that the foam core sandwich panel exhibits excellent mechanical properties. The results indicate the suitability of foam-based composite structures in the construction industry for various applications, such as roof and wall structures. The findings of this study may help in the development of lightweight and durable construction materials for the industry.