Behaviour of polymethoxylated and polyhydroxylated flavones by carbon dioxide supercritical fluid chromatography with flame ionization and fourier transform infrared detectors

Hadj-Mahammed, Mahfoud; Badjah-Hadj-Ahmed, Y.; Meklati, B. Y.

doi:10.1002/pca.2800040606

Cited by 14 publications

(9 citation statements)

References 6 publications

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“…In recent years, a combination of separation and analytical instrumentation has made this technique more powerful and high yielding. In one such study, hydroxyl- and methoxy-flavones were separated employing SFC equipped with flame ionization and FT-IR spectroscopy detection [221]. In another study, a large-scale isolation process was carried out on orange peel extract employing a combination of normal phase column separation and SFC to yield nobiletin, tangeretin, 3,5,6,7,8,3′,4′-hepatamethoxyflavone, and 5,6,7,4′-tetra methoxyflavone [222].…”

Section: Separation Isolation and Purification Of Compounds Postmentioning

confidence: 99%

Modern Extraction and Purification Techniques for Obtaining High Purity Food-Grade Bioactive Compounds and Value-Added Co-Products from Citrus Wastes

Mahato

Sinha

Sharma

et al. 2019

Foods

232

133

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Citrus contains a range of highly beneficial bioactive compounds, such as polyphenols, carotenoids, and vitamins that show antimicrobial and antioxidant properties and help in building the body’s immune system. On consumption or processing, approximately 50% of the fruit remains as inedible waste, which includes peels, seeds, pulp, and segment residues. This waste still consists of substantial quantities of bioactive compounds that cause environmental pollution and are harmful to the ecosystem because of their high biological oxygen demand. In recent years, citrus cultivation and the production of processed foods have become a major agricultural industry. In addition to being a substantial source of economy, it is an ideal and sustainable and renewable resource for obtaining bioactive compounds and co-products for food and pharmaceutical industries. In the present article, the various methods of extraction, conventional and modern, as well as separation and isolation of individual bioactive compounds from the extraction mixture and their determination have been reviewed. This article presents both aspects of extraction methods, i.e., on a small laboratory scale and on an industrial mass scale. These methods and techniques have been extensively and critically reviewed with anticipated future perspectives towards the maximum utilization of the citrus waste.

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Section: Separation Isolation and Purification Of Compounds Postmentioning

confidence: 99%

Modern Extraction and Purification Techniques for Obtaining High Purity Food-Grade Bioactive Compounds and Value-Added Co-Products from Citrus Wastes

Mahato

Sinha

Sharma

et al. 2019

Foods

232

133

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“…Polyketides (PKs) are structurally a very diverse family of natural products with diverse biological activities and pharmacological properties, such as polyketide antibiotics, antifungals, cytostatics, anticholesteremic, antiparasitics and coccidiostats [53]. The analysis of some hydroxy- and methoxy-flavones by cSFC with two types of detectors, FID and Fourier transform infrared (FT-IR) spectroscopy, was presented without the use of modifier in the 1990s [54]. Li et al [55] conducted an investigation into nobiletin's metabolics in mouse urine by various analytical techniques such as RPLC, NPLC and pSFC.…”

Section: Targeted Lipid Profiling By Sfcmentioning

confidence: 99%

Advances of supercritical fluid chromatography in lipid profiling

Yang

Liang

Yang

et al. 2019

Journal of Pharmaceutical Analysis

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Supercritical fluid chromatography (SFC) meets with great favor due to its high efficiency, low organic solvent consumption, and the specialty for the identification of the isomeric species. This review describes the advances of SFC in targeted and untargeted lipid profiling. The advancement of the SFC instruments and the stationary phases are summarized. Typical applications of SFC to the targeted and untargeted lipid profiling are discussed in detail. Moreover, the perspectives of SFC in the lipid profiling are also proposed. As a useful and promising tool for investigating lipids in vitro and in vivo, SFC will predictably obtain further development.

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“…Citrus polymethoxyflavones, a type of plant-occurring flavonoids, have been successfully analyzed by SFC [ 63 ]. These molecules, reported to exert beneficial effects on human cells, such as antiproliferative, anticancer, anti-inflammatory, antilipogenic and antimutagenic, are characterized by the presence of two or more methoxy groups.…”

Section: Applications To Lipid Analysismentioning

confidence: 99%

“…Likewise, SFC separation was achieved using CO 2 /MeOH as mobile phase. Nevertheless, the use of modifier can be avoided, as reported using an oven temperature of 150 °C, and FID and FT-IR detectors [ 63 ].…”

Section: Applications To Lipid Analysismentioning

confidence: 99%

Lipidomics by Supercritical Fluid Chromatography

Laboureur

Ollero

Touboul

2015

IJMS

100

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This review enlightens the role of supercritical fluid chromatography (SFC) in the field of lipid analysis. SFC has been popular in the late 1980s and 1990s before almost disappearing due to the commercial success of liquid chromatography (LC). It is only 20 years later that a regain of interest appeared when new commercial instruments were introduced. As SFC is fully compatible with the injection of extracts in pure organic solvent, this technique is perfectly suitable for lipid analysis and can be coupled with either highly universal (UV or evaporative light scattering) or highly specific (mass spectrometry) detection methods. A short history of the use of supercritical fluids as mobile phase for the separation oflipids will be introduced first. Then, the advantages and drawbacks of SFC are discussed for each class of lipids (fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterols, prenols, polyketides) defined by the LIPID MAPS consortium.

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Behaviour of polymethoxylated and polyhydroxylated flavones by carbon dioxide supercritical fluid chromatography with flame ionization and fourier transform infrared detectors

Cited by 14 publications

References 6 publications

Modern Extraction and Purification Techniques for Obtaining High Purity Food-Grade Bioactive Compounds and Value-Added Co-Products from Citrus Wastes

Modern Extraction and Purification Techniques for Obtaining High Purity Food-Grade Bioactive Compounds and Value-Added Co-Products from Citrus Wastes

Advances of supercritical fluid chromatography in lipid profiling

Lipidomics by Supercritical Fluid Chromatography

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